6ZFA

Structure of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with GlcIFG, alpha-1,2-mannobiose and hexatungstotellurate(VI) TEW

This is a non-PDB format compatible entry.

Summary for 6ZFA

• Entry DOI: 10.2210/pdb6zfa/pdb
• Related PRD ID: PRD_900111
• Descriptor: Glycoprotein endo-alpha-1,2-mannosidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (8 entities in total)
• Functional Keywords: golgi, hydrolase, mannosidase, retaining
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 50559.21

Authors

Sobala, L.F.,Fernandes, P.Z.,Hakki, Z.,Thompson, A.J.,Howe, J.D.,Hill, M.,Zitzmann, N.,Davies, S.,Stamataki, Z.,Butters, T.D.,Alonzi, D.S.,Williams, S.J.,Davies, G.J. (deposition date: 2020-06-16, release date: 2020-11-18, Last modification date: 2024-01-24)

• Primary citation: Sobala, L.F.,Fernandes, P.Z.,Hakki, Z.,Thompson, A.J.,Howe, J.D.,Hill, M.,Zitzmann, N.,Davies, S.,Stamataki, Z.,Butters, T.D.,Alonzi, D.S.,Williams, S.J.,Davies, G.J.; Structure of human endo-alpha-1,2-mannosidase (MANEA), an antiviral host-glycosylation target.; Proc.Natl.Acad.Sci.USA, 117:29595-29601, 2020; PubMed: 33154157; DOI: 10.1073/pnas.2013620117

Experimental method

X-RAY DIFFRACTION (1.8 Å)