2AGT
Aldose Reductase Mutant Leu 300 Pro complexed with Fidarestat
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Aldose reductase | polymer | 319 | 36164.6 | 1 | UniProt (P15121) Pfam (PF00248) In PDB | Homo sapiens (human) | AR, Aldehyde reductase |
| 2 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 3 | A | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 4 | A | (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE | non-polymer | 279.2 | 1 | Chemie (FID) | |||
| 5 | A | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 6 | water | water | 18.0 | 585 | Chemie (HOH) |
Sequence modifications
A: 0 - 315 (UniProt: P15121)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | cloning artifact |
| Ser -2 | - | cloning artifact |
| His -1 | - | cloning artifact |
| Pro 300 | Leu 301 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36164.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1250.2 | |
| All* | Total formula weight | 37414.8 |
