3ML4

Crystal structure of a complex between Dok7 PH-PTB and the MuSK juxtamembrane region

Summary for 3ML4

DescriptorProtein Dok-7, Muscle, skeletal receptor tyrosine-protein kinase (3 entities in total)
Functional Keywordstyrosine phosphorylation, adapter protein, dimerization, signaling protein
Biological sourceMus musculus (mouse)
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Cellular locationCell membrane; Peripheral membrane protein Q18PE0
Membrane; Single-pass type I membrane protein (Potential) Q61006
Total number of polymer chains8
Total molecular weight107416.77
Authors
Bergamin, E.,Hubbard, S.R. (deposition date: 2010-04-16, release date: 2010-07-14, Last modification date: 2011-07-13)
Primary citation
Bergamin, E.,Hallock, P.T.,Burden, S.J.,Hubbard, S.R.
The Cytoplasmic Adaptor Protein Dok7 Activates the Receptor Tyrosine Kinase MuSK via Dimerization.
Mol.Cell, 39:100-109, 2010
PubMed: 20603078 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2010.06.007
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers0.30280.7%6.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3ml4
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Molmil generated image of 3ml4
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Molmil generated image of 3ml4
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 3ml4
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Molmil generated image of 3ml4
rotated about x axis by 90°
Molmil generated image of 3ml4
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3ml4.pdb2.gz [69.46 KB])
Coordinate files for Biological unit (3ml4.pdb1.gz [69.1 KB])
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