Author results

1JBU
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COAGULATION FACTOR VII ZYMOGEN (EGF2/PROTEASE) IN COMPLEX WITH INHIBITORY EXOSITE PEPTIDE A-183
Descriptor:COAGULATION FACTOR VII, Peptide exosite inhibitor A-183, SULFATE ION, ...
Authors:Eigenbrot, C., Kirchhofer, D., Dennis, M.S., Santell, L., Lazarus, R.A., Stamos, J., Ultsch, M.H.
Deposit date:2001-06-06
Release date:2001-07-11
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:The factor VII zymogen structure reveals reregistration of beta strands during activation.
Structure, 9, 2001
1AAL
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STRUCTURAL EFFECTS INDUCED BY MUTAGENESIS AFFECTED BY CRYSTAL PACKING FACTORS: THE STRUCTURE OF A 30-51 DISULFIDE MUTANT OF BASIC PANCREATIC TRYPSIN INHIBITOR
Descriptor:BOVINE PANCREATIC TRYPSIN INHIBITOR, PHOSPHATE ION
Authors:Eigenbrot, C., Randal, M., Kossiakoff, A.A.
Deposit date:1992-04-09
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural effects induced by mutagenesis affected by crystal packing factors: the structure of a 30-51 disulfide mutant of basic pancreatic trypsin inhibitor.
Proteins, 14, 1992
3TJN
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HTRA1 CATALYTIC DOMAIN, APO FORM
Descriptor:Serine protease HTRA1
Authors:Eigenbrot, C., Ultsch, M.
Deposit date:2011-08-24
Release date:2012-05-16
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and Functional Analysis of HtrA1 and Its Subdomains.
Structure, 20, 2012
3TJO
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HTRA1 CATALYTIC DOMAIN, MUTATIONALLY INACTIVATED
Descriptor:Serine protease HTRA1, B-OCTYLGLUCOSIDE, SULFATE ION, ...
Authors:Eigenbrot, C., Ultsch, M.
Deposit date:2011-08-24
Release date:2012-05-16
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Structural and Functional Analysis of HtrA1 and Its Subdomains.
Structure, 20, 2012
3TJQ
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N-DOMAIN OF HTRA1
Descriptor:Serine protease HTRA1, PLATINUM (II) ION, CHLORIDE ION, ...
Authors:Eigenbrot, C., Ultsch, M.
Deposit date:2011-08-24
Release date:2012-05-16
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Structural and Functional Analysis of HtrA1 and Its Subdomains.
Structure, 20, 2012
6RLX
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X-RAY STRUCTURE OF HUMAN RELAXIN AT 1.5 ANGSTROMS. COMPARISON TO INSULIN AND IMPLICATIONS FOR RECEPTOR BINDING DETERMINANTS
Descriptor:RELAXIN, A-CHAIN, B-CHAIN
Authors:Eigenbrot, C., Randal, M., Kossiakoff, A.A.
Deposit date:1991-06-21
Release date:1993-10-31
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants.
J.Mol.Biol., 221, 1991
1FVC
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X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING
Descriptor:IGG1-KAPPA 4D5 FV (LIGHT CHAIN), IGG1-KAPPA 4D5 FV (HEAVY CHAIN)
Authors:Eigenbrot, C., Randal, M., Kossiakoff, A.A., Presta, L.
Deposit date:1992-10-20
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
J.Mol.Biol., 229, 1993
1FVD
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X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING
Descriptor:IGG1-KAPPA 4D5 FAB (LIGHT CHAIN), IGG1-KAPPA 4D5 FAB (HEAVY CHAIN)
Authors:Eigenbrot, C., Presta, L., Randal, M., Kossiakoff, A.A.
Deposit date:1992-10-20
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
J.Mol.Biol., 229, 1993
1FVE
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X-RAY STRUCTURES OF THE ANTIGEN-BINDING DOMAINS FROM THREE VARIANTS OF HUMANIZED ANTI-P185-HER2 ANTIBODY 4D5 AND COMPARISON WITH MOLECULAR MODELING
Descriptor:IGG1-KAPPA 4D5 FAB (LIGHT CHAIN), IGG1-KAPPA 4D5 FAB (HEAVY CHAIN)
Authors:Eigenbrot, C., Randal, M., Presta, L., Kossiakoff, A.A.
Deposit date:1992-10-20
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
J.Mol.Biol., 229, 1993
1AGQ
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GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT
Descriptor:GLIAL CELL-DERIVED NEUROTROPHIC FACTOR
Authors:Eigenbrot, C., Gerber, N.
Deposit date:1997-03-25
Release date:1997-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding.
Nat.Struct.Biol., 4, 1997
1FGV
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X-RAY STRUCTURES OF FRAGMENTS FROM BINDING AND NONBINDING VERSIONS OF A HUMANIZED ANTI-CD18 ANTIBODY: STRUCTURAL INDICATIONS OF THE KEY ROLE OF VH RESIDUES 59 TO 65
Descriptor:H52 FV (LIGHT CHAIN), H52 FV (HEAVY CHAIN)
Authors:Eigenbrot, C., Kessler, J.
Deposit date:1993-11-01
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray structures of fragments from binding and nonbinding versions of a humanized anti-CD18 antibody: structural indications of the key role of VH residues 59 to 65.
Proteins, 18, 1994
1ICW
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INTERLEUKIN-8, MUTANT WITH GLU 38 REPLACED BY CYS AND CYS 50 REPLACED BY ALA
Descriptor:INTERLEUKIN-8
Authors:Eigenbrot, C., Lowman, H.B., Chee, L., Artis, D.R.
Deposit date:1996-09-18
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structural change and receptor binding in a chemokine mutant with a rearranged disulfide: X-ray structure of E38C/C50AIL-8 at 2 A resolution.
Proteins, 27, 1997
1PG7
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MURINE 6A6 FAB IN COMPLEX WITH HUMANIZED ANTI-TISSUE FACTOR D3H44 FAB
Descriptor:humanized antibody D3H44, murine antibody 6A6 Fab fragment
Authors:Eigenbrot, C., Meng, Y.G., Krishnamurthy, R., Lipari, M.T., Presta, L., Devaux, B., Wong, T., Moran, P., Bullens, S., Kirchhofer, D.
Deposit date:2003-05-27
Release date:2003-08-26
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insight into how an anti-idiotypic antibody against D3H44 (anti-tissue factor antibody) restores normal coagulation.
J.Mol.Biol., 331, 2003
2FGW
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X-RAY STRUCTURES OF FRAGMENTS FROM BINDING AND NONBINDING VERSIONS OF A HUMANIZED ANTI-CD18 ANTIBODY: STRUCTURAL INDICATIONS OF THE KEY ROLE OF VH RESIDUES 59 TO 65
Descriptor:H52 FAB (LIGHT CHAIN), H52 FAB (HEAVY CHAIN)
Authors:Eigenbrot, C., Kessler, J.
Deposit date:1994-01-16
Release date:1994-04-30
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-ray structures of fragments from binding and nonbinding versions of a humanized anti-CD18 antibody: structural indications of the key role of VH residues 59 to 65.
Proteins, 18, 1994
3MZW
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HER2 EXTRACELLUAR REGION WITH AFFINITY MATURED 3-HELIX AFFIBODY ZHER2:342
Descriptor:Tyrosine kinase-type cell surface receptor HER2, Immunoglobulin G-binding protein A, N-ACETYL-D-GLUCOSAMINE
Authors:Eigenbrot, C., Ultsch, M.H.
Deposit date:2010-05-13
Release date:2010-07-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for high-affinity HER2 receptor binding by an engineered protein.
Proc.Natl.Acad.Sci.USA, 107, 2010
7PTI
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STRUCTURAL EFFECTS INDUCED BY REMOVAL OF A DISULFIDE BRIDGE. THE X-RAY STRUCTURE OF THE C30A(SLASH)C51A MUTANT OF BASIC PANCREATIC TRYPSIN INHIBITOR AT 1.6 ANGSTROMS
Descriptor:BOVINE PANCREATIC TRYPSIN INHIBITOR, PHOSPHATE ION
Authors:Eigenbrot, C., Randal, M., Kossiakoff, A.A.
Deposit date:1990-03-08
Release date:1991-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural effects induced by removal of a disulfide-bridge: the X-ray structure of the C30A/C51A mutant of basic pancreatic trypsin inhibitor at 1.6 A.
Protein Eng., 3, 1990
4IVA
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JAK2 KINASE (JH1 DOMAIN) IN COMPLEX WITH THE INHIBITOR TRANS-4-[(8AS)-2-[(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(8AH)-YL]CYCLOHEXANECARBONITRILE
Descriptor:Tyrosine-protein kinase JAK2, trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexanecarbonitrile
Authors:Eigenbrot, C., Shia, S.
Deposit date:2013-01-22
Release date:2013-05-22
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2.
J.Med.Chem., 56, 2013
4IVB
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JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH THE INHIBITOR TRANS-4-{2-[(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(6H)-YL}CYCLOHEXANECARBONITRILE
Descriptor:Tyrosine-protein kinase JAK1, trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexanecarbonitrile
Authors:Eigenbrot, C., Steffek, M.
Deposit date:2013-01-22
Release date:2013-05-22
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2.
J.Med.Chem., 56, 2013
4IVC
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JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH THE INHIBITOR (TRANS-4-{2-[(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(6H)-YL}CYCLOHEXYL)ACETONITRILE
Descriptor:Tyrosine-protein kinase JAK1, (trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexyl)acetonitrile
Authors:Eigenbrot, C., Shia, S.
Deposit date:2013-01-22
Release date:2013-05-22
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2.
J.Med.Chem., 56, 2013
4IVD
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JAK1 KINASE (JH1 DOMAIN) IN COMPLEX WITH COMPOUND 34
Descriptor:Tyrosine-protein kinase JAK1, 3-(trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexyl)propanenitrile
Authors:Eigenbrot, C., Steffek, M.
Deposit date:2013-01-22
Release date:2013-05-22
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2.
J.Med.Chem., 56, 2013
4RJ4
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EGFR KINASE (T790M/L858R) WITH INHIBITOR COMPOUND 6
Descriptor:Epidermal growth factor receptor, N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-1-(propan-2-yl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine
Authors:Eigenbrot, C., Yu, C.
Deposit date:2014-10-08
Release date:2014-11-26
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation.
J.Med.Chem., 57, 2014
4RJ5
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EGFR KINASE (T790M/L858R) WITH INHIBITOR COMPOUND 5
Descriptor:Epidermal growth factor receptor, N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine
Authors:Eigenbrot, C., Yu, C.
Deposit date:2014-10-08
Release date:2014-11-26
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation.
J.Med.Chem., 57, 2014
4RJ6
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EGFR KINASE (T790M/L858R) WITH INHIBITOR COMPOUND 4
Descriptor:Epidermal growth factor receptor, SULFATE ION, N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-2-(1H-pyrazol-4-yl)-3H-imidazo[4,5-c]pyridin-6-amine
Authors:Eigenbrot, C., Yu, C.
Deposit date:2014-10-08
Release date:2014-11-26
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation.
J.Med.Chem., 57, 2014
4RJ7
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EGFR KINASE (T790M/L858R) WITH INHIBITOR COMPOUND 1
Descriptor:Epidermal growth factor receptor, SULFATE ION, 2,6-dichloro-N-{2-[(2-{[(2S)-1-hydroxypropan-2-yl]amino}-6-methylpyrimidin-4-yl)amino]pyridin-4-yl}benzamide
Authors:Eigenbrot, C., Yu, C.
Deposit date:2014-10-08
Release date:2014-11-26
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation.
J.Med.Chem., 57, 2014
4RJ8
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EGFR KINASE (T790M/L858R) WITH INHIBITOR COMPOUND 8
Descriptor:Epidermal growth factor receptor, SULFATE ION, 1-cyclopentyl-N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-1H-pyrrolo[3,2-c]pyridin-6-amine
Authors:Eigenbrot, C., Yu, C.
Deposit date:2014-10-08
Release date:2014-11-26
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation.
J.Med.Chem., 57, 2014
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