6ZDF

Structure of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with HEPES

Summary for 6ZDF

Entry DOI	10.2210/pdb6zdf/pdb
Descriptor	Glycoprotein endo-alpha-1,2-mannosidase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID (3 entities in total)
Functional Keywords	golgi, hydrolase, mannosidase, retaining
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	135064.20
Authors	Sobala, L.F.,Fernandes, P.Z.,Hakki, Z.,Thompson, A.J.,Howe, J.D.,Hill, M.,Zitzmann, N.,Davies, S.,Stamataki, Z.,Butters, T.D.,Alonzi, D.S.,Williams, S.J.,Davies, G.J. (deposition date: 2020-06-14, release date: 2020-11-18, Last modification date: 2024-01-24)
Primary citation	Sobala, L.F.,Fernandes, P.Z.,Hakki, Z.,Thompson, A.J.,Howe, J.D.,Hill, M.,Zitzmann, N.,Davies, S.,Stamataki, Z.,Butters, T.D.,Alonzi, D.S.,Williams, S.J.,Davies, G.J. Structure of human endo-alpha-1,2-mannosidase (MANEA), an antiviral host-glycosylation target. Proc.Natl.Acad.Sci.USA, 117:29595-29601, 2020 Cited by PubMed: 33154157 DOI: 10.1073/pnas.2013620117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation