5M2F
Crystal structure of human AKR1B10 complexed with NADP+ and the synthetic retinoid UVI2008
Functional Information from GO Data
Chain | GOid | namespace | contents |
X | 0001523 | biological_process | retinoid metabolic process |
X | 0001758 | molecular_function | retinal dehydrogenase activity |
X | 0004032 | molecular_function | aldose reductase (NADPH) activity |
X | 0004033 | molecular_function | aldo-keto reductase (NADPH) activity |
X | 0005515 | molecular_function | protein binding |
X | 0005576 | cellular_component | extracellular region |
X | 0005764 | cellular_component | lysosome |
X | 0005829 | cellular_component | cytosol |
X | 0006629 | biological_process | lipid metabolic process |
X | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
X | 0016488 | biological_process | farnesol catabolic process |
X | 0016491 | molecular_function | oxidoreductase activity |
X | 0042572 | biological_process | retinol metabolic process |
X | 0044597 | biological_process | daunorubicin metabolic process |
X | 0044598 | biological_process | doxorubicin metabolic process |
X | 0045550 | molecular_function | geranylgeranyl reductase activity |
X | 0047655 | molecular_function | allyl-alcohol dehydrogenase activity |
X | 0047718 | molecular_function | indanol dehydrogenase activity |
X | 0052650 | molecular_function | all-trans-retinol dehydrogenase (NADP+) activity |
X | 0110095 | biological_process | cellular detoxification of aldehyde |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 35 |
Details | binding site for residue NAP X 401 |
Chain | Residue |
X | GLY19 |
X | GLN184 |
X | TYR210 |
X | SER211 |
X | PRO212 |
X | LEU213 |
X | GLY214 |
X | SER215 |
X | PRO216 |
X | ASP217 |
X | ALA246 |
X | THR20 |
X | ILE261 |
X | PRO262 |
X | MLY263 |
X | SER264 |
X | VAL265 |
X | THR266 |
X | ARG269 |
X | GLU272 |
X | ASN273 |
X | UV8402 |
X | TRP21 |
X | HOH508 |
X | HOH523 |
X | HOH529 |
X | HOH535 |
X | HOH561 |
X | HOH587 |
X | ASP44 |
X | TYR49 |
X | LYS78 |
X | HIS111 |
X | SER160 |
X | ASN161 |
site_id | AC2 |
Number of Residues | 12 |
Details | binding site for residue UV8 X 402 |
Chain | Residue |
X | TRP21 |
X | TYR49 |
X | TRP80 |
X | HIS111 |
X | PHE123 |
X | PRO124 |
X | ARG125 |
X | GLY129 |
X | ALA131 |
X | LEU301 |
X | LEU302 |
X | NAP401 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue EDO X 403 |
Chain | Residue |
X | GLU6 |
X | HIS201 |
X | GLY204 |
X | ASN257 |
X | HOH563 |
Functional Information from PROSITE/UniProt
site_id | PS00062 |
Number of Residues | 18 |
Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MeelvdeglVKALGVSNF |
Chain | Residue | Details |
X | MET145-PHE162 |
site_id | PS00063 |
Number of Residues | 16 |
Details | ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. IPKSVTpaRIvENiQV |
Chain | Residue | Details |
X | ILE261-VAL276 |
site_id | PS00798 |
Number of Residues | 18 |
Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHIDCAyvyqnEheVG |
Chain | Residue | Details |
X | GLY39-GLY56 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton donor => ECO:0000269|PubMed:18087047 |
Chain | Residue | Details |
X | TYR49 |
site_id | SWS_FT_FI2 |
Number of Residues | 7 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18087047 |
Chain | Residue | Details |
X | THR20 | |
X | ASP44 | |
X | HIS111 | |
X | SER160 | |
X | GLN184 | |
X | TYR210 | |
X | ILE261 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | SITE: Lowers pKa of active site Tyr => ECO:0000250|UniProtKB:P14550 |
Chain | Residue | Details |
X | LYS78 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
X | ARG125 | |
X | MLY263 |