6B9O

Structure of GH 38 Jack Bean alpha-mannosidase

Summary for 6B9O

• Entry DOI: 10.2210/pdb6b9o/pdb
• Descriptor: Alpha-mannosidase from Canavalia ensiformis (jack bean), alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: mannosidase, plant protein, hydrolase
• Biological source: Canavalia ensiformis
• Total number of polymer chains: 2
• Total formula weight: 227554.46

Authors

Howard, E.,Cousido-Siah, A.,Lepage, M.,Bodlenner, A.,Mitschler, A.,Meli, A.,De Riccardis, F.,Izzo, I.,Podjarny, A.,Compain, P. (deposition date: 2017-10-11, release date: 2018-09-26, Last modification date: 2023-10-04)

• Primary citation: Howard, E.,Cousido-Siah, A.,Lepage, M.L.,Schneider, J.P.,Bodlenner, A.,Mitschler, A.,Meli, A.,Izzo, I.,Alvarez, H.A.,Podjarny, A.,Compain, P.; Structural Basis of Outstanding Multivalent Effects in Jack Bean alpha-Mannosidase Inhibition.; Angew. Chem. Int. Ed. Engl., 57:8002-8006, 2018; PubMed: 29722924; DOI: 10.1002/anie.201801202

Experimental method

X-RAY DIFFRACTION (1.841 Å)