5A7R

Human poly(ADP-ribose) glycohydrolase in complex with synthetic dimeric ADP-ribose

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
A	0005975	biological_process	carbohydrate metabolic process
A	0006282	biological_process	regulation of DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BME A 1966

Chain	Residue
A	ASP575
A	CYS603
A	PRO673
A	HOH2212

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1967

Chain	Residue
A	HOH2041
A	ILE484
A	ARG485
A	VAL486
A	ASP487
A	PHE498

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1968

Chain	Residue
A	LYS567
A	PRO838
A	ARG842
A	HOH2356
A	HOH2417

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1969

Chain	Residue
A	ALA750
A	AR61965

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1970

Chain	Residue
A	GLU459
A	MET461
A	ARG462
A	ARG466

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1971

Chain	Residue
A	GLU839
A	LYS840
A	ARG843

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1972

Chain	Residue
A	TYR564
A	ARG644
A	ASN646
A	ARG941
A	HOH2127
A	HOH2186

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1973

Chain	Residue
A	TRP506
A	ARG644

---

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 1974

Chain	Residue
A	GLU727
A	GLN735
A	ARG758
A	ASN762
A	GLN788
A	SER809
A	HOH2268
A	HOH2275
A	HOH2314
A	HOH2331

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1975

Chain	Residue
A	GLU709
A	CYS711
A	GLU712
A	THR924
A	ASP927
A	LYS930
A	HOH2418

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1976

Chain	Residue
A	ASN869
A	CYS872
A	ASP904
A	AR61964
A	HOH2378

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 1977

Chain	Residue
A	ALA796
A	GLU797
A	AR61965
A	HOH2325

---

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1978

Chain	Residue
A	HIS828
A	PHE829
A	ARG830
A	ARG831
A	ASP834
A	LYS840
A	HOH2419

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 1979

Chain	Residue
A	ARG685
A	ALA689
A	GLU787

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1980

Chain	Residue
A	ASN508
A	LEU614
A	GLU652
A	HOH2075
A	HOH2200
A	HOH2420

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1981

Chain	Residue
A	ASN740
A	HIS828
A	PHE875
A	AR61965
A	HOH2286
A	HOH2421

---

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 1982

Chain	Residue
A	GLU585
A	LEU589
A	HOH2220

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1983

Chain	Residue
A	HIS501
A	TYR502
A	PRO605
A	ASN606
A	PPI1987
A	HOH2062

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1984

Chain	Residue
A	GLY492
A	GLN551
A	LYS554
A	ALA690
A	HOH2113

---

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PPI A 1985

Chain	Residue
A	HOH2125
A	HOH2195
A	TYR521
A	ARG535
A	TYR560
A	ASN561
A	VAL562

---

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PPI A 1986

Chain	Residue
A	LEU471
A	ARG816
A	HOH2235
A	HOH2313

---

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PPI A 1987

Chain	Residue
A	CYS515
A	GLU517
A	GOL1983
A	HOH2092

---

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PPI A 1988

Chain	Residue
A	GLY724
A	PPI1990
A	HOH2264

---

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PPI A 1989

Chain	Residue
A	SER655
A	ARG741
A	HOH2199

---

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PPI A 1990

Chain	Residue
A	THR725
A	TYR792
A	GLY794
A	PPI1988
A	HOH2318
A	HOH2323

---

site_id	CC8
Number of Residues	35
Details	Binding site for residues AR6 A1964 and AR6 A1965

Chain	Residue
A	ARG663
A	ILE726
A	GLU727
A	PHE738
A	ASN740
A	GLY745
A	SER749
A	ALA750
A	GLY751
A	LEU752
A	VAL753
A	GLN754
A	GLU755
A	ASN756
A	TYR795
A	ASN869
A	GLY871
A	CYS872
A	GLY873
A	ALA874
A	PHE875
A	PHE902
A	SO41969
A	GOL1976
A	GOL1977
A	GOL1981
A	HOH2284
A	HOH2285
A	HOH2288
A	HOH2320
A	HOH2325
A	HOH2326
A	HOH2327
A	HOH2365
A	HOH2416

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	185
Details	Region: {"description":"Catalytic","evidences":[{"source":"PubMed","id":"23251397","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"23251397","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23251397","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23251397","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30472116","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9QYM2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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