6ZFQ

Structure of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with bis-tris

This is a non-PDB format compatible entry.

Summary for 6ZFQ

DescriptorGlycoprotein endo-alpha-1,2-mannosidase, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL (3 entities in total)
Functional Keywordsgolgi, hydrolase, mannosidase, retaining
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight44992.33
Authors
Primary citation
Sobala, L.F.,Fernandes, P.Z.,Hakki, Z.,Thompson, A.J.,Howe, J.D.,Hill, M.,Zitzmann, N.,Davies, S.,Stamataki, Z.,Butters, T.D.,Alonzi, D.S.,Williams, S.J.,Davies, G.J.
Structure of human endo-alpha-1,2-mannosidase (MANEA), an antiviral host-glycosylation target.
Proc.Natl.Acad.Sci.USA, 2020
PubMed: 33154157 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.2013620117
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.1912 0.3% 1.3% 3.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171588
PDB entries from 2020-11-25