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1AD5
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BU of 1ad5 by Molmil
SRC FAMILY KINASE HCK-AMP-PNP COMPLEX
Descriptor: CALCIUM ION, HAEMATOPOETIC CELL KINASE HCK, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Sicheri, F, Moarefi, I, Kuriyan, J.
Deposit date:1997-02-20
Release date:1997-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the Src family tyrosine kinase Hck.
Nature, 385, 1997
2HCK
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BU of 2hck by Molmil
SRC FAMILY KINASE HCK-QUERCETIN COMPLEX
Descriptor: 3,5,7,3',4'-PENTAHYDROXYFLAVONE, CALCIUM ION, HEMATOPOETIC CELL KINASE HCK
Authors:Sicheri, F, Moarefi, I, Kuriyan, J.
Deposit date:1997-02-25
Release date:1997-08-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of the Src family tyrosine kinase Hck.
Nature, 385, 1997
1WFB
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BU of 1wfb by Molmil
WINTER FLOUNDER ANTIFREEZE PROTEIN ISOFORM HPLC6 AT-180 DEGREES C
Descriptor: ANTIFREEZE PROTEIN ISOFORM HPLC6
Authors:Yang, D.S.C, Sicheri, F.
Deposit date:1995-04-03
Release date:1995-06-03
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Ice-binding structure and mechanism of an antifreeze protein from winter flounder.
Nature, 375, 1995
1WFA
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BU of 1wfa by Molmil
WINTER FLOUNDER ANTIFREEZE PROTEIN ISOFORM HPLC6 AT 4 DEGREES C
Descriptor: ANTIFREEZE PROTEIN ISOFORM HPLC6
Authors:Yang, D.S.C, Sicheri, F.
Deposit date:1995-04-03
Release date:1995-06-03
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Ice-binding structure and mechanism of an antifreeze protein from winter flounder.
Nature, 375, 1995
3RZ3
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BU of 3rz3 by Molmil
Human Cdc34 E2 in complex with CC0651 inhibitor
Descriptor: 4,5-dideoxy-5-(3',5'-dichlorobiphenyl-4-yl)-4-[(methoxyacetyl)amino]-L-arabinonic acid, Ubiquitin-conjugating enzyme E2 R1
Authors:Ceccarelli, D.F, Webb, D.R, Sicheri, F.
Deposit date:2011-05-11
Release date:2011-07-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:An allosteric inhibitor of the human cdc34 ubiquitin conjugating enzyme
Cell(Cambridge,Mass.), 145, 2011
8BW8
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BU of 8bw8 by Molmil
Crystal structure of the dCNK-SAM-CRIC-PDZ/dHYP-SAM complex
Descriptor: Connector enhancer of KSR protein CNK, GLYCEROL, Protein aveugle
Authors:Maisonneuve, P, Kurinov, I, Sicheri, F.
Deposit date:2022-12-06
Release date:2024-02-21
Last modified:2024-07-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.
Nat.Struct.Mol.Biol., 31, 2024
8BW9
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BU of 8bw9 by Molmil
Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP
Descriptor: Connector enhancer of KSR protein CNK, Dual specificity mitogen-activated protein kinase kinase dSOR1, KSR, ...
Authors:Maisonneuve, P, Fronzes, R, Sicheri, F.
Deposit date:2022-12-06
Release date:2024-02-21
Last modified:2024-07-31
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.
Nat.Struct.Mol.Biol., 31, 2024
2A1A
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BU of 2a1a by Molmil
PKR kinase domain-eIF2alpha Complex
Descriptor: Eukaryotic translation initiation factor 2 alpha subunit, Interferon-induced, double-stranded RNA-activated protein kinase
Authors:Dar, A.C, Dever, T.E, Sicheri, F.
Deposit date:2005-06-19
Release date:2005-09-27
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Higher-Order Substrate Recognition of eIF2alpha by the RNA-Dependent Protein Kinase PKR.
Cell(Cambridge,Mass.), 122, 2005
8E23
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BU of 8e23 by Molmil
Human DNA polymerase theta in complex with allosteric inhibitor
Descriptor: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*GP*TP*CP*CP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*C)-3'), DNA (5'-D(*GP*C*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*G)-3'), ...
Authors:Mader, P, Pau, V.P.T, Sicheri, F.
Deposit date:2022-08-13
Release date:2022-09-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta.
J.Med.Chem., 65, 2022
8E24
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BU of 8e24 by Molmil
Human DNA polymerase theta in complex with allosteric inhibitor
Descriptor: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-[2,4-bis(trifluoromethyl)phenyl]-N-phenyl-N-[3-(pyridazin-3-yl)prop-2-yn-1-yl]acetamide, DNA, ...
Authors:Mader, P, Pau, V.P.T, Sicheri, F.
Deposit date:2022-08-13
Release date:2022-09-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta.
J.Med.Chem., 65, 2022
2D3D
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BU of 2d3d by Molmil
crystal structure of the RNA binding SAM domain of saccharomyces cerevisiae Vts1
Descriptor: CALCIUM ION, Vts1 protein
Authors:Aviv, T, Amborski, A.N, Zhao, X.S, Kwan, J.J, Johnson, P.E, Sicheri, F, Donaldson, L.W.
Deposit date:2005-09-27
Release date:2006-02-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The NMR and X-ray Structures of the Saccharomyces cerevisiae Vts1 SAM Domain Define a Surface for the Recognition of RNA Hairpins
J.Mol.Biol., 356, 2006
2K8Y
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BU of 2k8y by Molmil
Solution NMR Structure of Cgi121 from Methanococcus jannaschii. Northeast Structural Genomics Consortium Target MJ0187
Descriptor: Uncharacterized protein MJ0187
Authors:Rumpel, S, Fares, C, Neculai, D, Arrowsmith, C, Montelione, G.T, Sicheri, F, Northeast Structural Genomics Consortium (NESG)
Deposit date:2008-09-25
Release date:2008-11-04
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.
Mol.Cell, 32, 2008
2KIS
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BU of 2kis by Molmil
Solution structure of CA150 FF1 domain and FF1-FF2 interdomain linker
Descriptor: Transcription elongation regulator 1
Authors:Murphy, J.M, Hansen, D, Wiesner, S, Muhandiram, D, Borg, M, Smith, M.J, Sicheri, F, Kay, L.E, Forman-Kay, J.D, Pawson, T.
Deposit date:2009-05-08
Release date:2009-09-08
Last modified:2024-05-08
Method:SOLUTION NMR
Cite:Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays.
J.Mol.Biol., 393, 2009
4QLB
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BU of 4qlb by Molmil
Structural Basis for the Recruitment of Glycogen Synthase by Glycogenin
Descriptor: GLYCEROL, Probable glycogen [starch] synthase, Protein GYG-1, ...
Authors:Zeqiraj, E, Judd, A, Sicheri, F.
Deposit date:2014-06-11
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the recruitment of glycogen synthase by glycogenin.
Proc.Natl.Acad.Sci.USA, 111, 2014
5IBK
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BU of 5ibk by Molmil
Skp1-F-box in complex with a ubiquitin variant
Descriptor: F-box/WD repeat-containing protein 7, Polyubiquitin-B, S-phase kinase-associated protein 1,S-phase kinase-associated protein 1
Authors:Orlicky, S, Sicheri, F.
Deposit date:2016-02-22
Release date:2016-03-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.
Proc.Natl.Acad.Sci.USA, 113, 2016
7RMA
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BU of 7rma by Molmil
Structure of the fourth UIM (Ubiquitin Interacting Motif) of ANKRD13D in complex with a high affinity UbV (Ubiquitin Variant)
Descriptor: Ankyrin repeat domain-containing protein 13D, SODIUM ION, SULFATE ION, ...
Authors:Singer, A.U, Manczyk, N, Veggiani, G, Sicheri, F, Sidhu, S.S.
Deposit date:2021-07-27
Release date:2022-05-11
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Panel of Engineered Ubiquitin Variants Targeting the Family of Human Ubiquitin Interacting Motifs.
Acs Chem.Biol., 17, 2022
3BS7
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BU of 3bs7 by Molmil
Crystal structure of the Sterile Alpha Motif (SAM) domain of Hyphen/Aveugle
Descriptor: Protein aveugle
Authors:Rajakulendran, T, Sicheri, F.
Deposit date:2007-12-22
Release date:2008-02-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling.
Proc.Natl.Acad.Sci.USA, 105, 2008
1B0X
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BU of 1b0x by Molmil
THE CRYSTAL STRUCTURE OF AN EPH RECEPTOR SAM DOMAIN REVEALS A MECHANISM FOR MODULAR DIMERIZATION.
Descriptor: PROTEIN (EPHA4 RECEPTOR TYROSINE KINASE)
Authors:Stapleton, D, Balan, I, Pawson, T, Sicheri, F.
Deposit date:1998-11-14
Release date:1999-05-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization.
Nat.Struct.Biol., 6, 1999
8D6E
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BU of 8d6e by Molmil
Crystal Structure of Human Myt1 Kinase domain Bounded with RP-6306
Descriptor: (1P)-2-amino-1-(3-hydroxy-2,6-dimethylphenyl)-5,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide, 1,2-ETHANEDIOL, GLYCEROL, ...
Authors:Pau, V.P.T, Mao, D.Y.L, Mader, P, Orlicky, S, Sicheri, F.
Deposit date:2022-06-06
Release date:2022-07-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.
J.Med.Chem., 65, 2022
8D6D
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BU of 8d6d by Molmil
Crystal Structure of Human Myt1 Kinase domain Bounded with compound 39
Descriptor: (1P)-2-amino-5-bromo-1-(3-hydroxy-2,6-dimethylphenyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide, 1,2-ETHANEDIOL, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, ...
Authors:Pau, V.P.T, Mao, D.Y.L, Mader, P, Orlicky, S, Sicheri, F.
Deposit date:2022-06-06
Release date:2022-07-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.
J.Med.Chem., 65, 2022
8D6F
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BU of 8d6f by Molmil
Crystal Structure of Human Myt1 Kinase domain Bounded with Eph receptor inhibitor / compound 41
Descriptor: (1M)-2-amino-1-(5-hydroxy-2-methylphenyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, SULFATE ION
Authors:Pau, V.P.T, Mao, D.Y.L, Mader, P, Orlicky, S, Sicheri, F.
Deposit date:2022-06-06
Release date:2022-07-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.
J.Med.Chem., 65, 2022
8D6C
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BU of 8d6c by Molmil
Crystal Structure of Human Myt1 Kinase domain Bounded with compound 28
Descriptor: (1P)-2-amino-6-bromo-1-(3-hydroxy-2,6-dimethylphenyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide, 1,2-ETHANEDIOL, GLYCEROL, ...
Authors:Pau, V.P.T, Mao, D.Y.L, Mader, P, Orlicky, S, Sicheri, F.
Deposit date:2022-06-06
Release date:2022-07-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.
J.Med.Chem., 65, 2022
4DDG
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BU of 4ddg by Molmil
Crystal structure of human OTUB1/UbcH5b~Ub/Ub
Descriptor: Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 D2, Ubiquitin thioesterase OTUB1
Authors:Juang, Y.C, Sanches, M, Sicheri, F.
Deposit date:2012-01-18
Release date:2012-02-22
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.2987 Å)
Cite:OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function.
Mol.Cell, 45, 2012
4DDI
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BU of 4ddi by Molmil
Crystal structure of human OTUB1/UbcH5b~Ub/Ub
Descriptor: Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 D2, Ubiquitin thioesterase OTUB1
Authors:Juang, Y.C, Sanches, M, Sicheri, F.
Deposit date:2012-01-18
Release date:2012-02-22
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.802 Å)
Cite:OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function.
Mol.Cell, 45, 2012
6UUO
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BU of 6uuo by Molmil
Crystal structure of BRAF kinase domain bound to the PROTAC P4B
Descriptor: N-(3-{5-[(1-acetylpiperidin-4-yl)(methyl)amino]-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl}-2,4-difluorophenyl)propane-1-sulfonamide, Serine/threonine-protein kinase B-raf
Authors:Maisonneuve, P, Posternak, G, Kurinov, I, Sicheri, F.
Deposit date:2019-10-30
Release date:2020-06-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.288 Å)
Cite:Functional characterization of a PROTAC directed against BRAF mutant V600E.
Nat.Chem.Biol., 16, 2020

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