5NV4

UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum double mutant D611C:G1050C

Summary for 5NV4

Entry DOI	10.2210/pdb5nv4/pdb
Related	5MU1 5MZ0 5N2J
Descriptor	UDP-glucose-glycoprotein glucosyltransferase-like protein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	glycoprotein, misfolding, transferase, endoplasmic reticulum
Biological source	Chaetomium thermophilum var. thermophilum DSM 1495
Total number of polymer chains	1
Total formula weight	171189.88
Authors	Roversi, P.,Caputo, A.T.,Hill, J.,Alonzi, D.S.,Zitzmann, N. (deposition date: 2017-05-03, release date: 2017-07-26, Last modification date: 2024-01-17)
Primary citation	Roversi, P.,Marti, L.,Caputo, A.T.,Alonzi, D.S.,Hill, J.C.,Dent, K.C.,Kumar, A.,Levasseur, M.D.,Lia, A.,Waksman, T.,Basu, S.,Soto Albrecht, Y.,Qian, K.,McIvor, J.P.,Lipp, C.B.,Siliqi, D.,Vasiljevic, S.,Mohammed, S.,Lukacik, P.,Walsh, M.A.,Santino, A.,Zitzmann, N. Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint. Proc. Natl. Acad. Sci. U.S.A., 114:8544-8549, 2017 Cited by PubMed: 28739903 DOI: 10.1073/pnas.1703682114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.78 Å)

Structure validation