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4TWD

X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with memantine

Summary for 4TWD
Entry DOI10.2210/pdb4twd/pdb
DescriptorCys-loop ligand-gated ion channel, Memantine (2 entities in total)
Functional Keywordselic, lgic, cys-loop, channel, memantine, pore blocker, transport protein
Biological sourceDickeya chrysanthemi (Pectobacterium chrysanthemi)
Cellular locationCell inner membrane ; Multi- pass membrane protein : P0C7B7
Total number of polymer chains10
Total formula weight354963.53
Authors
Ulens, C.,Spurny, R.,Thompson, A.J.,Alqazzaz, M.,Debaveye, S.,Lu, H.,Price, K.,Villalgordo, J.M.,Tresadern, G.,Lynch, J.W.,Lummis, S.C.R. (deposition date: 2014-06-30, release date: 2014-09-24, Last modification date: 2023-12-20)
Primary citationUlens, C.,Spurny, R.,Thompson, A.J.,Alqazzaz, M.,Debaveye, S.,Han, L.,Price, K.,Villalgordo, J.M.,Tresadern, G.,Lynch, J.W.,Lummis, S.C.
The Prokaryote Ligand-Gated Ion Channel ELIC Captured in a Pore Blocker-Bound Conformation by the Alzheimer's Disease Drug Memantine.
Structure, 22:1399-1407, 2014
Cited by
PubMed: 25199693
DOI: 10.1016/j.str.2014.07.013
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.2 Å)
Structure validation

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