5M2F

Crystal structure of human AKR1B10 complexed with NADP+ and the synthetic retinoid UVI2008

Summary for 5M2F

• Entry DOI: 10.2210/pdb5m2f/pdb
• Related: 1ZUA
• Descriptor: Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-bromo-4-[(1E)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl]benzoic acid, ... (5 entities in total)
• Functional Keywords: tim barrel, aldo-keto reductase, oxidoreductase, synthetic retinoid, cytosolic
• Biological source: Homo sapiens (Human)
• Cellular location: Lysosome : O60218
• Total number of polymer chains: 1
• Total formula weight: 37679.97

Authors

Ruiz, F.X.,Cousido-Siah, A.,Mitschler, A.,Porte, S.,Alvarez, S.,Dominguez, M.,Alvarez, R.,de Lera, A.R.,Pares, X.,Farres, J.,Podjarny, A. (deposition date: 2016-10-12, release date: 2017-02-15, Last modification date: 2024-01-17)

• Primary citation: Ruiz, F.X.,Crespo, I.,Alvarez, S.,Porte, S.,Gimenez-Dejoz, J.,Cousido-Siah, A.,Mitschler, A.,de Lera, A.R.,Pares, X.,Podjarny, A.,Farres, J.; Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008.; Chem. Biol. Interact., 276:174-181, 2017; PubMed: 28161411; DOI: 10.1016/j.cbi.2017.01.026

Experimental method

X-RAY DIFFRACTION (1.503 Å)