Author results

1IR3
  • Download 1ir3
  • View 1ir3
Molmil generated image of 1ir3
PHOSPHORYLATED INSULIN RECEPTOR TYROSINE KINASE IN COMPLEX WITH PEPTIDE SUBSTRATE AND ATP ANALOG
Descriptor:INSULIN RECEPTOR, PEPTIDE SUBSTRATE, MAGNESIUM ION, ...
Authors:Hubbard, S.R.
Deposit date:1997-09-22
Release date:1998-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog.
EMBO J., 16, 1997
1IRK
  • Download 1irk
  • View 1irk
Molmil generated image of 1irk
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR
Descriptor:INSULIN RECEPTOR TYROSINE KINASE DOMAIN, ETHYL MERCURY ION
Authors:Hubbard, S.R., Wei, L., Ellis, L., Hendrickson, W.A.
Deposit date:1995-01-02
Release date:1995-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the tyrosine kinase domain of the human insulin receptor.
Nature, 372, 1994
3RGK
  • Download 3rgk
  • View 3rgk
Molmil generated image of 3rgk
CRYSTAL STRUCTURE OF HUMAN MYOGLOBIN MUTANT K45R
Descriptor:Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
Authors:Hubbard, S.R.
Deposit date:2011-04-08
Release date:2011-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:X-ray crystal structure of a recombinant human myoglobin mutant at 2.8 A resolution
J.Mol.Biol., 20, 1990
3HK0
  • Download 3hk0
  • View 3hk0
Molmil generated image of 3hk0
CRYSTAL STRUCTURE OF THE RA AND PH DOMAINS OF GRB10
Descriptor:Growth factor receptor-bound protein 10, THIOCYANATE ION
Authors:Hubbard, S.R., Depetris, R.S., Wu, J.
Deposit date:2009-05-22
Release date:2009-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.
Nat.Struct.Mol.Biol., 16, 2009
4XLV
  • Download 4xlv
  • View 4xlv
Molmil generated image of 4xlv
CRYSTAL STRUCTURE OF THE ACTIVATED INSULIN RECEPTOR TYROSINE KINASE DIMER
Descriptor:Insulin receptor, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, MAGNESIUM ION
Authors:Hubbard, S.R., Li, S.
Deposit date:2015-01-13
Release date:2015-03-25
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The insulin and IGF1 receptor kinase domains are functional dimers in the activated state.
Nat Commun, 6, 2015
6D42
  • Download 6d42
  • View 6d42
Molmil generated image of 6d42
CRYSTAL STRUCTURE OF THE KCA3.1 C-TERMINAL FOUR-HELIX BUNDLE (WITH COPPER)
Descriptor:Intermediate conductance calcium-activated potassium channel protein 4, COPPER (II) ION
Authors:Hubbard, S.R., Ji, T.
Deposit date:2018-04-17
Release date:2018-07-11
Method:X-RAY DIFFRACTION (1.750136 Å)
Cite:Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1.
PLoS ONE, 13, 2018
1AGW
  • Download 1agw
  • View 1agw
Molmil generated image of 1agw
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU4984 INHIBITOR
Descriptor:FGF RECEPTOR 1, 3-[4-(1-FORMYLPIPERAZIN-4-YL)-BENZYLIDENYL]-2-INDOLINONE
Authors:Mohammadi, M., Schlessinger, J., Hubbard, S.R.
Deposit date:1997-03-25
Release date:1998-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
Science, 276, 1997
1FGI
  • Download 1fgi
  • View 1fgi
Molmil generated image of 1fgi
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU5402 INHIBITOR
Descriptor:FGF RECEPTOR 1, 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE
Authors:Mohammadi, M., Schlessinger, J., Hubbard, S.R.
Deposit date:1997-03-22
Release date:1998-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
Science, 276, 1997
1GAG
  • Download 1gag
  • View 1gag
Molmil generated image of 1gag
CRYSTAL STRUCTURE OF THE INSULIN RECEPTOR KINASE IN COMPLEX WITH A BISUBSTRATE INHIBITOR
Descriptor:INSULIN RECEPTOR, TYROSINE KINASE DOMAIN, BISUBSTRATE PEPTIDE INHIBITOR, ...
Authors:Parang, K., Till, J.H., Ablooglu, A.J., Kohanski, R.A., Hubbard, S.R., Cole, P.A.
Deposit date:2000-11-29
Release date:2001-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism-based design of a protein kinase inhibitor.
Nat.Struct.Biol., 8, 2001
1CVS
  • Download 1cvs
  • View 1cvs
Molmil generated image of 1cvs
CRYSTAL STRUCTURE OF A DIMERIC FGF2-FGFR1 COMPLEX
Descriptor:FIBROBLAST GROWTH FACTOR 2, FIBROBLAST GROWTH FACTOR RECEPTOR 1, SULFATE ION
Authors:Plotnikov, A.N., Schlessinger, J., Hubbard, S.R., Mohammadi, M.
Deposit date:1999-08-24
Release date:2000-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for FGF receptor dimerization and activation.
Cell(Cambridge,Mass.), 98, 1999
1DCQ
  • Download 1dcq
  • View 1dcq
Molmil generated image of 1dcq
CRYSTAL STRUCTURE OF THE ARF-GAP DOMAIN AND ANKYRIN REPEATS OF PAPBETA.
Descriptor:PYK2-ASSOCIATED PROTEIN BETA, ZINC ION
Authors:Mandiyan, V., Andreev, J., Schlessinger, J., Hubbard, S.R.
Deposit date:1999-11-05
Release date:1999-12-22
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the ARF-GAP domain and ankyrin repeats of PYK2-associated protein beta.
EMBO J., 18, 1999
1EV2
  • Download 1ev2
  • View 1ev2
Molmil generated image of 1ev2
CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)
Descriptor:PROTEIN (FIBROBLAST GROWTH FACTOR 2), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 2), SULFATE ION
Authors:Plotnikov, A.N., Hubbard, S.R., Schlessinger, J., Mohammadi, M.
Deposit date:2000-04-19
Release date:2000-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Cell(Cambridge,Mass.), 101, 2000
1EVT
  • Download 1evt
  • View 1evt
Molmil generated image of 1evt
CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1)
Descriptor:PROTEIN (FIBROBLAST GROWTH FACTOR 1), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 1), SULFATE ION
Authors:Plotnikov, A.N., Hubbard, S.R., Schlessinger, J., Mohammadi, M.
Deposit date:2000-04-20
Release date:2000-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Cell(Cambridge,Mass.), 101, 2000
1FGK
  • Download 1fgk
  • View 1fgk
Molmil generated image of 1fgk
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1
Descriptor:FGF RECEPTOR 1
Authors:Mohammadi, M., Schlessinger, J., Hubbard, S.R.
Deposit date:1997-02-08
Release date:1997-07-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism.
Cell(Cambridge,Mass.), 86, 1996
1I44
  • Download 1i44
  • View 1i44
Molmil generated image of 1i44
CRYSTALLOGRAPHIC STUDIES OF AN ACTIVATION LOOP MUTANT OF THE INSULIN RECEPTOR TYROSINE KINASE
Descriptor:INSULIN RECEPTOR, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Till, J.H., Ablooglu, A.J., Frankel, M., Kohanski, R.A., Hubbard, S.R.
Deposit date:2001-02-19
Release date:2001-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism.
J.Biol.Chem., 276, 2001
1K3A
  • Download 1k3a
  • View 1k3a
Molmil generated image of 1k3a
STRUCTURE OF THE INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR KINASE
Descriptor:insulin-like growth factor 1 receptor, insulin receptor substrate 1, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Favelyukis, S., Till, J.H., Hubbard, S.R., Miller, W.T.
Deposit date:2001-10-02
Release date:2001-11-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and autoregulation of the insulin-like growth factor 1 receptor kinase.
Nat.Struct.Biol., 8, 2001
1LUF
  • Download 1luf
  • View 1luf
Molmil generated image of 1luf
CRYSTAL STRUCTURE OF THE MUSK TYROSINE KINASE: INSIGHTS INTO RECEPTOR AUTOREGULATION
Descriptor:muscle-specific tyrosine kinase receptor musk
Authors:Till, J.H., Becerra, M., Watty, A., Lu, Y., Ma, Y., Neubert, T.A., Burden, S.J., Hubbard, S.R.
Deposit date:2002-05-22
Release date:2002-09-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation.
Structure, 10, 2002
1NRV
  • Download 1nrv
  • View 1nrv
Molmil generated image of 1nrv
CRYSTAL STRUCTURE OF THE SH2 DOMAIN OF GRB10
Descriptor:Growth factor receptor-bound protein 10
Authors:Stein, E.G., Hubbard, S.R.
Deposit date:2003-01-25
Release date:2003-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity.
J.Biol.Chem., 278, 2003
1P14
  • Download 1p14
  • View 1p14
Molmil generated image of 1p14
CRYSTAL STRUCTURE OF A CATALYTIC-LOOP MUTANT OF THE INSULIN RECEPTOR TYROSINE KINASE
Descriptor:insulin receptor
Authors:Li, S., Covino, N.D., Stein, E.G., Till, J.H., Hubbard, S.R.
Deposit date:2003-04-11
Release date:2003-07-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor
J.Biol.Chem., 278, 2003
1RPY
  • Download 1rpy
  • View 1rpy
Molmil generated image of 1rpy
CRYSTAL STRUCTURE OF THE DIMERIC SH2 DOMAIN OF APS
Descriptor:adaptor protein APS, SULFATE ION
Authors:Hu, J., Liu, J., Ghirlando, R., Saltiel, A.R., Hubbard, S.R.
Deposit date:2003-12-03
Release date:2003-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor.
Mol.Cell, 12, 2003
1RQQ
  • Download 1rqq
  • View 1rqq
Molmil generated image of 1rqq
CRYSTAL STRUCTURE OF THE INSULIN RECEPTOR KINASE IN COMPLEX WITH THE SH2 DOMAIN OF APS
Descriptor:Insulin receptor, adaptor protein APS, BISUBSTRATE INHIBITOR, ...
Authors:Hu, J., Liu, J., Ghirlando, R., Saltiel, A.R., Hubbard, S.R.
Deposit date:2003-12-06
Release date:2003-12-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor.
Mol.Cell, 12, 2003
1YVH
  • Download 1yvh
  • View 1yvh
Molmil generated image of 1yvh
CRYSTAL STRUCTURE OF THE C-CBL TKB DOMAIN IN COMPLEX WITH THE APS PTYR-618 PHOSPHOPEPTIDE
Descriptor:CBL E3 ubiquitin protein ligase, 13-mer fragment of SH2 and PH domain-containing adapter protein APS, MAGNESIUM ION
Authors:Hu, J., Hubbard, S.R.
Deposit date:2005-02-15
Release date:2005-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Characterization of a Novel Cbl Phosphotyrosine Recognition Motif in the APS Family of Adapter Proteins
J.Biol.Chem., 280, 2005
2AUG
  • Download 2aug
  • View 2aug
Molmil generated image of 2aug
CRYSTAL STRUCTURE OF THE GRB14 SH2 DOMAIN
Descriptor:Growth factor receptor-bound protein 14
Authors:Depetris, R.S., Hu, J., Gimpelevich, I., Holt, L.J., Daly, R.J., Hubbard, S.R.
Deposit date:2005-08-27
Release date:2005-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for inhibition of the insulin receptor by the adaptor protein grb14.
Mol.Cell, 20, 2005
2AUH
  • Download 2auh
  • View 2auh
Molmil generated image of 2auh
CRYSTAL STRUCTURE OF THE GRB14 BPS REGION IN COMPLEX WITH THE INSULIN RECEPTOR TYROSINE KINASE
Descriptor:Insulin receptor, Growth factor receptor-bound protein 14, CALCIUM ION
Authors:Depetris, R.S., Hu, J., Gimpelevich, I., Holt, L.J., Daly, R.J., Hubbard, S.R.
Deposit date:2005-08-27
Release date:2005-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for inhibition of the insulin receptor by the adaptor protein grb14.
Mol.Cell, 20, 2005
2B4S
  • Download 2b4s
  • View 2b4s
Molmil generated image of 2b4s
CRYSTAL STRUCTURE OF A COMPLEX BETWEEN PTP1B AND THE INSULIN RECEPTOR TYROSINE KINASE
Descriptor:Tyrosine-protein phosphatase, non-receptor type 1, Insulin receptor, ...
Authors:Li, S., Depetris, R.S., Barford, D., Chernoff, J., Hubbard, S.R.
Deposit date:2005-09-26
Release date:2005-11-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of a Complex between Protein Tyrosine Phosphatase 1B and the Insulin Receptor Tyrosine Kinase.
Structure, 13, 2005
<12>
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2019 Protein Data Bank Japan