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1Z3I
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BU of 1z3i by Molmil
Structure of the SWI2/SNF2 chromatin remodeling domain of eukaryotic Rad54
Descriptor: SULFATE ION, ZINC ION, similar to RAD54-like
Authors:Thoma, N.H, Czyzewski, B.K, Alexeev, A.A, Mazin, A.V, Kowalczykowski, S.C, Pavletich, N.P.
Deposit date:2005-03-12
Release date:2005-04-05
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the SWI2/SNF2 chromatin-remodeling domain of eukaryotic Rad54.
Nat.Struct.Mol.Biol., 12, 2005
5REQ
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BU of 5req by Molmil
Methylmalonyl-COA MUTASE, Y89F Mutant, substrate complex
Descriptor: COBALAMIN, GLYCEROL, METHYLMALONYL(CARBADETHIA)-COENZYME A, ...
Authors:Evans, P.R, Thomae, N.H.
Deposit date:1998-08-03
Release date:1998-08-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Stabilization of radical intermediates by an active-site tyrosine residue in methylmalonyl-CoA mutase.
Biochemistry, 37, 1998
1E1C
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BU of 1e1c by Molmil
METHYLMALONYL-COA MUTASE H244A Mutant
Descriptor: COBALAMIN, DESULFO-COENZYME A, METHYLMALONYL-COA MUTASE ALPHA CHAIN, ...
Authors:Evans, P.R, Thoma, N.H.
Deposit date:2000-04-30
Release date:2000-05-07
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Protection of Radical Intermediates at the Active Site of Adenosylcobalamin-Dependent Methylmalonyl-Coa Mutase
Biochemistry, 39, 2000
7OKQ
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BU of 7okq by Molmil
Cryo-EM Structure of the DDB1-DCAF1-CUL4A-RBX1 Complex
Descriptor: Cullin-4A, DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1, ...
Authors:Mohamed, W.I, Schenk, A.D, Kempf, G, Cavadini, S, Thoma, N.H.
Deposit date:2021-05-18
Release date:2021-10-13
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (8.4 Å)
Cite:The CRL4 DCAF1 cullin-RING ubiquitin ligase is activated following a switch in oligomerization state.
Embo J., 40, 2021
5NW5
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BU of 5nw5 by Molmil
Crystal structure of the Rif1 N-terminal domain (RIF1-NTD) from Saccharomyces cerevisiae in complex with DNA
Descriptor: DNA (30-MER), DNA (60-MER), Telomere length regulator protein RIF1
Authors:Bunker, R.D, Reinert, J.K, Shi, T, Thoma, N.H.
Deposit date:2017-05-05
Release date:2017-06-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (6.502 Å)
Cite:Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends.
Nat. Struct. Mol. Biol., 24, 2017
5NVR
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BU of 5nvr by Molmil
Crystal structure of the Rif1 N-terminal domain (RIF1-NTD) from Saccharomyces cerevisiae
Descriptor: Telomere length regulator protein RIF1
Authors:Bunker, R.D, Shi, T, Thoma, N.H.
Deposit date:2017-05-04
Release date:2017-06-14
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3.95 Å)
Cite:Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends.
Nat. Struct. Mol. Biol., 24, 2017
4D10
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BU of 4d10 by Molmil
Crystal structure of the COP9 signalosome
Descriptor: COP9 SIGNALOSOME COMPLEX SUBUNIT 1, COP9 SIGNALOSOME COMPLEX SUBUNIT 2, COP9 SIGNALOSOME COMPLEX SUBUNIT 3, ...
Authors:Bunker, R.D, Lingaraju, G.M, Thoma, N.H.
Deposit date:2014-04-30
Release date:2014-07-23
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystal Structure of the Human Cop9 Signalosome
Nature, 512, 2014
4CGY
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BU of 4cgy by Molmil
Crystal structure of the human topoisomerase III alpha-RMI1 complex
Descriptor: DNA TOPOISOMERASE 3-ALPHA, MAGNESIUM ION, RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1
Authors:Bocquet, N, Bunker, R.D, Thoma, N.H.
Deposit date:2013-11-27
Release date:2014-02-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural and Mechanistic Insight Into Holliday-Junction Dissolution by Topoisomerase Iiialpha and Rmi1
Nat.Struct.Mol.Biol., 21, 2014
4CHT
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BU of 4cht by Molmil
Crystal structure of the human topoisomerase III alpha-RMI1 complex with bound calcium ion
Descriptor: CALCIUM ION, DNA TOPOISOMERASE 3-ALPHA, RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1
Authors:Bocquet, N, Bunker, R.D, Thoma, N.H.
Deposit date:2013-12-04
Release date:2014-02-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structural and Mechanistic Insight Into Holliday-Junction Dissolution by Topoisomerase Iiialpha and Rmi1
Nat.Struct.Mol.Biol., 21, 2014
4CI3
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BU of 4ci3 by Molmil
Structure of the DDB1-CRBN E3 ubiquitin ligase bound to Pomalidomide
Descriptor: DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, S-Pomalidomide, ...
Authors:Fischer, E.S, Boehm, K, Thoma, N.H.
Deposit date:2013-12-05
Release date:2014-07-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Nature, 512, 2014
4WSN
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BU of 4wsn by Molmil
Crystal structure of the COP9 signalosome, a P1 crystal form
Descriptor: COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ...
Authors:Bunker, R.D, Lingaraju, G.M, Thoma, N.H.
Deposit date:2014-10-28
Release date:2015-12-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (5.5 Å)
Cite:Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome.
Nature, 531, 2016
6GVW
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BU of 6gvw by Molmil
Crystal structure of the BRCA1-A complex
Descriptor: BRCA1-A complex subunit Abraxas 1, BRCA1-A complex subunit RAP80, BRISC and BRCA1-A complex member 1, ...
Authors:Bunker, R.D, Rabl, J, Thoma, N.H.
Deposit date:2018-06-21
Release date:2019-07-10
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (3.75 Å)
Cite:Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.
Mol.Cell, 75, 2019
6H0F
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BU of 6h0f by Molmil
Structure of DDB1-CRBN-pomalidomide complex bound to IKZF1(ZF2)
Descriptor: DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1, DNA-binding protein Ikaros, Protein cereblon, ...
Authors:Petzold, G, Bunker, R.D, Thoma, N.H.
Deposit date:2018-07-09
Release date:2018-11-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.
Science, 362, 2018
6H0G
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BU of 6h0g by Molmil
Structure of the DDB1-CRBN-pomalidomide complex bound to ZNF692(ZF4)
Descriptor: DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DDB1 (DNA damage binding protein 1),DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ...
Authors:Bunker, R.D, Petzold, G, Thoma, N.H.
Deposit date:2018-07-09
Release date:2018-11-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (4.25 Å)
Cite:Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.
Science, 362, 2018
6Y5E
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BU of 6y5e by Molmil
Structure of human cGAS (K394E) bound to the nucleosome (focused refinement of cGAS-NCP subcomplex)
Descriptor: Cyclic GMP-AMP synthase, DNA (153-MER), Histone H2A type 2-C, ...
Authors:Pathare, G.R, Cavadini, S, Kempf, G, Thoma, N.H.
Deposit date:2020-02-25
Release date:2020-09-23
Last modified:2020-12-09
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Structural mechanism of cGAS inhibition by the nucleosome.
Nature, 587, 2020
6H3C
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BU of 6h3c by Molmil
Cryo-EM structure of the BRISC complex bound to SHMT2
Descriptor: BRISC and BRCA1-A complex member 1, BRISC and BRCA1-A complex member 2, BRISC complex subunit Abraxas 2, ...
Authors:Bunker, R.D, Rabl, J, Thoma, N.H.
Deposit date:2018-07-18
Release date:2019-07-10
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.
Mol.Cell, 75, 2019
1LTX
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BU of 1ltx by Molmil
Structure of Rab Escort Protein-1 in complex with Rab geranylgeranyl transferase and isoprenoid
Descriptor: AAAA, CHLORIDE ION, FARNESYL, ...
Authors:Pylypenko, O, Rak, A, Reents, R, Niculae, A, Thoma, N.H, Waldmann, H, Schlichting, I, Goody, R.S, Alexandrov, K.
Deposit date:2002-05-21
Release date:2003-05-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of Rab Escort Protein-1 in Complex with Rab Geranylgeranyltransferase
Mol.Cell, 11, 2003
4YM6
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BU of 4ym6 by Molmil
Crystal structure of the human nucleosome containing 6-4PP (outside)
Descriptor: 145-MER DNA, Histone H2A type 1-B/E, Histone H2B type 1-J, ...
Authors:Osakabe, A, Tachiwana, H, Kagawa, W, Horikoshi, N, Matsumoto, S, Hasegawa, M, Matsumoto, N, Toga, T, Yamamoto, J, Hanaoka, F, Thoma, N.H, Sugasawa, K, Iwai, S, Kurumizaka, H.
Deposit date:2015-03-06
Release date:2015-12-02
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.514 Å)
Cite:Structural basis of pyrimidine-pyrimidone (6-4) photoproduct recognition by UV-DDB in the nucleosome
Sci Rep, 5, 2015
4YM5
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BU of 4ym5 by Molmil
Crystal structure of the human nucleosome containing 6-4PP (inside)
Descriptor: 144 mer-DNA, 144-mer DNA, Histone H2A type 1-B/E, ...
Authors:Osakabe, A, Tachiwana, H, Kagawa, W, Horikoshi, N, Matsumoto, S, Hasegawa, M, Matsumoto, N, Toga, T, Yamamoto, J, Hanaoka, F, Thoma, N.H, Sugasawa, K, Iwai, S, Kurumizaka, H.
Deposit date:2015-03-06
Release date:2015-12-02
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (4.005 Å)
Cite:Structural basis of pyrimidine-pyrimidone (6-4) photoproduct recognition by UV-DDB in the nucleosome
Sci Rep, 5, 2015
6YOV
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BU of 6yov by Molmil
OCT4-SOX2-bound nucleosome - SHL+6
Descriptor: DNA (142-MER), Green fluorescent protein,POU domain, class 5, ...
Authors:Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H.
Deposit date:2020-04-15
Release date:2020-05-06
Last modified:2020-07-08
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:Mechanisms of OCT4-SOX2 motif readout on nucleosomes.
Science, 368, 2020
6Y5D
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BU of 6y5d by Molmil
Structure of human cGAS (K394E) bound to the nucleosome
Descriptor: Cyclic GMP-AMP synthase, DNA (153-MER), Histone H2A type 2-A, ...
Authors:Pathare, G.R, Cavadini, S, Kempf, G, Thoma, N.H.
Deposit date:2020-02-25
Release date:2020-09-23
Last modified:2020-12-09
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural mechanism of cGAS inhibition by the nucleosome.
Nature, 587, 2020
8P83
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BU of 8p83 by Molmil
Cryo-EM structure of full-length human UBR5 (homotetramer)
Descriptor: E3 ubiquitin-protein ligase UBR5
Authors:Aguirre, J.D, Kater, L, Kempf, G, Cavadini, S, Thoma, N.H.
Deposit date:2023-05-31
Release date:2023-06-14
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (3.87 Å)
Cite:UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.
Mol.Cell, 83, 2023
8OSK
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BU of 8osk by Molmil
Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL+5.8 (composite map)
Descriptor: Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ...
Authors:Stoos, L, Michael, A.K, Kempf, G, Cavadini, S, Thoma, N.H.
Deposit date:2023-04-19
Release date:2023-05-24
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cooperation between bHLH transcription factors and histones for DNA access.
Nature, 619, 2023
8OSJ
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BU of 8osj by Molmil
Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL-6.2 (DNA conformation 1)
Descriptor: Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ...
Authors:Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N.H.
Deposit date:2023-04-19
Release date:2023-05-24
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:Cooperation between bHLH transcription factors and histones for DNA access.
Nature, 619, 2023
8P82
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BU of 8p82 by Molmil
Cryo-EM structure of dimeric UBR5
Descriptor: E3 ubiquitin-protein ligase UBR5, ZINC ION
Authors:Aguirre, J.D, Kater, L, Kempf, G, Cavadini, S, Thoma, N.H.
Deposit date:2023-05-31
Release date:2023-06-14
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.
Mol.Cell, 83, 2023

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PDB entries from 2024-09-18

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