1PWM
Crystal structure of human Aldose Reductase complexed with NADP and Fidarestat
Summary for 1PWM
Entry DOI | 10.2210/pdb1pwm/pdb |
Related | 1PWL |
Descriptor | aldose reductase, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | aldose reductase, atomic resolution, ternary complex, inhibitor binding, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 36956.42 |
Authors | El-Kabbani, O.,Darmanin, C.,Schneider, T.R.,Hazemann, I.,Ruiz, F.,Oka, M.,Joachimiak, A.,Schulze-Briese, C.,Tomizaki, T.,Mitschler, A.,Podjarny, A. (deposition date: 2003-07-02, release date: 2004-02-24, Last modification date: 2024-04-03) |
Primary citation | El-Kabbani, O.,Darmanin, C.,Schneider, T.R.,Hazemann, I.,Ruiz, F.,Oka, M.,Joachimiak, A.,Schulze-Briese, C.,Tomizaki, T.,Mitschler, A.,Podjarny, A. Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors PROTEINS, 55:805-813, 2004 Cited by PubMed: 15146479DOI: 10.1002/prot.20001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (0.92 Å) |
Structure validation
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