2B4S

Crystal structure of a complex between PTP1B and the insulin receptor tyrosine kinase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Tyrosine-protein phosphatase, non-receptor type 1	polymer	298	34688.5	2	UniProt (P18031) Pfam (PF00102) In PDB	Homo sapiens (human)	Protein-tyrosine phosphatase 1B, PTP-1B
2	B, D	Insulin receptor	polymer	306	35033.7	2	UniProt (P06213) Pfam (PF07714) In PDB	Homo sapiens (human)	IR, CD220 antigen
3	A, B, C	SULFATE ION	non-polymer		96.1	10	Chemie (SO4)
4		water	water		18.0	377	Chemie (HOH)

Sequence modifications

A, C: 1 - 298 (UniProt: P18031)

PDB	External Database	Details
Ala 215	Cys 215	engineered mutation

B, D: 978 - 1283 (UniProt: P06213)

PDB	External Database	Details
Ser 981	Cys 1008	engineered mutation
Ptr 1158	Tyr 1185	modified residue
Ptr 1162	Tyr 1189	modified residue
Ptr 1163	Tyr 1190	modified residue
Asn 1251	Lys 1278	variant

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	139444.3
Non-Polymers*	Number of molecules	10
	Total formula weight	960.6
All*	Total formula weight	140405.0

*Water molecules are not included.