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4HY6

Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1

Summary for 4HY6
Entry DOI10.2210/pdb4hy6/pdb
DescriptorHeat shock protein HSP 90-alpha, 6,6-dimethyl-3-(trifluoromethyl)-1,5,6,7-tetrahydro-4H-indazol-4-one (3 entities in total)
Functional Keywordsatp binding, molecularchaperone, inhibitor, rossmann fold, molecular chaperone, atp hydrolysis, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P07900
Total number of polymer chains1
Total formula weight25888.97
Authors
Yang, M.,Li, J.,He, J.H. (deposition date: 2012-11-13, release date: 2013-05-15, Last modification date: 2023-11-08)
Primary citationYang, M.,Li, J.,He, J.H.
Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1
to be published,
Experimental method
X-RAY DIFFRACTION (1.649 Å)
Structure validation

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