2W8F

Aplysia californica AChBP bound to in silico compound 31

Summary for 2W8F

Entry DOI	10.2210/pdb2w8f/pdb
Related	2BR7 2BR8 2BYN 2BYP 2BYQ 2BYR 2BYS 2C9T 2UZ6 2W8E 2W8G
Descriptor	SOLUBLE ACETYLCHOLINE RECEPTOR, (3-EXO)-3-(10,11-DIHYDRO-5H-DIBENZO[A,D][7]ANNULEN-5-YLOXY)-8,8-DIMETHYL-8-AZONIABICYCLO[3.2.1]OCTANE (3 entities in total)
Functional Keywords	receptor, acetylcholine receptor inhibitor, acetylcholine binding protein, postsynaptic neurotoxin, nicotinic acetylcholine receptor-toxin complex, neurotoxin, toxin, amidation, conotoxin
Biological source	APLYSIA CALIFORNICA (CALIFORNIA SEA HARE)
Total number of polymer chains	10
Total formula weight	247582.78
Authors	Ulens, C.,Akdemir, A.,Jongejan, A.,van Elk, R.,Edink, E.,Bertrand, S.,Perrakis, A.,Leurs, R.,Smit, A.B.,Sixma, T.K.,Bertrand, D.,de Esch, I.J. (deposition date: 2009-01-16, release date: 2009-04-14, Last modification date: 2024-02-14)
Primary citation	Ulens, C.,Akdemir, A.,Jongejan, A.,Van Elk, R.,Bertrand, S.,Perrakis, A.,Leurs, R.,Smit, A.B.,Sixma, T.K.,Bertrand, D.,De Esch, I.J. Use of Acetylcholine Binding Protein in the Search for Novel Alpha7 Nicotinic Receptor Ligands. In Silico Docking, Pharmacological Screening, and X- Ray Analysis. J.Med.Chem., 52:2372-, 2009 Cited by PubMed: 19331415 DOI: 10.1021/JM801400G PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation