Structure of an inactive E404Q variant of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with 1-methyl alpha-1,2-mannobiose

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Summary for 6ZFN

DescriptorGlycoprotein endo-alpha-1,2-mannosidase, alpha-D-mannopyranose-(1-2)-methyl alpha-D-mannopyranoside, SULFATE ION, ... (4 entities in total)
Functional Keywordsgolgi, hydrolase, mannosidase, retaining
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight45234.5
Primary citation
Sobala, L.F.,Fernandes, P.Z.,Hakki, Z.,Thompson, A.J.,Howe, J.D.,Hill, M.,Zitzmann, N.,Davies, S.,Stamataki, Z.,Butters, T.D.,Alonzi, D.S.,Williams, S.J.,Davies, G.J.
Structure of human endo-alpha-1,2-mannosidase (MANEA), an antiviral host-glycosylation target.
Proc.Natl.Acad.Sci.USA, 2020
PubMed: 33154157 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.2013620117
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.12920 0.3% 4.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-11-25