4KAT

Crystal structure of FDTS from T. maritima mutant (R174K) with FAD and dUMP

Summary for 4KAT

Entry DOI	10.2210/pdb4kat/pdb
Related	4KAR 4KAS
Descriptor	Thymidylate synthase, 2'-DEOXYURIDINE-5'-MONOPHOSPHATE, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ... (4 entities in total)
Functional Keywords	thyx, fdts, fad, dump, novel fdts fold, convertion of dump to dtmp using tetrahydrofolate, transferase
Biological source	Thermotoga maritima MSB8
Total number of polymer chains	4
Total formula weight	114285.66
Authors	Mathews, I.I. (deposition date: 2013-04-22, release date: 2014-03-26, Last modification date: 2023-09-20)
Primary citation	Mathews, I.I. Flavin-Dependent Thymidylate Synthase as a Drug Target for Deadly Microbes: Mutational Study and a Strategy for Inhibitor Design. J Bioterror Biodef, Suppl 12:004-004, 2013 Cited by PubMed: 24563811 DOI: 10.4172/2157-2526.S12-004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.14 Å)

Structure validation