2B4S
Crystal structure of a complex between PTP1B and the insulin receptor tyrosine kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Tyrosine-protein phosphatase, non-receptor type 1 | polymer | 298 | 34688.5 | 2 | UniProt (P18031) Pfam (PF00102) | Homo sapiens (human) | Protein-tyrosine phosphatase 1B, PTP-1B |
| 2 | B, D (B, D) | Insulin receptor | polymer | 306 | 35033.7 | 2 | UniProt (P06213) Pfam (PF07714) | Homo sapiens (human) | IR, CD220 antigen |
| 3 | E, F, G, H, I... (A, B, C) | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 4 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 377 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 298 (UniProt: P18031)
B, D: 978 - 1283 (UniProt: P06213)
| PDB | External Database | Details |
|---|---|---|
| Ala 215 | Cys 215 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 981 | Cys 1008 | engineered mutation |
| Ptr 1158 | Tyr 1185 | modified residue |
| Ptr 1162 | Tyr 1189 | modified residue |
| Ptr 1163 | Tyr 1190 | modified residue |
| Asn 1251 | Lys 1278 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 139444.3 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 960.6 | |
| All* | Total formula weight | 140405.0 |
