5A7R
Human poly(ADP-ribose) glycohydrolase in complex with synthetic dimeric ADP-ribose
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | POLY(ADP-RIBOSE) GLYCOHYDROLASE | polymer | 531 | 60929.2 | 1 | UniProt (Q86W56) Pfam (PF20811) Pfam (PF05028) | HOMO SAPIENS (HUMAN) | |
| 2 | B, C (A) | [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | non-polymer | 559.3 | 2 | Chemie (AR6) | |||
| 3 | D (A) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 1 | Chemie (BME) | |||
| 4 | E, F, G, H, I... (A) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 5 | L, M, N, O, P... (A) | GLYCEROL | non-polymer | 92.1 | 11 | Chemie (GOL) | |||
| 6 | AA, BA, W, X, Y... (A) | PROPANOIC ACID | non-polymer | 74.1 | 6 | Chemie (PPI) | |||
| 7 | CA (A) | water | water | 18.0 | 422 | Chemie (HOH) |
Sequence modifications
A: 448 - 976 (UniProt: Q86W56)
| PDB | External Database | Details |
|---|---|---|
| Gly 446 | - | expression tag |
| Ser 447 | - | expression tag |
| Ala 616 | Lys 616 | engineered mutation |
| Ala 617 | Gln 617 | engineered mutation |
| Ala 618 | Lys 618 | engineered mutation |
| Ala 688 | Glu 688 | engineered mutation |
| Ala 689 | Lys 689 | engineered mutation |
| Ala 690 | Lys 690 | engineered mutation |
| Asn 756 | Glu 756 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 60929.2 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 3326.7 | |
| All* | Total formula weight | 64256.0 |
