1EL3
HUMAN ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR
Summary for 1EL3
Entry DOI | 10.2210/pdb1el3/pdb |
Descriptor | ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [2,6-DIMETHYL-4-(2-O-TOLYL-ACETYLAMINO)-BENZENESULFONYL]-GLYCINE, ... (4 entities in total) |
Functional Keywords | aldose reductase, inhibition, diabetes, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 37032.20 |
Authors | Podjarny, A. (deposition date: 2000-03-13, release date: 2000-05-10, Last modification date: 2024-04-03) |
Primary citation | Calderone, V.,Chevrier, B.,Van Zandt, M.,Lamour, V.,Howard, E.,Poterszman, A.,Barth, P.,Mitschler, A.,Lu, J.,Dvornik, D.M.,Klebe, G.,Kraemer, O.,Moorman, A.R.,Moras, D.,Podjarny, A. The structure of human aldose reductase bound to the inhibitor IDD384. Acta Crystallogr.,Sect.D, 56:536-540, 2000 Cited by PubMed: 10771421DOI: 10.1107/S0907444900002341 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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