Author results

1EKO
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PIG ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR
Descriptor:ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [2,6-DIMETHYL-4-(2-O-TOLYL-ACETYLAMINO)-BENZENESULFONYL]-GLYCINE
Authors:Podjarny, A.
Deposit date:2000-03-09
Release date:2000-05-10
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of human aldose reductase bound to the inhibitor IDD384.
Acta Crystallogr.,Sect.D, 56, 2000
5NR8
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CRYSTAL STRUCTURE OF HUMAN CHITOTRIOSIDASE-1 (HCHIT) CATALYTIC DOMAIN IN COMPLEX WITH COMPOUND 7A
Descriptor:Chitotriosidase-1, 1-(3-azanyl-1~{H}-1,2,4-triazol-5-yl)-~{N}-[2-(4-bromophenyl)ethyl]-~{N}-methyl-piperidin-4-amine, GLYCEROL
Authors:Podjarny, A., Fadel, F., Golebiowski, A.
Deposit date:2017-04-22
Release date:2018-02-21
Method:X-RAY DIFFRACTION (1.349 Å)
Cite:Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma.
J. Med. Chem., 61, 2018
1EL3
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HUMAN ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR
Descriptor:ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [2,6-DIMETHYL-4-(2-O-TOLYL-ACETYLAMINO)-BENZENESULFONYL]-GLYCINE
Authors:Podjarny, A.
Deposit date:2000-03-13
Release date:2000-05-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The structure of human aldose reductase bound to the inhibitor IDD384.
Acta Crystallogr.,Sect.D, 56, 2000
1AH4
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PIG ALDOSE REDUCTASE, HOLO FORM
Descriptor:ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Moras, D., Podjarny, A.
Deposit date:1997-04-12
Release date:1998-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil.
Structure, 5, 1997
5NRF
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CRYSTAL STRUCTURE OF HUMAN CHITOTRIOSIDASE-1 (HCHIT) CATALYTIC DOMAIN IN COMPLEX WITH COMPOUND 7I
Descriptor:Chitotriosidase-1, 1-(3-azanyl-1~{H}-1,2,4-triazol-5-yl)-~{N}-[2-(4-chlorophenyl)ethyl]-~{N}-(phenylmethyl)piperidin-4-amine, GLYCEROL
Authors:Mazur, M., Olczak, J., Olejniczak, S., Koralewski, R., Czestkowski, W., Jedrzejczak, A., Golab, J., Dzwonek, K., Dymek, B., Sklepkiewicz, P., Zagozdzon, A., Noonan, T., Mahboubi, K., Conway, B., Sheeler, R., Beckett, P., Hungerford, W.M., Podjarny, A., Mitschler, A., Cousido-Siah, A., Fadel, F., Golebiowski, A.
Deposit date:2017-04-22
Release date:2018-03-28
Method:X-RAY DIFFRACTION (1.447 Å)
Cite:Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma.
J. Med. Chem., 61, 2018
1DLA
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NOVEL NADPH-BINDING DOMAIN REVEALED BY THE CRYSTAL STRUCTURE OF ALDOSE REDUCTASE
Descriptor:ALDOSE REDUCTASE
Authors:Rondeau, J.-M., Tete-Favier, F., Podjarny, A., Reymann, J.-M., Barth, P., Biellmann, J.-F., Moras, D.
Deposit date:1993-02-08
Release date:1994-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Novel NADPH-binding domain revealed by the crystal structure of aldose reductase.
Nature, 355, 1992
1RNA
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CRYSTALLOGRAPHIC STRUCTURE OF AN RNA HELIX: [U(U-A)6A]2
Descriptor:RNA (5'-R(*UP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*A)-3')
Authors:Dock-Bregeon, A.C., Chevrier, B., Podjarny, A., Johnson, J., De Bear, J.S., Gough, G.R., Gilham, P.T., Moras, D.
Deposit date:1990-02-01
Release date:1991-04-15
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystallographic structure of an RNA helix: [U(UA)6A]2.
J.Mol.Biol., 209, 1989
1US0
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HUMAN ALDOSE REDUCTASE IN COMPLEX WITH NADP+ AND THE INHIBITOR IDD594 AT 0.66 ANGSTROM
Descriptor:ALDOSE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, IDD594, ...
Authors:Howard, E.I., Sanishvili, R., Cachau, R.E., Mitschler, A., Chevrier, B., Barth, P., Lamour, V., Van Zandt, M., Sibley, E., Bon, C., Moras, D., Schneider, T.R., Joachimiak, A., Podjarny, A.
Deposit date:2003-11-16
Release date:2004-05-07
Last modified:2014-03-05
Method:X-RAY DIFFRACTION (0.66 Å)
Cite:Ultrahigh Resolution Drug Design I: Details of Interactions in Human Aldose Reductase-Inhibitor Complex at 0.66 A.
Proteins, 55, 2004
2AGT
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ALDOSE REDUCTASE MUTANT LEU 300 PRO COMPLEXED WITH FIDARESTAT
Descriptor:Aldose reductase, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Petrova, T., Steuber, H., Hazemann, I., Cousido-Siah, A., Mitschler, A., Chung, R., Oka, M., Klebe, G., El-Kabbani, O., Joachimiak, A., Podjarny, A.
Deposit date:2005-07-27
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1 Å)
Cite:Factorizing Selectivity Determinants of Inhibitor Binding toward Aldose and Aldehyde Reductases: Structural and Thermodynamic Properties of the Aldose Reductase Mutant Leu300Pro-Fidarestat Complex
J.Med.Chem., 48, 2005
2I16
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HUMAN ALDOSE REDUCTASE IN COMPLEX WITH NADP+ AND THE INHIBITOR IDD594 AT TEMPERATURE OF 15K
Descriptor:Aldose reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, IDD594, ...
Authors:Petrova, T., Ginell, S., Mitshler, A., Hasemann, I., Schneider, T., Cousido, A., Lunin, V.Y., Joachimiak, A., Podjarny, A.
Deposit date:2006-08-13
Release date:2006-08-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.81 Å)
Cite:Ultrahigh-resolution study of protein atomic displacement parameters at cryotemperatures obtained with a helium cryostat.
Acta Crystallogr.,Sect.D, 62, 2006
2I17
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HUMAN ALDOSE REDUCTASE IN COMPLEX WITH NADP+ AND THE INHIBITOR IDD594 AT TEMPERATURE OF 60K
Descriptor:Aldose reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, IDD594, ...
Authors:Petrova, T., Ginell, S., Mitshler, A., Hasemann, I., Schneider, T., Cousido, A., Lunin, V.Y., Joachimiak, A., Podjarny, A.
Deposit date:2006-08-13
Release date:2006-08-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.81 Å)
Cite:Ultrahigh-resolution study of protein atomic displacement parameters at cryotemperatures obtained with a helium cryostat.
Acta Crystallogr.,Sect.D, 62, 2006
2PEV
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COMPLEX OF ALDOSE REDUCTASE WITH NADP+ AND SIMALTANEOUSLY BOUND COMPETETIVE INHIBITORS FIDARESTAT AND IDD594. CONCENTRATION OF FIDARESTAT IN SOAKING SOLUTION EXCEEDS CONCENTRATION OF IDD594.
Descriptor:Aldose reductase, CHLORIDE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Petrova, T., Hazemann, I., Cousido, A., Mitschler, A., Ginell, S., Joachimiak, A., Podjarny, A.
Deposit date:2007-04-03
Release date:2007-04-17
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (0.9 Å)
Cite:Crystal packing modifies ligand binding affinity: The case of aldose reductase.
Proteins, 80, 2012
2PF8
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COMPLEX OF ALDOSE REDUCTASE WITH NADP+ AND SIMALTANEOUSLY BOUND COMPETETIVE INHIBITORS FIDARESTAT AND IDD594. CONCENTRATION OF FIDARESTAT IN SOAKING SOLUTION IS EQUAL TO CONCENTRATION OF IDD594.
Descriptor:Aldose reductase, CHLORIDE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Petrova, T., Hazemann, I., Cousido, A., Mitschler, A., Ginell, S., Joachimiak, A., Podjarny, A.
Deposit date:2007-04-04
Release date:2007-04-17
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (0.85 Å)
Cite:Crystal packing modifies ligand binding affinity: The case of aldose reductase.
Proteins, 80, 2012
2PFH
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COMPLEX OF ALDOSE REDUCTASE WITH NADP+ AND SIMALTANEOUSLY BOUND COMPETETIVE INHIBITORS FIDARESTAT AND IDD594. CONCENTRATION OF FIDARESTAT IN SOAKING SOLUTION IS LESS THAN CONCENTRATION OF IDD594.
Descriptor:Aldose reductase, CHLORIDE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Petrova, T., Hazemann, I., Cousido, A., Mitschler, A., Ginell, S., Joachimiak, A., Podjarny, A.
Deposit date:2007-04-05
Release date:2007-04-17
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (0.85 Å)
Cite:Crystal packing modifies ligand binding affinity: The case of aldose reductase.
Proteins, 80, 2012
2QXW
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PERDEUTERATED ALR2 IN COMPLEX WITH IDD594
Descriptor:Aldose reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, IDD594, ...
Authors:Blakeley, M.P., Ruiz, F., Cachau, R., Hazemann, I., Meilleur, F., Mitschler, A., Ginell, S., Afonine, P., Ventura, O., Cousido-Siah, A., Joachimiak, A., Myles, D., Podjarny, A.
Deposit date:2007-08-13
Release date:2008-01-22
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (0.8 Å)
Cite:Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2R24
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HUMAN ALDOSE REDUCTASE STRUCTURE
Descriptor:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, IDD594
Authors:Blakeley, M.P., Ruiz, F., Cachau, R., Hazemann, I., Meilleur, F., Mitschler, A., Ginell, S., Afonine, P., Ventura, O.N., Cousido-Siah, A., Haertlein, M., Joachimiak, A., Myles, D., Podjarny, A.
Deposit date:2007-08-24
Release date:2008-12-23
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.752 Å), NEUTRON DIFFRACTION
Cite:Quantum model of catalysis based on mobile proton revealed by subatomic X-Ray and neutron diffraction studies of h-Aldose Reductase
Proc.Natl.Acad.Sci.USA, 105, 2008
3MTY
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COMPARISON OF THE CHARACTER AND THE SPEED OF X-RAY-INDUCED STRUCTURAL CHANGES OF PORCINE PANCREATIC ELASTASE AT TWO TEMPERATURES, 100 AND 15K. THE DATA SET WAS COLLECTED FROM REGION A OF THE CRYSTAL. FIRST STEP OF RADIATION DAMAGE
Descriptor:Chymotrypsin-like elastase family member 1, SODIUM ION, SULFATE ION
Authors:Petrova, T., Ginell, S., Mitschler, A., Cousido-Siah, A., Hazemann, I., Podjarny, A., Joachimiak, A.
Deposit date:2010-05-01
Release date:2010-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.101 Å)
Cite:X-ray-induced deterioration of disulfide bridges at atomic resolution.
Acta Crystallogr.,Sect.D, 66, 2010
3MU0
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COMPARISON OF THE CHARACTER AND THE SPEED OF X-RAY-INDUCED STRUCTURAL CHANGES OF PORCINE PANCREATIC ELASTASE AT TWO TEMPERATURES, 100 AND 15K. THE DATA SET WAS COLLECTED FROM REGION A OF THE CRYSTAL. THIRD STEP OF RADIATION DAMAGE
Descriptor:Chymotrypsin-like elastase family member 1, SODIUM ION, SULFATE ION
Authors:Petrova, T., Ginell, S., Mitschler, A., Cousido-Siah, A., Hazemann, I., Podjarny, A., Joachimiak, A.
Deposit date:2010-05-01
Release date:2010-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:X-ray-induced deterioration of disulfide bridges at atomic resolution.
Acta Crystallogr.,Sect.D, 66, 2010
3MU1
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COMPARISON OF THE CHARACTER AND THE SPEED OF X-RAY-INDUCED STRUCTURAL CHANGES OF PORCINE PANCREATIC ELASTASE AT TWO TEMPERATURES, 100 AND 15K. THE DATA SET WAS COLLECTED FROM REGION A OF THE CRYSTAL. FIFTH STEP OF RADIATION DAMAGE
Descriptor:Chymotrypsin-like elastase family member 1, SODIUM ION, SULFATE ION
Authors:Petrova, T., Ginell, S., Mitschler, A., Cousido-Siah, A., Hazemann, I., Podjarny, A., Joachimiak, A.
Deposit date:2010-05-01
Release date:2010-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:X-ray-induced deterioration of disulfide bridges at atomic resolution.
Acta Crystallogr.,Sect.D, 66, 2010
3MU4
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COMPARISON OF THE CHARACTER AND THE SPEED OF X-RAY-INDUCED STRUCTURAL CHANGES OF PORCINE PANCREATIC ELASTASE AT TWO TEMPERATURES, 100 AND 15K. THE DATA SET WAS COLLECTED FROM REGION B OF THE CRYSTAL. FIRST STEP OF RADIATION DAMAGE
Descriptor:Chymotrypsin-like elastase family member 1, SODIUM ION, SULFATE ION
Authors:Petrova, T., Ginell, S., Mitschler, A., Cousido-Siah, A., Hazemann, I., Podjarny, A., Joachimiak, A.
Deposit date:2010-05-01
Release date:2010-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.101 Å)
Cite:X-ray-induced deterioration of disulfide bridges at atomic resolution.
Acta Crystallogr.,Sect.D, 66, 2010
3MU5
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COMPARISON OF THE CHARACTER AND THE SPEED OF X-RAY-INDUCED STRUCTURAL CHANGES OF PORCINE PANCREATIC ELASTASE AT TWO TEMPERATURES, 100 AND 15K. THE DATA SET WAS COLLECTED FROM REGION B OF THE CRYSTAL. THIRD STEP OF RADIATION DAMAGE
Descriptor:Chymotrypsin-like elastase family member 1, SODIUM ION, SULFATE ION
Authors:Petrova, T., Ginell, S., Mitschler, A., Cousido-Siah, A., Hazemann, I., Podjarny, A., Joachimiak, A.
Deposit date:2010-05-01
Release date:2010-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.404 Å)
Cite:X-ray-induced deterioration of disulfide bridges at atomic resolution.
Acta Crystallogr.,Sect.D, 66, 2010
3MU8
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COMPARISON OF THE CHARACTER AND THE SPEED OF X-RAY-INDUCED STRUCTURAL CHANGES OF PORCINE PANCREATIC ELASTASE AT TWO TEMPERATURES, 100 AND 15K. THE DATA SET WAS COLLECTED FROM REGION B OF THE CRYSTAL. FIFTH STEP OF RADIATION DAMAGE
Descriptor:Chymotrypsin-like elastase family member 1, SODIUM ION, SULFATE ION
Authors:Petrova, T., Ginell, S., Mitschler, A., Cousido-Siah, A., Hazemann, I., Podjarny, A., Joachimiak, A.
Deposit date:2010-05-02
Release date:2010-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.553 Å)
Cite:X-ray-induced deterioration of disulfide bridges at atomic resolution.
Acta Crystallogr.,Sect.D, 66, 2010
3ODD
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COMPARISON OF THE CHARACTER AND THE SPEED OF X-RAY-INDUCED STRUCTURAL CHANGES OF PORCINE PANCREATIC ELASTASE AT TWO TEMPERATURES, 100 AND 15K. THE DATA SET WAS COLLECTED FROM REGION B OF THE CRYSTAL. SECOND STEP OF RADIATION DAMAGE
Descriptor:Chymotrypsin-like elastase family member 1, SODIUM ION, SULFATE ION
Authors:Petrova, T., Ginell, S., Mitschler, A., Cousido-Siah, A., Hazemann, I., Podjarny, A., Joachimiak, A.
Deposit date:2010-08-11
Release date:2010-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:X-ray-induced deterioration of disulfide bridges at atomic resolution.
Acta Crystallogr.,Sect.D, 66, 2010
3ODF
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COMPARISON OF THE CHARACTER AND THE SPEED OF X-RAY-INDUCED STRUCTURAL CHANGES OF PORCINE PANCREATIC ELASTASE AT TWO TEMPERATURES, 100 AND 15K. THE DATA SET WAS COLLECTED FROM REGION A OF THE CRYSTAL. SECOND STEP OF RADIATION DAMAGE
Descriptor:Chymotrypsin-like elastase family member 1, SODIUM ION, SULFATE ION
Authors:Petrova, T., Ginell, S., Mitschler, A., Cousido-Siah, A., Hazemann, I., Podjarny, A., Joachimiak, A.
Deposit date:2010-08-11
Release date:2010-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:X-ray-induced deterioration of disulfide bridges at atomic resolution.
Acta Crystallogr.,Sect.D, 66, 2010
3PP6
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REP1-NXSQ FATTY ACID TRANSPORTER Y128F MUTANT
Descriptor:ReP1-NCXSQ, PALMITOLEIC ACID
Authors:Berberian, G., Bollo, M., Howard, E., Cousido-Siah, A., Mitschler, A., Ayoub, D., Sanglier-Cianferani, S., Van Dorsselaer, A., DiPolo, R., Beauge, L., Petrova, T., Schulze-Briese, C., Wang, M., Podjarny, A.
Deposit date:2010-11-24
Release date:2011-12-28
Last modified:2018-08-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and functional studies of ReP1-NCXSQ, a protein regulating the squid nerve Na+/Ca2+ exchanger.
Acta Crystallogr.,Sect.D, 68, 2012