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1BX4
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STRUCTURE OF HUMAN ADENOSINE KINASE AT 1.50 ANGSTROMS
Descriptor:PROTEIN (ADENOSINE KINASE), CHLORIDE ION, MAGNESIUM ION, ...
Authors:Mathews, I.I., Erion, M.D., Ealick, S.E.
Deposit date:1998-10-13
Release date:1999-10-13
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of human adenosine kinase at 1.5 A resolution.
Biochemistry, 37, 1998
1D7A
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CRYSTAL STRUCTURE OF E. COLI PURE-MONONUCLEOTIDE COMPLEX.
Descriptor:PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE, 5-AMINOIMIDAZOLE RIBONUCLEOTIDE
Authors:Mathews, I.I., Kappock, T.J., Stubbe, J., Ealick, S.E.
Deposit date:1999-10-16
Release date:1999-12-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway.
Structure Fold.Des., 7, 1999
1O24
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE COMPLEMENTING PROTEIN (TM0449) FROM THERMOTOGA MARITIMA AT 2.0 A RESOLUTION
Descriptor:Thymidylate synthase thyX
Authors:Mathews, I.I., Deacon, A.M., Canaves, J.M., McMullan, D., Lesley, S.A., Agarwalla, S., Kuhn, P., Joint Center for Structural Genomics (JCSG)
Deposit date:2003-02-18
Release date:2003-06-24
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O25
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE COMPLEMENTING PROTEIN (TM0449) FROM THERMOTOGA MARITIMA WITH DUMP AT 2.4 A RESOLUTION
Descriptor:Thymidylate synthase thyX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Mathews, I.I., Deacon, A.M., Canaves, J.M., McMullan, D., Lesley, S.A., Agarwalla, S., Kuhn, P., Joint Center for Structural Genomics (JCSG)
Deposit date:2003-02-20
Release date:2003-06-24
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O26
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE COMPLEMENTING PROTEIN (TM0449) FROM THERMOTOGA MARITIMA WITH FAD AND DUMP AT 1.6 A RESOLUTION
Descriptor:Thymidylate synthase thyX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Mathews, I.I., Deacon, A.M., Canaves, J.M., McMullan, D., Lesley, S.A., Agarwalla, S., Kuhn, P., Joint Center for Structural Genomics (JCSG)
Deposit date:2003-02-18
Release date:2003-06-24
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O27
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE COMPLEMENTING PROTEIN (TM0449) FROM THERMOTOGA MARITIMA WITH FAD AND BRDUMP AT 2.3 A RESOLUTION
Descriptor:Thymidylate synthase thyX, 5-BROMO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Mathews, I.I., Deacon, A.M., Canaves, J.M., McMullan, D., Lesley, S.A., Agarwalla, S., Kuhn, P., Joint Center for Structural Genomics (JCSG)
Deposit date:2003-02-18
Release date:2003-06-24
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O28
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE COMPLEMENTING PROTEIN (TM0449) FROM THERMOTOGA MARITIMA WITH FDUMP AT 2.1 A RESOLUTION
Descriptor:Thymidylate synthase thyX, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Mathews, I.I., Deacon, A.M., Canaves, J.M., McMullan, D., Lesley, S.A., Agarwalla, S., Kuhn, P., Joint Center for Structural Genomics (JCSG)
Deposit date:2003-02-18
Release date:2003-06-24
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O29
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE COMPLEMENTING PROTEIN (TM0449) FROM THERMOTOGA MARITIMA WITH FAD AND FDUMP AT 2.0 A RESOLUTION
Descriptor:Thymidylate synthase thyX, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Mathews, I.I., Deacon, A.M., Canaves, J.M., McMullan, D., Lesley, S.A., Agarwalla, S., Kuhn, P., Joint Center for Structural Genomics (JCSG)
Deposit date:2003-02-18
Release date:2003-06-24
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O2A
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE COMPLEMENTING PROTEIN (TM0449) FROM THERMOTOGA MARITIMA WITH FAD AT 1.8 A RESOLUTION
Descriptor:Thymidylate synthase thyX, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Mathews, I.I., Deacon, A.M., Canaves, J.M., McMullan, D., Lesley, S.A., Agarwalla, S., Kuhn, P., Joint Center for Structural Genomics (JCSG)
Deposit date:2003-02-18
Release date:2003-06-24
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O2B
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE COMPLEMENTING PROTEIN (TM0449) FROM THERMOTOGA MARITIMA WITH FAD AND PO4 AT 2.45 A RESOLUTION
Descriptor:Thymidylate synthase thyX, PHOSPHATE ION, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Mathews, I.I., Deacon, A.M., Canaves, J.M., McMullan, D., Lesley, S.A., Agarwalla, S., Kuhn, P., Joint Center for Structural Genomics (JCSG)
Deposit date:2003-02-18
Release date:2003-06-24
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
4KAR
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CRYSTAL STRUCTURE OF FDTS (TM0449) MUTANT (H53D) WITH FAD
Descriptor:Thymidylate synthase, FLAVIN-ADENINE DINUCLEOTIDE, NONAETHYLENE GLYCOL
Authors:Mathews, I.I.
Deposit date:2013-04-22
Release date:2014-03-26
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Flavin-Dependent Thymidylate Synthase as a Drug Target for Deadly Microbes: Mutational Study and a Strategy for Inhibitor Design.
J Bioterror Biodef, Suppl 12, 2013
4KAS
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CRYSTAL STRUCTURE OF FDTS FROM T. MARITIMA MUTANT (H53D) WITH FAD AND DUMP
Descriptor:Thymidylate synthase ThyX, 2'-DEOXYURIDINE-5'-MONOPHOSPHATE, SULFATE ION, ...
Authors:Mathews, I.I.
Deposit date:2013-04-22
Release date:2014-03-26
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Flavin-Dependent Thymidylate Synthase as a Drug Target for Deadly Microbes: Mutational Study and a Strategy for Inhibitor Design.
J Bioterror Biodef, Suppl 12, 2013
4KAT
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CRYSTAL STRUCTURE OF FDTS FROM T. MARITIMA MUTANT (R174K) WITH FAD AND DUMP
Descriptor:Thymidylate synthase, 2'-DEOXYURIDINE-5'-MONOPHOSPHATE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE
Authors:Mathews, I.I.
Deposit date:2013-04-22
Release date:2014-03-26
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Flavin-Dependent Thymidylate Synthase as a Drug Target for Deadly Microbes: Mutational Study and a Strategy for Inhibitor Design.
J Bioterror Biodef, Suppl 12, 2013
6APF
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TRANS-ACTING TRANSFERASE FROM DISORAZOLE SYNTHASE COMPLEXED WITH CITRATE.
Descriptor:DisD protein, CITRIC ACID, GLYCEROL, ...
Authors:Mathews, I.I., Lyubimov, A., Soltis, M., Khosla, C., Cohen, A., Robbins, T.
Deposit date:2017-08-17
Release date:2018-04-04
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography.
Biochemistry, 56, 2017
6APG
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TRANS-ACTING TRANSFERASE FROM DISORAZOLE SYNTHASE WITH MALONATE
Descriptor:DisD protein, MALONATE ION, GLYCEROL, ...
Authors:Mathews, I.I., Lyubimov, A.Y., Soltis, S.M., Khosla, C., Robbins, T., Cohen, A.E.
Deposit date:2017-08-17
Release date:2018-04-04
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography.
Biochemistry, 56, 2017
3G4A
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CRYSTAL STRUCTURE OF FLAVINE DEPENDANT THYMIDYLATE SYNTHASE S88A MUTANT FROM THERMOTOGA MARITIMA AT 1.95 ANGSTROM RESOLUTION
Descriptor:Thymidylate synthase thyX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Mathews, I.I., Lesley, S.A., Kohen, A.
Deposit date:2009-02-03
Release date:2009-04-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.
Nature, 458, 2009
3G4C
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FLAVINE DEPENDANT THYMIDYLATE SYNTAHSE S88C MUTANT
Descriptor:Thymidylate synthase thyX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Mathews, I.I., Lesley, S.A., Kohen, A.
Deposit date:2009-02-03
Release date:2009-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.
Nature, 458, 2009
3N0B
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TM0449 MUTANT CRYSTALS GROWN IN LOOPS/MICROMOUNTS
Descriptor:Thymidylate synthase thyX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Mathews, I.I.
Deposit date:2010-05-13
Release date:2011-05-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Diffraction study of protein crystals grown in cryoloops and micromounts.
J.Appl.Crystallogr., 43, 2010
3N0C
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TM0449 MUTANT CRYSTAL GROWN BY HANGING DROP METHOD
Descriptor:Thymidylate synthase thyX, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Mathews, I.I.
Deposit date:2010-05-13
Release date:2011-05-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Diffraction study of protein crystals grown in cryoloops and micromounts.
J.Appl.Crystallogr., 43, 2010
1CEA
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THE STRUCTURE OF THE NON-COVALENT COMPLEX OF RECOMBINANT KRINGLE 1 DOMAIN OF HUMAN PLASMINOGEN WITH EACA (EPSILON-AMINOCAPROIC ACID)
Descriptor:PLASMINOGEN, 6-AMINOHEXANOIC ACID
Authors:Tulinsky, A., Mathews, I.I.
Deposit date:1995-12-03
Release date:1996-04-03
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid.
Biochemistry, 35, 1996
1CEB
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THE STRUCTURE OF THE NON-COVALENT COMPLEX OF RECOMBINANT KRINGLE 1 DOMAIN OF HUMAN PLASMINOGEN WITH AMCHA (TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID)
Descriptor:PLASMINOGEN, TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID
Authors:Tulinsky, A., Mathews, I.I.
Deposit date:1995-12-03
Release date:1996-04-03
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid.
Biochemistry, 35, 1996
1FPC
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ACTIVE SITE MIMETIC INHIBITION OF THROMBIN
Descriptor:thrombin, Hirudin, amino{[(4S)-4-({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)-5-(4-ethylpiperidin-1-yl)-5-oxopentyl]amino}methaniminium
Authors:Tulinsky, A., Mathews, I.I.
Deposit date:1994-10-16
Release date:1995-02-27
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Active-site mimetic inhibition of thrombin.
Acta Crystallogr.,Sect.D, 51, 1995
1HLT
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THE STRUCTURE OF A NONADECAPEPTIDE OF THE FIFTH EGF DOMAIN OF THROMBOMODULIN COMPLEXED WITH THROMBIN
Descriptor:ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), Thrombomodulin, ...
Authors:Tulinsky, A., Mathews, I.I.
Deposit date:1994-08-28
Release date:1994-12-20
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin.
Biochemistry, 33, 1994
1NRN
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CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES
Descriptor:ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), RECEPTOR BASED PEPTIDE NRS
Authors:Tulinsky, A., Mathews, I.I.
Deposit date:1994-01-18
Release date:1994-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.
Biochemistry, 33, 1994
1NRO
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CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES
Descriptor:ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), RECEPTOR BASED PEPTIDE NRP
Authors:Tulinsky, A., Mathews, I.I.
Deposit date:1994-01-18
Release date:1994-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.
Biochemistry, 33, 1994