8D6F

Crystal Structure of Human Myt1 Kinase domain Bounded with Eph receptor inhibitor / compound 41

Summary for 8D6F

Entry DOI	10.2210/pdb8d6f/pdb
Descriptor	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, SULFATE ION, (1M)-2-amino-1-(5-hydroxy-2-methylphenyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide, ... (4 entities in total)
Functional Keywords	kinase inhibitor complex, signaling protein, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	69855.08
Authors	Pau, V.P.T.,Mao, D.Y.L.,Mader, P.,Orlicky, S.,Sicheri, F. (deposition date: 2022-06-06, release date: 2022-07-27, Last modification date: 2023-10-18)
Primary citation	Szychowski, J.,Papp, R.,Dietrich, E.,Liu, B.,Vallee, F.,Leclaire, M.E.,Fourtounis, J.,Martino, G.,Perryman, A.L.,Pau, V.,Yin, S.Y.,Mader, P.,Roulston, A.,Truchon, J.F.,Marshall, C.G.,Diallo, M.,Duffy, N.M.,Stocco, R.,Godbout, C.,Bonneau-Fortin, A.,Kryczka, R.,Bhaskaran, V.,Mao, D.,Orlicky, S.,Beaulieu, P.,Turcotte, P.,Kurinov, I.,Sicheri, F.,Mamane, Y.,Gallant, M.,Black, W.C. Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J.Med.Chem., 65:10251-10284, 2022 Cited by PubMed: 35880755 DOI: 10.1021/acs.jmedchem.2c00552 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.49 Å)

Structure validation