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2C9T
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CRYSTAL STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) FROM APLYSIA CALIFORNICA IN COMPLEX WITH ALPHA-CONOTOXIN IMI
Descriptor:SOLUBLE ACETYLCHOLINE RECEPTOR, ALPHA-CONOTOXIN IMI
Authors:Ulens, C., Hogg, R.C., Celie, P.H., Bertrand, D., Tsetlin, V., Smit, A.B., Sixma, T.K.
Deposit date:2005-12-14
Release date:2006-02-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural Determinants of Selective {Alpha}-Conotoxin Binding to a Nicotinic Acetylcholine Receptor Homolog Achbp.
Proc.Natl.Acad.Sci.USA, 103, 2006
2W8F
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APLYSIA CALIFORNICA ACHBP BOUND TO IN SILICO COMPOUND 31
Descriptor:SOLUBLE ACETYLCHOLINE RECEPTOR, (3-EXO)-3-(10,11-DIHYDRO-5H-DIBENZO[A,D][7]ANNULEN-5-YLOXY)-8,8-DIMETHYL-8-AZONIABICYCLO[3.2.1]OCTANE
Authors:Ulens, C., Akdemir, A., Jongejan, A., van Elk, R., Edink, E., Bertrand, S., Perrakis, A., Leurs, R., Smit, A.B., Sixma, T.K., Bertrand, D., de Esch, I.J.
Deposit date:2009-01-16
Release date:2009-04-14
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Use of Acetylcholine Binding Protein in the Search for Novel Alpha7 Nicotinic Receptor Ligands. In Silico Docking, Pharmacological Screening, and X- Ray Analysis.
J.Med.Chem., 52, 2009
2W8G
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APLYSIA CALIFORNICA ACHBP BOUND TO IN SILICO COMPOUND 35
Descriptor:SOLUBLE ACETYLCHOLINE RECEPTOR, (3-ENDO,8-ANTI)-8-BENZYL-3-(10,11-DIHYDRO-5H-DIBENZO[A,D][7]ANNULEN-5-YLOXY)-8-AZONIABICYCLO[3.2.1]OCTANE
Authors:Ulens, C., Akdemir, A., Jongejan, A., van Elk, R., Edink, E., Bertrand, S., Perrakis, A., Leurs, R., Smit, A.B., Sixma, T.K., Bertrand, D., de Esch, I.J.
Deposit date:2009-01-16
Release date:2009-04-14
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Use of Acetylcholine Binding Protein in the Search for Novel Alpha7 Nicotinic Receptor Ligands. In Silico Docking, Pharmacological Screening, and X- Ray Analysis.
J.Med.Chem., 52, 2009
2Y7Y
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APLYSIA CALIFORNICA ACHBP IN APO STATE
Descriptor:SOLUBLE ACETYLCHOLINE RECEPTOR
Authors:Ulens, C., Akdemir, A., Jongejan, A., van Elk, R., Bertrand, S., Perrakis, A., Leurs, R., Smit, A.B., Sixma, T.K., Bertrand, D., De Esch, I.J.
Deposit date:2011-02-02
Release date:2011-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.895 Å)
Cite:Use of Acetylcholine Binding Protein in the Search for Novel Alpha7 Nicotinic Receptor Ligands. In Silico Docking, Pharmacological Screening, and X-Ray Analysis.
J.Med.Chem., 52, 2009
4TWD
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X-RAY STRUCTURE OF A PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI (ELIC) IN COMPLEX WITH MEMANTINE
Descriptor:Cys-loop ligand-gated ion channel, Memantine
Authors:Ulens, C., Spurny, R., Thompson, A.J., Alqazzaz, M., Debaveye, S., Lu, H., Price, K., Villalgordo, J.M., Tresadern, G., Lynch, J.W., Lummis, S.C.R.
Deposit date:2014-06-30
Release date:2014-09-24
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The Prokaryote Ligand-Gated Ion Channel ELIC Captured in a Pore Blocker-Bound Conformation by the Alzheimer's Disease Drug Memantine.
Structure, 22, 2014
4TWF
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X-RAY STRUCTURE OF A PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI (ELIC) IN COMPLEX WITH BROMOMEMANTINE
Descriptor:Cys-loop ligand-gated ion channel, Bromomemantine
Authors:Ulens, C., Spurny, R., Thompson, A.J., Alqazzaz, M., Debaveye, S., Lu, H., Price, K., Villalgordo, J.M., Tresadern, G., Lynch, J.W., Lummis, S.C.R.
Deposit date:2014-06-30
Release date:2014-09-24
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (3.901 Å)
Cite:The Prokaryote Ligand-Gated Ion Channel ELIC Captured in a Pore Blocker-Bound Conformation by the Alzheimer's Disease Drug Memantine.
Structure, 22, 2014
4TWH
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X-RAY STRUCTURE OF A PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI (ELIC) MUTANT F16'S
Descriptor:Cys-loop ligand-gated ion channel
Authors:Ulens, C., Spurny, R., Thompson, A.J., Alqazzaz, M., Debaveye, S., Lu, H., Price, K., Villalgordo, J.M., Tresadern, G., Lynch, J.W., Lummis, S.C.R.
Deposit date:2014-06-30
Release date:2014-09-24
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The Prokaryote Ligand-Gated Ion Channel ELIC Captured in a Pore Blocker-Bound Conformation by the Alzheimer's Disease Drug Memantine.
Structure, 22, 2014
2UZ6
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ACHBP-TARGETED A-CONOTOXIN CORRELATES DISTINCT BINDING ORIENTATIONS WITH NACHR SUBTYPE SELECTIVITY.
Descriptor:SOLUBLE ACETYLCHOLINE RECEPTOR, ALPHA-CONOTOXIN TXIA(A10L), N-ACETYL-D-GLUCOSAMINE, ...
Authors:Ulens, C., Dutertre, S., Buttner, R., Fish, A., van Elk, R., Kendel, Y., Hopping, G., Alewood, P.F., Schroeder, C., Nicke, A., Smit, A.B., Sixma, T.K., Lewis, R.J.
Deposit date:2007-04-25
Release date:2007-08-07
Last modified:2013-01-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Achbp-Targeted Alpha-Conotoxin Correlates Distinct Binding Orientations with Nachr Subtype Selectivity
Embo J., 26, 2007
6SSI
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STRUCTURE OF THE PENTAMERIC LIGAND-GATED ION CHANNEL ELIC IN COMPLEX WITH A PAM NANOBODY
Descriptor:Cys-loop ligand-gated ion channel, NANOBODY 22, GAMMA-AMINO-BUTANOIC ACID, ...
Authors:Ulens, C., Brams, M., Evans, G.L., Spurny, R., Govaerts, C., Pardon, E., Steyaert, J.
Deposit date:2019-09-07
Release date:2020-02-12
Last modified:2020-02-19
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Modulation of theErwinialigand-gated ion channel (ELIC) and the 5-HT3receptor via a common vestibule site.
Elife, 9, 2020
6SSP
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STRUCTURE OF THE PENTAMERIC LIGAND-GATED ION CHANNEL ELIC IN COMPLEX WITH A NAM NANOBODY
Descriptor:Cys-loop ligand-gated ion channel, NANOBODY 21, CALCIUM ION, ...
Authors:Ulens, C., Brams, M., Evans, G.L., Spurny, R., Govaerts, C., Pardon, E., Steyaert, J.
Deposit date:2019-09-09
Release date:2020-02-12
Last modified:2020-02-19
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Modulation of theErwinialigand-gated ion channel (ELIC) and the 5-HT3receptor via a common vestibule site.
Elife, 9, 2020
5LXB
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CRYSTAL STRUCTURE OF A MUTANT BINDING PROTEIN (5HTBP-ACHBP) IN COMPLEX WITH PALONOSETRON
Descriptor:Soluble acetylcholine receptor, N-ACETYL-D-GLUCOSAMINE, palonosetron
Authors:Ulens, C.
Deposit date:2016-09-20
Release date:2016-10-12
Last modified:2017-01-11
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Palonosetron-5-HT3 Receptor Interactions As Shown by a Binding Protein Cocrystal Structure.
ACS Chem Neurosci, 7, 2016
4B56
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STRUCTURE OF ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE-1 (NPP1)
Descriptor:ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 1, ZINC ION, CALCIUM ION, ...
Authors:Jansen, S., Perrakis, A., Ulens, C., Winkler, C., Andries, M., Joosten, R.P., Van Acker, M., Luyten, F.P., Moolenaar, W.H., Bollen, M.
Deposit date:2012-08-02
Release date:2012-09-19
Last modified:2012-11-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of Npp1, an Ectonucleotide Pyrophosphatase/Phosphodiesterase Involved in Tissue Calcification.
Structure, 20, 2012
6HJX
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X-RAY STRUCTURE OF A PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI (ELIC) 7'C PORE MUTANT (L238C) IN COMPLEX WITH NANOBODY 72
Descriptor:Cys-loop ligand-gated ion channel, nanobody 72, HEXAETHYLENE GLYCOL, ...
Authors:Spurny, R., Govaerts, C., Evans, G.L., Pardon, E., Steyaert, J., Ulens, C.
Deposit date:2018-09-04
Release date:2019-10-09
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A lipid site shapes the agonist response of a pentameric ligand-gated ion channel.
Nat.Chem.Biol., 15, 2019
6HJY
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X-RAY STRUCTURE OF A PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI (ELIC) DELTA8 TRUNCATION MUTANT IN COMPLEX WITH NANOBODY 72
Descriptor:Cys-loop ligand-gated ion channel, nanobody 72
Authors:Spurny, R., Govaerts, C., Evans, G.L., Pardon, E., Steyaert, J., Ulens, C.
Deposit date:2018-09-04
Release date:2019-10-09
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:A lipid site shapes the agonist response of a pentameric ligand-gated ion channel.
Nat.Chem.Biol., 15, 2019
6HK0
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X-RAY STRUCTURE OF A PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI (ELIC) F16'S PORE MUTANT (F247S) WITH ALTERNATE M4 CONFORMATION.
Descriptor:Cys-loop ligand-gated ion channel, DODECYL-BETA-D-MALTOSIDE
Authors:Nury, H., Spurny, R., Govaerts, C., Evans, G.L., Pardon, E., Steyaert, J., Ulens, C.
Deposit date:2018-09-04
Release date:2019-10-09
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:A lipid site shapes the agonist response of a pentameric ligand-gated ion channel.
Nat.Chem.Biol., 15, 2019
2XYS
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CRYSTAL STRUCTURE OF APLYSIA CALIFORNICA ACHBP IN COMPLEX WITH STRYCHNINE
Descriptor:SOLUBLE ACETYLCHOLINE RECEPTOR, STRYCHNINE
Authors:Brams, M., Pandya, A., Kuzmin, D., van Elk, R., Krijnen, L., Yakel, J.L., Tsetlin, V., Smit, A.B., Ulens, C.
Deposit date:2010-11-19
Release date:2011-03-23
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (1.909 Å)
Cite:A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and D-Tubocurarine by Different Cys-Loop Receptors.
Plos Biol., 9, 2011
2XYT
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CRYSTAL STRUCTURE OF APLYSIA CALIFORNICA ACHBP IN COMPLEX WITH D- TUBOCURARINE
Descriptor:SOLUBLE ACETYLCHOLINE RECEPTOR, D-TUBOCURARINE
Authors:Brams, M., Pandya, A., Kuzmin, D., van Elk, R., Krijnen, L., Yakel, J.L., Tsetlin, V., Smit, A.B., Ulens, C.
Deposit date:2010-11-19
Release date:2011-03-23
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and D-Tubocurarine by Different Cys-Loop Receptors.
Plos Biol., 9, 2011
2XZ5
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MMTS-MODIFIED Y53C MUTANT OF APLYSIA ACHBP IN COMPLEX WITH ACETYLCHOLINE
Descriptor:SOLUBLE ACETYLCHOLINE RECEPTOR, ACETYLCHOLINE, CHLORIDE ION, ...
Authors:Brams, M., Gay, E.A., Colon Saez, J., Guskov, A., van Elk, R., van der Schors, R.C., Peigneur, S., Tytgat, J., Strelkov, S.V., Smit, A.B., Yakel, J.L., Ulens, C.
Deposit date:2010-11-23
Release date:2010-12-08
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structures of a Cysteine-Modified Mutant in Loop D of Acetylcholine Binding Protein
J.Biol.Chem., 286, 2011
2XZ6
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MTSET-MODIFIED Y53C MUTANT OF APLYSIA ACHBP
Descriptor:SOLUBLE ACETYLCHOLINE RECEPTOR, 2-(TRIMETHYLAMMONIUM)ETHYL THIOL
Authors:Brams, M., Gay, E.A., Colon Saez, J., Guskov, A., Van Elk, R., Van Der Schors, R.C., Peigneur, S., Tytgat, J., Strelkov, S.V., Smit, A.B., Yakel, J.L., Ulens, C.
Deposit date:2010-11-23
Release date:2010-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.137 Å)
Cite:Crystal Structures of a Cysteine-Modified Mutant in Loop D of Acetylcholine Binding Protein
J.Biol.Chem., 286, 2011
2YMD
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CRYSTAL STRUCTURE OF A MUTANT BINDING PROTEIN (5HTBP-ACHBP) IN COMPLEX WITH SEROTONIN (5-HYDROXYTRYPTAMINE)
Descriptor:SOLUBLE ACETYLCHOLINE RECEPTOR, SEROTONIN, GLYCEROL, ...
Authors:Kesters, D., Thompson, A.J., Brams, M., Elk, R.v., Spurny, R., Geitmann, M., Villalgordo, J.M., Guskov, A., Danielson, U.H., Lummis, S.C.R., Smit, A.B., Ulens, C.
Deposit date:2012-10-09
Release date:2012-12-12
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structural Basis of Ligand Recognition in 5-Ht(3) Receptors.
Embo Rep., 14, 2013
2YME
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CRYSTAL STRUCTURE OF A MUTANT BINDING PROTEIN (5HTBP-ACHBP) IN COMPLEX WITH GRANISETRON
Descriptor:SOLUBLE ACETYLCHOLINE RECEPTOR, N-ACETYL-D-GLUCOSAMINE, 1-methyl-N-[(1R,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide, ...
Authors:Kesters, D., Thompson, A.J., Brams, M., Elk, R.v., Spurny, R., Geitmann, M., Villalgordo, J.M., Guskov, A., Danielson, U.H., Lummis, S.C.R., Smit, A.B., Ulens, C.
Deposit date:2012-10-09
Release date:2012-12-26
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis of Ligand Recognition in 5-Ht3 Receptors.
Embo Rep., 14, 2013
2YOE
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X-RAY STRUCTURE OF A PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI (ELIC) IN COMPLEX WITH GABA AND FLURAZEPAM
Descriptor:CYS-LOOP LIGAND-GATED ION CHANNEL, GAMMA-AMINO-BUTANOIC ACID, Flurazepam
Authors:Spurny, R., Brams, M., Nury, H., Legrand, P., Ulens, C.
Deposit date:2012-10-23
Release date:2012-10-31
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Pentameric Ligand-Gated Ion Channel Elic is Activated by Gaba and Modulated by Benzodiazepines.
Proc.Natl.Acad.Sci.USA, 109, 2012
3ZKR
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X-RAY STRUCTURE OF A PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI (ELIC) IN COMPLEX WITH BROMOFORM
Descriptor:CYS-LOOP LIGAND-GATED ION CHANNEL, TRIBROMOMETHANE
Authors:Spurny, R., Billen, B., Howard, R.J., Brams, M., Debaveye, S., Price, K.L., Weston, D.A., Strelkov, S.V., Tytgat, J., Bertrand, S., Bertrand, D., Lummis, S.C.R., Ulens, C.
Deposit date:2013-01-24
Release date:2013-02-06
Last modified:2014-09-17
Method:X-RAY DIFFRACTION (3.649 Å)
Cite:Multisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia Chrysanthemi Ligand-Gated Ion Channel (Elic).
J.Biol.Chem., 288, 2013
4A97
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X-RAY STRUCTURE OF A PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI (ELIC) IN COMPLEX WITH ZOPICLONE
Descriptor:CYS-LOOP LIGAND-GATED ION CHANNEL, (5R)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate
Authors:Spurny, R., Brams, M., Ulens, C.
Deposit date:2011-11-24
Release date:2012-10-17
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (3.343 Å)
Cite:Pentameric Ligand-Gated Ion Channel Elic is Activated by Gaba and Modulated by Benzodiazepines.
Proc.Natl.Acad.Sci.USA, 109, 2012
4A98
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X-RAY STRUCTURE OF A PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI (ELIC) IN COMPLEX WITH BROMOFLURAZEPAM
Descriptor:CYS-LOOP LIGAND-GATED ION CHANNEL, 7-BROMO-1-[2-(DIETHYLAMINO)ETHYL]-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE
Authors:Spurny, R., Brams, M., Nury, H., Legrand, P., Ulens, C.
Deposit date:2011-11-24
Release date:2012-10-17
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (3.61 Å)
Cite:Pentameric Ligand-Gated Ion Channel Elic is Activated by Gaba and Modulated by Benzodiazepines.
Proc.Natl.Acad.Sci.USA, 109, 2012
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