6UFR
| Structure of recombinantly assembled E46K alpha-synuclein fibrils | Descriptor: | Alpha-synuclein | Authors: | Eisenberg, D.S, Boyer, D.R, Sawaya, M.R, Li, B, Jiang, L. | Deposit date: | 2019-09-24 | Release date: | 2020-02-19 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | The alpha-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure. Proc.Natl.Acad.Sci.USA, 117, 2020
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8DU2
| HnRNPA2 D290V LCD PM1 | Descriptor: | Heterogeneous nuclear ribonucleoproteins A2/B1 | Authors: | Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R. | Deposit date: | 2022-07-26 | Release date: | 2023-08-02 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation. J.Biol.Chem., 300, 2023
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8DUW
| HnRNPA2 D290V LCD PM2 | Descriptor: | Heterogeneous nuclear ribonucleoproteins A2/B1 | Authors: | Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R. | Deposit date: | 2022-07-27 | Release date: | 2023-08-02 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation. J.Biol.Chem., 300, 2023
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8EC7
| HnRNPA2 D290V LCD PM3 | Descriptor: | Heterogeneous nuclear ribonucleoproteins A2/B1 | Authors: | Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R. | Deposit date: | 2022-09-01 | Release date: | 2023-09-06 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation. J.Biol.Chem., 300, 2023
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6N4P
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6ODG
| SVQIVY, Crystal Structure of a tau protein fragment | Descriptor: | Microtubule-associated protein tau | Authors: | Eisenberg, D.S, Boyer, D.R, Sawaya, M.R, Seidler, P.M. | Deposit date: | 2019-03-26 | Release date: | 2019-10-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples. J.Biol.Chem., 294, 2019
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4UNT
| Induced monomer of the Mcg variable domain | Descriptor: | IG LAMBDA CHAIN V-II REGION MGC, SULFATE ION | Authors: | Brumshtein, B, Esswein, S.R, Landau, M, Ryan, C.M, Whitelegge, J.P, Phillips, M.L, Cascio, D, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2014-05-30 | Release date: | 2014-08-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Formation of Amyloid Fibers by Monomeric Light-Chain Variable Domains. J.Biol.Chem., 289, 2014
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5FOY
| De novo structure of the binary mosquito larvicide BinAB at pH 7 | Descriptor: | 41.9 KDA INSECTICIDAL TOXIN, LARVICIDAL TOXIN 51 KDA PROTEIN | Authors: | Colletier, J.P, Sawaya, M.R, Gingery, M, Rodriguez, J.A, Cascio, D, Brewster, A.S, Michels-Clark, T, Boutet, S, Williams, G.J, Messerschmidt, M, DePonte, D.P, Sierra, R.G, Laksmono, H, Koglin, J.E, Hunter, M.S, W Park, H, Uervirojnangkoorn, M, Bideshi, D.L, Brunger, A.T, Federici, B.A, Sauter, N.K, Eisenberg, D.S. | Deposit date: | 2015-11-26 | Release date: | 2016-10-05 | Last modified: | 2019-08-28 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | De Novo Phasing with X-Ray Laser Reveals Mosquito Larvicide Binab Structure. Nature, 539, 2016
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7SAS
| Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | Authors: | Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-09-23 | Release date: | 2022-03-09 | Last modified: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature, 605, 2022
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7SAQ
| Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | Authors: | Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-09-23 | Release date: | 2022-03-09 | Last modified: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature, 605, 2022
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7SAR
| Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | Authors: | Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-09-23 | Release date: | 2022-03-09 | Last modified: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature, 605, 2022
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4XFO
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4XFN
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6PES
| Cryo-EM structure of alpha-synuclein H50Q Wide Fibril | Descriptor: | Alpha-synuclein | Authors: | Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. | Deposit date: | 2019-06-20 | Release date: | 2019-11-27 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs. Nat.Struct.Mol.Biol., 26, 2019
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6PIL
| Antibody scFv-M204 monomeric state | Descriptor: | CHLORIDE ION, scFv-M204 antibody | Authors: | Abskharon, R, Sawaya, M.R, Seidler, P.M, Cascio, D, Eisenberg, D.S. | Deposit date: | 2019-06-26 | Release date: | 2020-06-24 | Last modified: | 2020-08-12 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. J.Biol.Chem., 295, 2020
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6VW2
| Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils | Descriptor: | Islet amyloid polypeptide (SUMO-tagged) | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2020-02-18 | Release date: | 2020-06-10 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils. Nat.Struct.Mol.Biol., 27, 2020
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6WPQ
| GNYNVF from hnRNPA2-low complexity domain segment, residues 286-291, D290V variant | Descriptor: | Heterogeneous nuclear ribonucleoprotein A2 | Authors: | Lu, J, Cao, Q, Hughes, M.P, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2020-04-27 | Release date: | 2020-08-19 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid. Nat Commun, 11, 2020
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7ROJ
| Amyloid-related segment of alphaB-crystallin residues 90-100 with G95W mutation | Descriptor: | Alpha-crystallin B chain peptide, GLYCEROL, SODIUM ION, ... | Authors: | Sawaya, M.R, Do, T.D, Eisenberg, D.S. | Deposit date: | 2021-07-30 | Release date: | 2022-01-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Atomic view of an amyloid dodecamer exhibiting selective cellular toxic vulnerability in acute brain slices. Protein Sci., 31, 2022
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7ROL
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6WQK
| hnRNPA2 Low complexity domain (LCD) determined by cryoEM | Descriptor: | MCherry fluorescent protein,Heterogeneous nuclear ribonucleoproteins A2/B1 chimera | Authors: | Lu, J, Cao, Q, Hughes, M.P, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2020-04-29 | Release date: | 2020-08-26 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid. Nat Commun, 11, 2020
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6AS9
| Filamentous Assembly of Green Fluorescent Protein Supported by a C-terminal fusion of 18-residues, viewed in space group P212121 form 2 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, Green fluorescent protein | Authors: | Sawaya, M.R, Heller, D.M, McPartland, L, Hochschild, A, Eisenberg, D.S. | Deposit date: | 2017-08-23 | Release date: | 2018-05-30 | Last modified: | 2019-11-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Atomic insights into the genesis of cellular filaments by globular proteins. Nat. Struct. Mol. Biol., 25, 2018
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6B79
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6BCS
| LilrB2 D1D2 domains complexed with benzamidine | Descriptor: | BENZAMIDINE, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | Authors: | Cao, Q, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2017-10-20 | Release date: | 2018-09-05 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Inhibiting amyloid-beta cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design. Nat Chem, 10, 2018
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4ZNN
| MicroED structure of the segment, GVVHGVTTVA, from the A53T familial mutant of Parkinson's disease protein, alpha-synuclein residues 47-56 | Descriptor: | Alpha-synuclein | Authors: | Rodriguez, J.A, Ivanova, M, Sawaya, M.R, Cascio, D, Reyes, F, Shi, D, Johnson, L, Guenther, E, Sangwan, S, Hattne, J, Nannenga, B, Brewster, A.S, Messerschmidt, M, Boutet, S, Sauter, N.K, Gonen, T, Eisenberg, D.S. | Deposit date: | 2015-05-05 | Release date: | 2015-09-09 | Last modified: | 2024-03-06 | Method: | ELECTRON CRYSTALLOGRAPHY (1.41 Å) | Cite: | Structure of the toxic core of alpha-synuclein from invisible crystals. Nature, 525, 2015
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5ACM
| Mcg immunoglobulin variable domain with methylene blue | Descriptor: | 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM, GLYCEROL, MCG, ... | Authors: | Brumshtein, B, Esswein, S.R, Salwinski, L, Phillips, M.L, Ly, A.T, Cascio, D, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2015-08-17 | Release date: | 2015-12-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. Elife, 4, 2015
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