2B4S

Crystal structure of a complex between PTP1B and the insulin receptor tyrosine kinase

Summary for 2B4S

Entry DOI	10.2210/pdb2b4s/pdb
Descriptor	Tyrosine-protein phosphatase, non-receptor type 1, Insulin receptor, SULFATE ION, ... (4 entities in total)
Functional Keywords	hydrolase/transferase, phosphorylation, tyrosine protein kinase, hydrolase-transferase complex
Biological source	Homo sapiens (human) More
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 Membrane; Single-pass type I membrane protein: P06213
Total number of polymer chains	4
Total formula weight	140404.96
Authors	Li, S.,Depetris, R.S.,Barford, D.,Chernoff, J.,Hubbard, S.R. (deposition date: 2005-09-26, release date: 2005-11-15, Last modification date: 2023-11-15)
Primary citation	Li, S.,Depetris, R.S.,Barford, D.,Chernoff, J.,Hubbard, S.R. Crystal Structure of a Complex between Protein Tyrosine Phosphatase 1B and the Insulin Receptor Tyrosine Kinase. Structure, 13:1643-1651, 2005 Cited by PubMed: 16271887 DOI: 10.1016/j.str.2005.07.019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation