2AGT

Aldose Reductase Mutant Leu 300 Pro complexed with Fidarestat

Summary for 2AGT

Entry DOI	10.2210/pdb2agt/pdb
Related	1PWM
Descriptor	Aldose reductase, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
Functional Keywords	oxidoreductase, nadp, fidarestat
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15121
Total number of polymer chains	1
Total formula weight	37414.78
Authors	Petrova, T.,Steuber, H.,Hazemann, I.,Cousido-Siah, A.,Mitschler, A.,Chung, R.,Oka, M.,Klebe, G.,El-Kabbani, O.,Joachimiak, A.,Podjarny, A. (deposition date: 2005-07-27, release date: 2005-09-20, Last modification date: 2023-08-23)
Primary citation	Petrova, T.,Steuber, H.,Hazemann, I.,Cousido-Siah, A.,Mitschler, A.,Chung, R.,Oka, M.,Klebe, G.,El-Kabbani, O.,Joachimiak, A.,Podjarny, A. Factorizing Selectivity Determinants of Inhibitor Binding toward Aldose and Aldehyde Reductases: Structural and Thermodynamic Properties of the Aldose Reductase Mutant Leu300Pro-Fidarestat Complex J.Med.Chem., 48:5659-5665, 2005 Cited by PubMed: 16134934 DOI: 10.1021/jm050424+ PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1 Å)

Structure validation