Author results

4ACY
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SELENOMETHIONINE DERIVATIVE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTEROIDES THETAIOTAOMICRON
Descriptor:ENDO-ALPHA-MANNOSIDASE, GLYCEROL, FORMIC ACID
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4ACZ
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STRUCTURE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTEROIDES THETAIOTAOMICRON
Descriptor:ENDO-ALPHA-MANNOSIDASE, GLYCEROL
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4AD0
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STRUCTURE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTERIODES THETAIOTAOMICRON IN COMPLEX WITH BIS-TRIS-PROPANE
Descriptor:ENDO-ALPHA-MANNOSIDASE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4AD1
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STRUCTURE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTEROIDES XYLANISOLVENS
Descriptor:GLYCOSYL HYDROLASE FAMILY 71
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4AD2
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STRUCTURE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTEROIDES XYLANISOLVENS IN COMPLEX WITH GLUCOSE-1,3-ISOFAGOMINE
Descriptor:GLYCOSYL HYDROLASE FAMILY 71, alpha-D-glucopyranose, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4AD3
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STRUCTURE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTEROIDES XYLANISOLVENS IN COMPLEX WITH GLUCOSE-1,3-DEOXYMANNOJIRIMYCIN
Descriptor:GLYCOSYL HYDROLASE FAMILY 71, alpha-D-glucopyranose, 1-DEOXYMANNOJIRIMYCIN
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4AD4
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STRUCTURE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTEROIDES XYLANISOLVENS IN COMPLEX WITH GLUCOSE-1,3-ISOFAGOMINE AND ALPHA-1,2- MANNOBIOSE
Descriptor:GLYCOSYL HYDROLASE FAMILY 71, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose, alpha-D-glucopyranose, ...
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4AD5
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STRUCTURE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTEROIDES XYLANISOLVENS IN COMPLEX WITH GLUCOSE-1,3-DEOXYMANNOJIRIMYCIN AND ALPHA-1,2-MANNOBIOSE
Descriptor:GLYCOSYL HYDROLASE FAMILY 71, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose, alpha-D-glucopyranose, ...
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4BM7
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CRYSTAL STRUCTURE OF IGG FC F241A MUTANT WITH NATIVE GLYCOSYLATION
Descriptor:IG GAMMA-1 CHAIN C REGION, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION
Authors:Yu, X., Baruah, K., Harvey, D.J., Vasiljevic, S., Alonzi, D.S., Song, B., Higgins, M.K., Bowden, T.A., Crispin, M., Scanlan, C.N.
Deposit date:2013-05-07
Release date:2013-07-03
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Engineering Hydrophobic Protein-Carbohydrate Interactions to Fine-Tune Monoclonal Antibodies.
J.Am.Chem.Soc., 135, 2013
5F0E
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MURINE ENDOPLASMIC RETICULUM ALPHA-GLUCOSIDASE II
Descriptor:Neutral alpha-glucosidase AB, Glucosidase 2 subunit beta, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Caputo, A.T., Roversi, P., Alonzi, D.S., Kiappes, J.L., Zitzmann, N.
Deposit date:2015-11-27
Release date:2016-07-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structures of mammalian ER alpha-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals.
Proc.Natl.Acad.Sci.USA, 113, 2016
5H9O
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COMPLEX OF MURINE ENDOPLASMIC RETICULUM ALPHA-GLUCOSIDASE II WITH D-GLUCOSE
Descriptor:Neutral alpha-glucosidase AB, Glucosidase 2 subunit beta, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Caputo, A.T., Roversi, P., Alonzi, D.S., Kiappes, J.L., Zitzmann, N.
Deposit date:2015-12-29
Release date:2016-07-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structures of mammalian ER alpha-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals.
Proc.Natl.Acad.Sci.USA, 113, 2016
5HJO
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MURINE ENDOPLASMIC RETICULUM ALPHA-GLUCOSIDASE II WITH BOUND SUBSTRATE ANALOGUE
Descriptor:Neutral alpha-glucosidase AB, Glucosidase 2 subunit beta, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Caputo, A.T., Roversi, P., Alonzi, D.S., Kiappes, J.L., Zitzmann, N.
Deposit date:2016-01-13
Release date:2016-07-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structures of mammalian ER alpha-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals.
Proc.Natl.Acad.Sci.USA, 113, 2016
5HJR
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MURINE ENDOPLASMIC RETICULUM ALPHA-GLUCOSIDASE II WITH BOUND COVALENT INTERMEDIATE
Descriptor:Neutral alpha-glucosidase AB, Glucosidase 2 subunit beta, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Caputo, A.T., Roversi, P., Alonzi, D.S., Kiappes, J.L., Zitzmann, N.
Deposit date:2016-01-13
Release date:2016-07-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of mammalian ER alpha-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals.
Proc.Natl.Acad.Sci.USA, 113, 2016
5IED
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MURINE ENDOPLASMIC RETICULUM ALPHA-GLUCOSIDASE II WITH CASTANOSPERMINE
Descriptor:Neutral alpha-glucosidase AB, Glucosidase 2 subunit beta, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Caputo, A.T., Roversi, P., Alonzi, D.S., Kiappes, J.L., Zitzmann, N.
Deposit date:2016-02-25
Release date:2016-07-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structures of mammalian ER alpha-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals.
Proc.Natl.Acad.Sci.USA, 113, 2016
5IEE
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MURINE ENDOPLASMIC RETICULUM ALPHA-GLUCOSIDASE II WITH 1-DEOXYNOJIRIMYCIN
Descriptor:Neutral alpha-glucosidase AB, Glucosidase 2 subunit beta, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Caputo, A.T., Roversi, P., Alonzi, D.S., Kiappes, J.L., Zitzmann, N.
Deposit date:2016-02-25
Release date:2016-07-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structures of mammalian ER alpha-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals.
Proc.Natl.Acad.Sci.USA, 113, 2016
5IEF
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MURINE ENDOPLASMIC RETICULUM ALPHA-GLUCOSIDASE II WITH N-BUTYL-1-DEOXYNOJIRIMYCIN
Descriptor:Neutral alpha-glucosidase AB, Glucosidase 2 subunit beta, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Caputo, A.T., Roversi, P., Alonzi, D.S., Kiappes, J.L., Zitzmann, N.
Deposit date:2016-02-25
Release date:2016-07-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structures of mammalian ER alpha-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals.
Proc.Natl.Acad.Sci.USA, 113, 2016
5IEG
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MURINE ENDOPLASMIC RETICULUM ALPHA-GLUCOSIDASE II WITH N-9'-METHOXYNONYL-1-DEOXYNOJIRIMYCIN
Descriptor:Neutral alpha-glucosidase AB, Glucosidase 2 subunit beta, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Caputo, A.T., Roversi, P., Alonzi, D.S., Kiappes, J.L., Zitzmann, N.
Deposit date:2016-02-25
Release date:2016-07-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.822 Å)
Cite:Structures of mammalian ER alpha-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals.
Proc.Natl.Acad.Sci.USA, 113, 2016
5MU1
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UDP-GLUCOSE GLYCOPROTEIN GLUCOSYLTRANSFERASE FROM CHAETOMIUM THERMOPHILUM SOAKED WITH K2PTI6
Descriptor:UDP-glucose-glycoprotein glucosyltransferase-like protein, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Roversi, P., Caputo, A.T., Hill, J., Alonzi, D.S., Zitzmann, N.
Deposit date:2017-01-11
Release date:2017-07-26
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.48 Å)
Cite:Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5MZO
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UDP-GLUCOSE GLYCOPROTEIN GLUCOSYLTRANSFERASE FROM CHAETOMIUM THERMOPHILUM (OPEN CONFORMATION)
Descriptor:UDP-glucose-glycoprotein glucosyltransferase-like protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Roversi, P., Caputo, A.T., Hill, J., Alonzi, D.S., Zitzmann, N.
Deposit date:2017-02-01
Release date:2017-07-26
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.48 Å)
Cite:Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5N2J
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UDP-GLUCOSE GLYCOPROTEIN GLUCOSYLTRANSFERASE FROM CHAETOMIUM THERMOPHILUM (CLOSED FORM)
Descriptor:UDP-glucose-glycoprotein glucosyltransferase-like protein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Roversi, P., Caputo, A.T., Hill, J., Alonzi, D.S., Zitzmann, N.
Deposit date:2017-02-07
Release date:2017-07-26
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5NV4
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UDP-GLUCOSE GLYCOPROTEIN GLUCOSYLTRANSFERASE FROM CHAETOMIUM THERMOPHILUM DOUBLE MUTANT D611C:G1050C
Descriptor:UDP-glucose-glycoprotein glucosyltransferase-like protein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Roversi, P., Caputo, A.T., Hill, J., Alonzi, D.S., Zitzmann, N.
Deposit date:2017-05-03
Release date:2017-07-26
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6FSN
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CATALYTIC DOMAIN OF UDP-GLUCOSE GLYCOPROTEIN GLUCOSYLTRANSFERASE FROM CHAETOMIUM THERMOPHILUM IN COMPLEX WITH UDP-GLUCOSE (CONFORMATION 1)
Descriptor:UDP-glucose-glycoprotein glucosyltransferase-like protein, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Roversi, P., Le Cornu, J.D., Hill, J., Alonzi, D.S., Zitzmann, N.
Deposit date:2018-02-19
Release date:2019-03-20
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:The catalytic domain of UGGT, the eukaryotic glycoprotein secretion checkpoint.
To Be Published
6ZDC
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STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN ENDO-ALPHA-MANNOSIDASE MANEA IN COMPLEX WITH NICKEL
Descriptor:Glycoprotein endo-alpha-1,2-mannosidase, NICKEL (II) ION
Authors:Sobala, L.F., Fernandes, P.Z., Hakki, Z., Thompson, A.J., Howe, J.D., Hill, M., Zitzmann, N., Davies, S., Stamataki, Z., Butters, T.D., Alonzi, D.S., Williams, S.J., Davies, G.J.
Deposit date:2020-06-14
Release date:2020-11-18
Last modified:2020-12-02
Method:X-RAY DIFFRACTION (2.251 Å)
Cite:Structure of human endo-alpha-1,2-mannosidase (MANEA), an antiviral host-glycosylation target.
Proc.Natl.Acad.Sci.USA, 117, 2020
6ZDF
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STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN ENDO-ALPHA-MANNOSIDASE MANEA IN COMPLEX WITH HEPES
Descriptor:Glycoprotein endo-alpha-1,2-mannosidase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Sobala, L.F., Fernandes, P.Z., Hakki, Z., Thompson, A.J., Howe, J.D., Hill, M., Zitzmann, N., Davies, S., Stamataki, Z., Butters, T.D., Alonzi, D.S., Williams, S.J., Davies, G.J.
Deposit date:2020-06-14
Release date:2020-11-18
Last modified:2020-12-02
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of human endo-alpha-1,2-mannosidase (MANEA), an antiviral host-glycosylation target.
Proc.Natl.Acad.Sci.USA, 117, 2020
6ZDK
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STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN ENDO-ALPHA-MANNOSIDASE MANEA IN COMPLEX WITH HEPES AND HEXATUNGSTOTELLURATE(VI) TEW
Descriptor:Glycoprotein endo-alpha-1,2-mannosidase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, MAGNESIUM ION, ...
Authors:Sobala, L.F., Fernandes, P.Z., Hakki, Z., Thompson, A.J., Howe, J.D., Hill, M., Zitzmann, N., Davies, S., Stamataki, Z., Butters, T.D., Alonzi, D.S., Williams, S.J., Davies, G.J.
Deposit date:2020-06-14
Release date:2020-11-18
Last modified:2020-12-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of human endo-alpha-1,2-mannosidase (MANEA), an antiviral host-glycosylation target.
Proc.Natl.Acad.Sci.USA, 117, 2020
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171916
PDB entries from 2020-12-02