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2AGT

Aldose Reductase Mutant Leu 300 Pro complexed with Fidarestat

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AAldose reductasepolymer31936164.61UniProt (P15121)
Pfam (PF00248)
In PDB
Homo sapiens (human)AR, Aldehyde reductase
2ACHLORIDE IONnon-polymer35.51Chemie (CL)
3ANADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATEnon-polymer743.41Chemie (NAP)
4A(2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONEnon-polymer279.21Chemie (FID)
5ACITRIC ACIDnon-polymer192.11Chemie (CIT)
6waterwater18.0585Chemie (HOH)
Sequence modifications
A: 0 - 315 (UniProt: P15121)
PDBExternal DatabaseDetails
Gly -3-cloning artifact
Ser -2-cloning artifact
His -1-cloning artifact
Pro 300Leu 301engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight36164.6
Non-Polymers*Number of molecules4
Total formula weight1250.2
All*Total formula weight37414.8
*Water molecules are not included.

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PDB entries from 2024-09-18

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