4KAS
Crystal structure of FDTS from T. maritima mutant (H53D) with FAD and dUMP
Summary for 4KAS
Entry DOI | 10.2210/pdb4kas/pdb |
Related | 4KAR 4KAT |
Descriptor | Thymidylate synthase ThyX, 2'-DEOXYURIDINE-5'-MONOPHOSPHATE, SULFATE ION, ... (8 entities in total) |
Functional Keywords | thyx, fdts, fad, dump, novel fdts fold, convertion of dump to dtmp using tetrahydrofolate, and nad(p)hc, transferase |
Biological source | Thermotoga maritima |
Total number of polymer chains | 4 |
Total formula weight | 113155.17 |
Authors | Mathews, I.I. (deposition date: 2013-04-22, release date: 2014-03-26, Last modification date: 2023-09-20) |
Primary citation | Mathews, I.I. Flavin-Dependent Thymidylate Synthase as a Drug Target for Deadly Microbes: Mutational Study and a Strategy for Inhibitor Design. J Bioterror Biodef, Suppl 12:004-004, 2013 Cited by PubMed: 24563811DOI: 10.4172/2157-2526.S12-004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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