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4KAR

Crystal structure of FDTS (TM0449) mutant (H53D) with FAD

Summary for 4KAR
Entry DOI10.2210/pdb4kar/pdb
Related4KAS 4KAT
DescriptorThymidylate synthase, FLAVIN-ADENINE DINUCLEOTIDE, NONAETHYLENE GLYCOL, ... (4 entities in total)
Functional Keywordsthyx, fdts, h53d mutant, fad, novel fdts fold, convertion of dump to dtmp using tetrahydrofolate, and nad(p)h, transferase
Biological sourceThermotoga maritima MSB8
Total number of polymer chains4
Total formula weight113479.17
Authors
Mathews, I.I. (deposition date: 2013-04-22, release date: 2014-03-26, Last modification date: 2023-09-20)
Primary citationMathews, I.I.
Flavin-Dependent Thymidylate Synthase as a Drug Target for Deadly Microbes: Mutational Study and a Strategy for Inhibitor Design.
J Bioterror Biodef, Suppl 12:004-004, 2013
Cited by
PubMed: 24563811
DOI: 10.4172/2157-2526.S12-004
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.03 Å)
Structure validation

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