4KAS
Crystal structure of FDTS from T. maritima mutant (H53D) with FAD and dUMP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Thymidylate synthase ThyX | polymer | 232 | 27480.6 | 4 | UniProt (Q9WYT0) Pfam (PF02511) In PDB | Thermotoga maritima | TS, TSase |
2 | A, B, C | 2'-DEOXYURIDINE-5'-MONOPHOSPHATE | non-polymer | 308.2 | 3 | Chemie (DU) | |||
3 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
4 | C, D | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 2 | Chemie (FAD) | |||
5 | C | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
6 | D | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
7 | D | NONAETHYLENE GLYCOL | non-polymer | 414.5 | 1 | Chemie (2PE) | |||
8 | water | water | 18.0 | 305 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 220 (UniProt: Q9WYT0)
PDB | External Database | Details |
---|---|---|
Met -11 | - | initiating methionine |
Gly -10 | - | expression tag |
Ser -9 | - | expression tag |
Asp -8 | - | expression tag |
Lys -7 | - | expression tag |
Ile -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
Asp 53 | His 53 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 109922.5 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 3232.7 | |
All* | Total formula weight | 113155.2 |