6B9P
Structure of GH 38 Jack Bean alpha-mannosidase in complex with a 36-valent iminosugar cluster inhibitor
Summary for 6B9P
Entry DOI | 10.2210/pdb6b9p/pdb |
Descriptor | Alpha-mannosidase from Canavalia ensiformis (jack bean), alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | mannosidase, plant protein, hydrolase |
Biological source | Canavalia ensiformis |
Total number of polymer chains | 2 |
Total formula weight | 228323.48 |
Authors | Howard, E.,Cousido-Siah, A.,Lepage, M.,Bodlenner, A.,Mitschler, A.,Meli, A.,De Riccardis, F.,Izzo, I.,Podjarny, A.,Compain, P. (deposition date: 2017-10-11, release date: 2018-09-26, Last modification date: 2023-10-04) |
Primary citation | Howard, E.,Cousido-Siah, A.,Lepage, M.L.,Schneider, J.P.,Bodlenner, A.,Mitschler, A.,Meli, A.,Izzo, I.,Alvarez, H.A.,Podjarny, A.,Compain, P. Structural Basis of Outstanding Multivalent Effects in Jack Bean alpha-Mannosidase Inhibition. Angew. Chem. Int. Ed. Engl., 57:8002-8006, 2018 Cited by PubMed: 29722924DOI: 10.1002/anie.201801202 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.996 Å) |
Structure validation
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