2AGT

Aldose Reductase Mutant Leu 300 Pro complexed with Fidarestat

Summary for 2AGT

Related1PWM
DescriptorAldose reductase, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
Functional Keywordsoxidoreductase, nadp, fidarestat
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P15121
Total number of polymer chains1
Total molecular weight37414.78
Authors
Petrova, T.,Steuber, H.,Hazemann, I.,Cousido-Siah, A.,Mitschler, A.,Chung, R.,Oka, M.,Klebe, G.,El-Kabbani, O.,Joachimiak, A.,Podjarny, A. (deposition date: 2005-07-27, release date: 2005-09-20, Last modification date: 2011-07-13)
Primary citation
Petrova, T.,Steuber, H.,Hazemann, I.,Cousido-Siah, A.,Mitschler, A.,Chung, R.,Oka, M.,Klebe, G.,El-Kabbani, O.,Joachimiak, A.,Podjarny, A.
Factorizing Selectivity Determinants of Inhibitor Binding toward Aldose and Aldehyde Reductases: Structural and Thermodynamic Properties of the Aldose Reductase Mutant Leu300Pro-Fidarestat Complex
J.Med.Chem., 48:5659-5665, 2005
PubMed: 16134934 (PDB entries with the same primary citation)
DOI: 10.1021/jm050424+
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.11480.6%2.8%2.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report