6H3C

Cryo-EM structure of the BRISC complex bound to SHMT2

Summary for 6H3C

• Entry DOI: 10.2210/pdb6h3c/pdb
• Related: 6GVW
• EMDB information: 0132
• Descriptor: BRISC complex subunit Abraxas 2, Lys-63-specific deubiquitinase BRCC36, BRISC and BRCA1-A complex member 2, ... (7 entities in total)
• Functional Keywords: deubiquitinase complex, dub, lysine-63 linkage specific, brcc36-containing, brca1a binding, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 10
• Total formula weight: 458077.08

Authors

Bunker, R.D.,Rabl, J.,Thoma, N.H. (deposition date: 2018-07-18, release date: 2019-07-10, Last modification date: 2020-07-29)

• Primary citation: Rabl, J.,Bunker, R.D.,Schenk, A.D.,Cavadini, S.,Gill, M.E.,Abdulrahman, W.,Andres-Pons, A.,Luijsterburg, M.S.,Ibrahim, A.F.M.,Branigan, E.,Aguirre, J.D.,Marceau, A.H.,Guerillon, C.,Bouwmeester, T.,Hassiepen, U.,Peters, A.H.F.M.,Renatus, M.,Gelman, L.,Rubin, S.M.,Mailand, N.,van Attikum, H.,Hay, R.T.,Thoma, N.H.; Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.; Mol.Cell, 75:483-497.e9, 2019; PubMed: 31253574; DOI: 10.1016/j.molcel.2019.06.002

Experimental method

ELECTRON MICROSCOPY (3.9 Å)