4KAS

Crystal structure of FDTS from T. maritima mutant (H53D) with FAD and dUMP

Summary for 4KAS

Entry DOI	10.2210/pdb4kas/pdb
Related	4KAR 4KAT
Descriptor	Thymidylate synthase ThyX, 2'-DEOXYURIDINE-5'-MONOPHOSPHATE, SULFATE ION, ... (8 entities in total)
Functional Keywords	thyx, fdts, fad, dump, novel fdts fold, convertion of dump to dtmp using tetrahydrofolate, and nad(p)hc, transferase
Biological source	Thermotoga maritima
Total number of polymer chains	4
Total formula weight	113155.17
Authors	Mathews, I.I. (deposition date: 2013-04-22, release date: 2014-03-26, Last modification date: 2023-09-20)
Primary citation	Mathews, I.I. Flavin-Dependent Thymidylate Synthase as a Drug Target for Deadly Microbes: Mutational Study and a Strategy for Inhibitor Design. J Bioterror Biodef, Suppl 12:004-004, 2013 Cited by PubMed: 24563811 DOI: 10.4172/2157-2526.S12-004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation