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6H3C

Cryo-EM structure of the BRISC complex bound to SHMT2

Functional Information from GO Data
ChainGOidnamespacecontents
A0000278biological_processmitotic cell cycle
A0000922cellular_componentspindle pole
A0002931biological_processresponse to ischemia
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0007059biological_processchromosome segregation
A0008017molecular_functionmicrotubule binding
A0008608biological_processattachment of spindle microtubules to kinetochore
A0030496cellular_componentmidbody
A0031593molecular_functionpolyubiquitin modification-dependent protein binding
A0031616cellular_componentspindle pole centrosome
A0036449cellular_componentmicrotubule minus-end
A0051301biological_processcell division
A0070536biological_processprotein K63-linked deubiquitination
A0070552cellular_componentBRISC complex
A0090307biological_processmitotic spindle assembly
B0000151cellular_componentubiquitin ligase complex
B0000152cellular_componentnuclear ubiquitin ligase complex
B0000922cellular_componentspindle pole
B0004843molecular_functioncysteine-type deubiquitinase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0006281biological_processDNA repair
B0006282biological_processregulation of DNA repair
B0006302biological_processdouble-strand break repair
B0006325biological_processchromatin organization
B0006508biological_processproteolysis
B0007095biological_processmitotic G2 DNA damage checkpoint signaling
B0008233molecular_functionpeptidase activity
B0008237molecular_functionmetallopeptidase activity
B0010165biological_processresponse to X-ray
B0010212biological_processresponse to ionizing radiation
B0016579biological_processprotein deubiquitination
B0030234molecular_functionenzyme regulator activity
B0031593molecular_functionpolyubiquitin modification-dependent protein binding
B0044818biological_processmitotic G2/M transition checkpoint
B0045739biological_processpositive regulation of DNA repair
B0046872molecular_functionmetal ion binding
B0051301biological_processcell division
B0061578molecular_functionK63-linked deubiquitinase activity
B0070531cellular_componentBRCA1-A complex
B0070536biological_processprotein K63-linked deubiquitination
B0070552cellular_componentBRISC complex
B0071479biological_processcellular response to ionizing radiation
B0140492molecular_functionmetal-dependent deubiquitinase activity
B0140861biological_processDNA repair-dependent chromatin remodeling
B1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
B2000001biological_processregulation of DNA damage checkpoint
C0000152cellular_componentnuclear ubiquitin ligase complex
C0000268molecular_functionperoxisome targeting sequence binding
C0005164molecular_functiontumor necrosis factor receptor binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006281biological_processDNA repair
C0006282biological_processregulation of DNA repair
C0006302biological_processdouble-strand break repair
C0006325biological_processchromatin organization
C0006915biological_processapoptotic process
C0006974biological_processDNA damage response
C0007095biological_processmitotic G2 DNA damage checkpoint signaling
C0007165biological_processsignal transduction
C0010212biological_processresponse to ionizing radiation
C0031593molecular_functionpolyubiquitin modification-dependent protein binding
C0043066biological_processnegative regulation of apoptotic process
C0044818biological_processmitotic G2/M transition checkpoint
C0045739biological_processpositive regulation of DNA repair
C0051301biological_processcell division
C0070531cellular_componentBRCA1-A complex
C0070536biological_processprotein K63-linked deubiquitination
C0070552cellular_componentBRISC complex
C0071479biological_processcellular response to ionizing radiation
C2000001biological_processregulation of DNA damage checkpoint
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006281biological_processDNA repair
D0006282biological_processregulation of DNA repair
D0006302biological_processdouble-strand break repair
D0006325biological_processchromatin organization
D0007095biological_processmitotic G2 DNA damage checkpoint signaling
D0010212biological_processresponse to ionizing radiation
D0016604cellular_componentnuclear body
D0042802molecular_functionidentical protein binding
D0044818biological_processmitotic G2/M transition checkpoint
D0045739biological_processpositive regulation of DNA repair
D0051301biological_processcell division
D0070531cellular_componentBRCA1-A complex
D0070552cellular_componentBRISC complex
D0071425biological_processhematopoietic stem cell proliferation
D0140861biological_processDNA repair-dependent chromatin remodeling
E0002082biological_processregulation of oxidative phosphorylation
E0003682molecular_functionchromatin binding
E0004372molecular_functionglycine hydroxymethyltransferase activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005743cellular_componentmitochondrial inner membrane
E0005759cellular_componentmitochondrial matrix
E0006544biological_processglycine metabolic process
E0006545biological_processglycine biosynthetic process
E0006563biological_processL-serine metabolic process
E0006564biological_processL-serine biosynthetic process
E0006730biological_processone-carbon metabolic process
E0008284biological_processpositive regulation of cell population proliferation
E0008732molecular_functionL-allo-threonine aldolase activity
E0015630cellular_componentmicrotubule cytoskeleton
E0016597molecular_functionamino acid binding
E0016740molecular_functiontransferase activity
E0019264biological_processglycine biosynthetic process from serine
E0030170molecular_functionpyridoxal phosphate binding
E0034340biological_processresponse to type I interferon
E0035999biological_processtetrahydrofolate interconversion
E0042645cellular_componentmitochondrial nucleoid
E0042802molecular_functionidentical protein binding
E0046653biological_processtetrahydrofolate metabolic process
E0051262biological_processprotein tetramerization
E0051289biological_processprotein homotetramerization
E0070062cellular_componentextracellular exosome
E0070129biological_processregulation of mitochondrial translation
E0070536biological_processprotein K63-linked deubiquitination
E0070552cellular_componentBRISC complex
E1903715biological_processregulation of aerobic respiration
F0000278biological_processmitotic cell cycle
F0000922cellular_componentspindle pole
F0002931biological_processresponse to ischemia
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005813cellular_componentcentrosome
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005874cellular_componentmicrotubule
F0007059biological_processchromosome segregation
F0008017molecular_functionmicrotubule binding
F0008608biological_processattachment of spindle microtubules to kinetochore
F0030496cellular_componentmidbody
F0031593molecular_functionpolyubiquitin modification-dependent protein binding
F0031616cellular_componentspindle pole centrosome
F0036449cellular_componentmicrotubule minus-end
F0051301biological_processcell division
F0070536biological_processprotein K63-linked deubiquitination
F0070552cellular_componentBRISC complex
F0090307biological_processmitotic spindle assembly
G0000151cellular_componentubiquitin ligase complex
G0000152cellular_componentnuclear ubiquitin ligase complex
G0000922cellular_componentspindle pole
G0004843molecular_functioncysteine-type deubiquitinase activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0006281biological_processDNA repair
G0006282biological_processregulation of DNA repair
G0006302biological_processdouble-strand break repair
G0006325biological_processchromatin organization
G0006508biological_processproteolysis
G0007095biological_processmitotic G2 DNA damage checkpoint signaling
G0008233molecular_functionpeptidase activity
G0008237molecular_functionmetallopeptidase activity
G0010165biological_processresponse to X-ray
G0010212biological_processresponse to ionizing radiation
G0016579biological_processprotein deubiquitination
G0030234molecular_functionenzyme regulator activity
G0031593molecular_functionpolyubiquitin modification-dependent protein binding
G0044818biological_processmitotic G2/M transition checkpoint
G0045739biological_processpositive regulation of DNA repair
G0046872molecular_functionmetal ion binding
G0051301biological_processcell division
G0061578molecular_functionK63-linked deubiquitinase activity
G0070531cellular_componentBRCA1-A complex
G0070536biological_processprotein K63-linked deubiquitination
G0070552cellular_componentBRISC complex
G0071479biological_processcellular response to ionizing radiation
G0140492molecular_functionmetal-dependent deubiquitinase activity
G0140861biological_processDNA repair-dependent chromatin remodeling
G1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
G2000001biological_processregulation of DNA damage checkpoint
H0000152cellular_componentnuclear ubiquitin ligase complex
H0000268molecular_functionperoxisome targeting sequence binding
H0005164molecular_functiontumor necrosis factor receptor binding
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006281biological_processDNA repair
H0006282biological_processregulation of DNA repair
H0006302biological_processdouble-strand break repair
H0006325biological_processchromatin organization
H0006915biological_processapoptotic process
H0006974biological_processDNA damage response
H0007095biological_processmitotic G2 DNA damage checkpoint signaling
H0007165biological_processsignal transduction
H0010212biological_processresponse to ionizing radiation
H0031593molecular_functionpolyubiquitin modification-dependent protein binding
H0043066biological_processnegative regulation of apoptotic process
H0044818biological_processmitotic G2/M transition checkpoint
H0045739biological_processpositive regulation of DNA repair
H0051301biological_processcell division
H0070531cellular_componentBRCA1-A complex
H0070536biological_processprotein K63-linked deubiquitination
H0070552cellular_componentBRISC complex
H0071479biological_processcellular response to ionizing radiation
H2000001biological_processregulation of DNA damage checkpoint
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0006281biological_processDNA repair
I0006282biological_processregulation of DNA repair
I0006302biological_processdouble-strand break repair
I0006325biological_processchromatin organization
I0007095biological_processmitotic G2 DNA damage checkpoint signaling
I0010212biological_processresponse to ionizing radiation
I0016604cellular_componentnuclear body
I0042802molecular_functionidentical protein binding
I0044818biological_processmitotic G2/M transition checkpoint
I0045739biological_processpositive regulation of DNA repair
I0051301biological_processcell division
I0070531cellular_componentBRCA1-A complex
I0070552cellular_componentBRISC complex
I0071425biological_processhematopoietic stem cell proliferation
I0140861biological_processDNA repair-dependent chromatin remodeling
J0002082biological_processregulation of oxidative phosphorylation
J0003682molecular_functionchromatin binding
J0004372molecular_functionglycine hydroxymethyltransferase activity
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005737cellular_componentcytoplasm
J0005739cellular_componentmitochondrion
J0005743cellular_componentmitochondrial inner membrane
J0005759cellular_componentmitochondrial matrix
J0006544biological_processglycine metabolic process
J0006545biological_processglycine biosynthetic process
J0006563biological_processL-serine metabolic process
J0006564biological_processL-serine biosynthetic process
J0006730biological_processone-carbon metabolic process
J0008284biological_processpositive regulation of cell population proliferation
J0008732molecular_functionL-allo-threonine aldolase activity
J0015630cellular_componentmicrotubule cytoskeleton
J0016597molecular_functionamino acid binding
J0016740molecular_functiontransferase activity
J0019264biological_processglycine biosynthetic process from serine
J0030170molecular_functionpyridoxal phosphate binding
J0034340biological_processresponse to type I interferon
J0035999biological_processtetrahydrofolate interconversion
J0042645cellular_componentmitochondrial nucleoid
J0042802molecular_functionidentical protein binding
J0046653biological_processtetrahydrofolate metabolic process
J0051262biological_processprotein tetramerization
J0051289biological_processprotein homotetramerization
J0070062cellular_componentextracellular exosome
J0070129biological_processregulation of mitochondrial translation
J0070536biological_processprotein K63-linked deubiquitination
J0070552cellular_componentBRISC complex
J1903715biological_processregulation of aerobic respiration
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN B 401
ChainResidue
BHIS122
BHIS124
BASP135
BHOH1000

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN G 401
ChainResidue
GHIS122
GHIS124
GASP135
GHOH1000

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ELYS82
JLYS160
JLYS175
JLYS276
JLYS335
JLYS443
JLYS448
JLYS453
ELYS160
ELYS175
ELYS276
ELYS335
ELYS443
ELYS448
ELYS453
JLYS82

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:29180469
ChainResidueDetails
ELYS259
JLYS259

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ESER449
JSER449

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER49
ISER49

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
DSER57
ISER57

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
DSER62
ISER62

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332
ChainResidueDetails
DTHR65
ITHR65

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:24275569
ChainResidueDetails
DSER66
ISER66

225158

PDB entries from 2024-09-18

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