Author results

2UXN
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STRUCTURAL BASIS OF HISTONE DEMETHYLATION BY LSD1 REVEALED BY SUICIDE INACTIVATION
Descriptor:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, HISTONE H3.1, ...
Authors:Yang, M., Culhane, J.C., Szewczuk, L.M., Gocke, C.B., Brautigam, C.A., Tomchick, D.R., Machius, M., Cole, P.A., Yu, H.
Deposit date:2007-03-28
Release date:2007-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Structural Basis of Histone Demethylation by Lsd1 Revealed by Suicide Inactivation.
Nat.Struct.Mol.Biol., 14, 2007
2UXX
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HUMAN LSD1 HISTONE DEMETHYLASE-COREST IN COMPLEX WITH AN FAD- TRANYLCYPROMINE ADDUCT
Descriptor:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FAD-trans-2-Phenylcyclopropylamine Adduct, ...
Authors:Yang, M., Culhane, J.C., Machius, M., Cole, P.A., Yu, H.
Deposit date:2007-03-30
Release date:2007-08-21
Last modified:2013-03-27
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Structural Basis for the Inhibition of the Lsd1 Histone Demethylase by the Antidepressant Trans-2-Phenylcyclopropylamine.
Biochemistry, 46, 2007
2IW5
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STRUCTURAL BASIS FOR COREST-DEPENDENT DEMETHYLATION OF NUCLEOSOMES BY THE HUMAN LSD1 HISTONE DEMETHYLASE
Descriptor:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Yang, M., Gocke, C.B., Luo, X., Borek, D., Tomchick, D.R., Machius, M., Otwinowski, Z., Yu, H.
Deposit date:2006-06-26
Release date:2006-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Structural Basis for Corest-Dependent Demethylation of Nucleosomes by the Human Lsd1 Histone Demethylase
Mol.Cell, 23, 2006
2VFX
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STRUCTURE OF THE SYMMETRIC MAD2 DIMER
Descriptor:MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Yang, M., Li, B., Liu, C.-J., Tomchick, D.R., Machius, M., Rizo, J., Yu, H., Luo, X.
Deposit date:2007-11-05
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Insights Into MAD2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric MAD2 Dimer.
Plos Biol., 6, 2008
2H2N
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CRYSTAL STRUCTURE OF HUMAN SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE (SCAN) WITH CALCIUM ION
Descriptor:Soluble calcium-activated nucleotidase 1, CALCIUM ION, ACETATE ION
Authors:Yang, M., Horii, K., Herr, A.B., Kirley, T.L.
Deposit date:2006-05-19
Release date:2006-07-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Calcium-dependent dimerization of human soluble calcium activated nucleotidase: characterization of the dimer interface.
J.Biol.Chem., 281, 2006
2H2U
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CRYSTAL STRUCTURE OF THE E130Y MUTANT OF HUMAN SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE (SCAN) WITH CALCIUM ION
Descriptor:Soluble calcium-activated nucleotidase 1, CALCIUM ION
Authors:Yang, M., Horii, K., Herr, A.B., Kirley, T.L.
Deposit date:2006-05-19
Release date:2006-07-18
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Calcium-dependent dimerization of human soluble calcium activated nucleotidase: characterization of the dimer interface.
J.Biol.Chem., 281, 2006
4HY6
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CRYSTAL STRUCTURE OF THE HUMAN HSP90-ALPHA N-DOMAIN BOUND TO THE HSP90 INHIBITOR FJ1
Descriptor:Heat shock protein HSP 90-alpha, 6,6-dimethyl-3-(trifluoromethyl)-1,5,6,7-tetrahydro-4H-indazol-4-one
Authors:Yang, M., Li, J., He, J.H.
Deposit date:2012-11-13
Release date:2013-05-15
Method:X-RAY DIFFRACTION (1.649 Å)
Cite:Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1
to be published
4IKG
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CRYSTAL STRUCTURE OF CELL DEATH-INDUCING DFFA-LIKE EFFECTOR C
Descriptor:Cell death activator CIDE-3, IODIDE ION
Authors:Yang, M., Gao, J.
Deposit date:2012-12-26
Release date:2014-06-04
Method:X-RAY DIFFRACTION (1.9318 Å)
Cite:Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes.
Nat Commun, 4, 2013
5I5N
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CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF MATRIX PROTEIN OF THOGOTO VIRUS AT ACIDIC PH.
Descriptor:Matrix protein
Authors:Liu, Y., Liang, H., Yang, M.
Deposit date:2016-02-15
Release date:2016-08-17
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.418 Å)
Cite:pH-dependent conformational changes of a Thogoto virus matrix protein reveal mechanisms of viral assembly and uncoating
J.Gen.Virol., 97, 2016
5I5O
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CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF MATRIX PROTEIN OF THOGOTO VIRUS AT NEUTRAL PH.
Descriptor:Matrix protein
Authors:Liu, Y., Liang, H., Yang, M.
Deposit date:2016-02-15
Release date:2016-08-17
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.682 Å)
Cite:pH-dependent conformational changes of a Thogoto virus matrix protein reveal mechanisms of viral assembly and uncoating
J.Gen.Virol., 97, 2016
4NQJ
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STRUCTURE OF COILED-COIL DOMAIN
Descriptor:E3 ubiquitin-protein ligase TRIM69, DODECYL-BETA-D-MALTOSIDE
Authors:Yang, M., Li, Y.
Deposit date:2013-11-25
Release date:2014-05-21
Method:X-RAY DIFFRACTION (2.152 Å)
Cite:Structural insights into the TRIM family of ubiquitin E3 ligases
Cell Res., 2014
4W78
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CRYSTAL STRUCTURE OF THE CHSH1-CHSH2 COMPLEX FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Hydratase ChsH1, Hydratase ChsH2, CADMIUM ION, ...
Authors:Guja, K.E., Yang, M., Sampson, N., Garcia-Diaz, M.
Deposit date:2014-08-21
Release date:2014-10-08
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.541 Å)
Cite:A Distinct MaoC-like Enoyl-CoA Hydratase Architecture Mediates Cholesterol Catabolism in Mycobacterium tuberculosis.
Acs Chem.Biol., 9, 2014
4WNB
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CRYSTAL STRUCTURE OF THE CHSH1-CHSH2 COMPLEX FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO 3-OPC-COA
Descriptor:Hydratase ChsH2, Hydratase ChsH1, CADMIUM ION, ...
Authors:Guja, K.E., Yang, M., Sampson, N., Garcia-Diaz, M.
Deposit date:2014-10-11
Release date:2014-10-29
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:A Distinct MaoC-like Enoyl-CoA Hydratase Architecture Mediates Cholesterol Catabolism in Mycobacterium tuberculosis.
Acs Chem.Biol., 9, 2014
4X28
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CRYSTAL STRUCTURE OF THE CHSE4-CHSE5 COMPLEX FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Acyl-CoA dehydrogenase, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE
Authors:Guja, K.E., Yang, M., Sampson, N., Garcia-Diaz, M.
Deposit date:2014-11-26
Release date:2015-02-18
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Unraveling Cholesterol Catabolism in Mycobacterium tuberculosis: ChsE4-ChsE5 alpha 2 beta 2 Acyl-CoA Dehydrogenase Initiates beta-Oxidation of 3-Oxo-cholest-4-en-26-oyl CoA.
Acs Infect Dis., 1, 2015
3T9N
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CRYSTAL STRUCTURE OF A MEMBRANE PROTEIN
Descriptor:Small-conductance mechanosensitive channel, DODECYL-BETA-D-MALTOSIDE
Authors:Yang, M., Zhang, X., Ge, J., Wang, J.
Deposit date:2011-08-03
Release date:2012-10-31
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (3.456 Å)
Cite:Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance
Proc.Natl.Acad.Sci.USA, 109, 2012
4PSW
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CRYSTAL STRUCTURE OF HISTONE ACETYLTRANSFERASE COMPLEX
Descriptor:Histone acetyltransferase type B catalytic subunit, Histone acetyltransferase type B subunit 2, Histone H4 type VIII, ...
Authors:Yang, M., Li, Y.
Deposit date:2014-03-08
Release date:2014-07-09
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Hat2p recognizes the histone H3 tail to specify the acetylation of the newly synthesized H3/H4 heterodimer by the Hat1p/Hat2p complex
Genes Dev., 28, 2014
4PSX
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CRYSTAL STRUCTURE OF HISTONE ACETYLTRANSFERASE COMPLEX
Descriptor:Histone acetyltransferase type B catalytic subunit, Histone acetyltransferase type B subunit 2, Histone H4, ...
Authors:Yang, M., Li, Y.
Deposit date:2014-03-08
Release date:2014-07-09
Method:X-RAY DIFFRACTION (2.509 Å)
Cite:Hat2p recognizes the histone H3 tail to specify the acetylation of the newly synthesized H3/H4 heterodimer by the Hat1p/Hat2p complex
Genes Dev., 28, 2014
5WY5
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CRYSTAL STRUCTURE OF MAGEG1 AND NSE1 COMPLEX
Descriptor:Melanoma-associated antigen G1, Non-structural maintenance of chromosomes element 1 homolog, MAGNESIUM ION, ...
Authors:Yang, M., Gao, J.
Deposit date:2017-01-11
Release date:2017-05-03
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Mage-Ring Protein Complexes Comprise A Family Of E3 Ubiquitin Ligases.
Mol.Cell, 39, 2010
5YDZ
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STRUCTURE OF ENDO-LYSOSOMAL TRPML1 CHANNEL INSERTING INTO AMPHIPOL: STATE 1
Descriptor:mammalian endo-lysosomal TRPML1 channel
Authors:Yang, M., Gao, N.
Deposit date:2017-09-15
Release date:2017-12-27
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8, 2017
5YE1
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STRUCTURE OF ENDO-LYSOSOMAL TRPML1 CHANNEL INSERTING INTO AMPHIPOL: STATE 2
Descriptor:Mucolipin-1
Authors:Yang, M., Gao, N.
Deposit date:2017-09-15
Release date:2017-12-27
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8, 2017
5YE2
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MAMMALIAN ENDO-LYSOSOMAL TRPML1 CHANNEL INSERTING INTO AMPHIPOL
Descriptor:mammalian endo-lysosomal TRPML1 channel
Authors:Yang, M., Gao, N.
Deposit date:2017-09-15
Release date:2017-12-27
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8, 2017
5YE5
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STRUCTURE OF ENDO-LYSOSOMAL TRPML1 CHANNEL INSERTING INTO NANODISC
Descriptor:mammalian endo-lysosomal TRPML1 channel, N-ACETYL-D-GLUCOSAMINE
Authors:Yang, M., Gao, N.
Deposit date:2017-09-15
Release date:2017-11-15
Last modified:2017-11-22
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8, 2017
1UJ1
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CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (3CLPRO)
Descriptor:3C-like proteinase
Authors:Yang, H., Yang, M., Liu, Y., Bartlam, M., Ding, Y., Lou, Z., Sun, L., Zhou, Z., Ye, S., Anand, K., Pang, H., Gao, G.F., Hilgenfeld, R., Rao, Z.
Deposit date:2003-07-25
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100, 2003
1UK2
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CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (3CLPRO) AT PH8.0
Descriptor:3C-LIKE PROTEINASE
Authors:Yang, H., Yang, M., Liu, Y., Bartlam, M., Ding, Y., Lou, Z., Sun, L., Zhou, Z., Ye, S., Anand, K., Pang, H., Gao, G.F., Hilgenfeld, R., Rao, Z.
Deposit date:2003-08-14
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100, 2003
1UK3
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CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (3CLPRO) AT PH7.6
Descriptor:3C-like proteinase
Authors:Yang, H., Yang, M., Liu, Y., Bartlam, M., Ding, Y., Lou, Z., Sun, L., Zhou, Z., Ye, S., Anand, K., Pang, H., Gao, G.F., Hilgenfeld, R., Rao, Z.
Deposit date:2003-08-14
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100, 2003
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