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3EOX
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HIGH QUALITY STRUCTURE OF CLEAVED PAI-1-STAB
Descriptor:Plasminogen activator inhibitor 1
Authors:Dewilde, M., Declerck, P.J., Rabijns, A., Strelkov, S.V.
Deposit date:2008-09-29
Release date:2009-02-17
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:High quality structure of cleaved PAI-1-stab.
J.Struct.Biol., 165, 2009
3LW2
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MOUSE PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1)
Descriptor:Plasminogen activator inhibitor 1
Authors:Dewilde, M., Van De Craen, B., Compernolle, G., Madsen, J.B., Strelkov, S.V., Gils, A., Declerck, P.J.
Deposit date:2010-02-23
Release date:2010-04-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Subtle structural differences between human and mouse PAI-1 reveal the basis for biochemical differences.
J.Struct.Biol., 171, 2010
5HVF
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CRYSTAL STRUCTURE OF THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR IN COMPLEX WITH AN INHIBITORY NANOBODY (VHH-I83)
Descriptor:Carboxypeptidase B2, VHH-i83, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Zhou, X., Weeks, S.D., Strelkov, S.V., Declerck, P.J.
Deposit date:2016-01-28
Release date:2016-06-22
Last modified:2016-08-31
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.
J.Thromb.Haemost., 14, 2016
5HVG
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CRYSTAL STRUCTURE OF THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR IN COMPLEX WITH AN INHIBITORY NANOBODY (VHH-A204)
Descriptor:Carboxypeptidase B2, VHH-a204, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Zhou, X., Weeks, S.D., Strelkov, S.V., Declerck, P.J.
Deposit date:2016-01-28
Release date:2016-06-22
Last modified:2016-08-31
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.
J.Thromb.Haemost., 14, 2016
5HVH
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CRYSTAL STRUCTURE OF THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR IN COMPLEX WITH TWO INHIBITORY NANOBODIES
Descriptor:Carboxypeptidase B2, VHH-a204, VHH-i83, ...
Authors:Zhou, X., Weeks, S.D., Strelkov, S.V., Declerck, P.J.
Deposit date:2016-01-28
Release date:2016-06-22
Last modified:2016-08-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.
J.Thromb.Haemost., 14, 2016
5LHP
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THE P-AMINOBENZAMIDINE ACTIVE SITE INHIBITED CATALYTIC DOMAIN OF MURINE UROKINASE-TYPE PLASMINOGEN ACTIVATOR IN COMPLEX WITH THE ALLOSTERIC INHIBITORY NANOBODY NB7
Descriptor:Urokinase-type plasminogen activator, Camelid-Derived Antibody Fragment, SULFATE ION, ...
Authors:Kromann-Hansen, T., Lange, E.L., Sorensen, H.P., Ghassabeh, G.H., Huang, M., Jensen, J.K., Muyldermans, S., Declerck, P.J., Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHQ
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THE EGR-CMK ACTIVE SITE INHIBITED CATALYTIC DOMAIN OF MURINE UROKINASE-TYPE PLASMINOGEN ACTIVATOR IN COMPLEX WITH THE ALLOSTERIC INHIBITORY NANOBODY NB7
Descriptor:Urokinase-type plasminogen activator, Camelid-Derived Antibody Fragment Nb7, L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, ...
Authors:Kromann-Hansen, T., Lange, E.L., Sorensen, H.P., Ghassabeh, G.H., Huang, M., Jensen, J.K., Muyldermans, S., Declerck, P.J., Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHR
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THE CATALYTIC DOMAIN OF MURINE UROKINASE-TYPE PLASMINOGEN ACTIVATOR IN COMPLEX WITH THE ACTIVE SITE BINDING INHIBITORY NANOBODY NB22
Descriptor:Urokinase-type plasminogen activator, Camelid-Derived Antibody Fragment Nb22
Authors:Kromann-Hansen, T., Lange, E.L., Sorensen, H.P., Ghassabeh, G.H., Huang, M., Jensen, J.K., Muyldermans, S., Declerck, P.J., Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHS
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THE LIGAND FREE CATALYTIC DOMAIN OF MURINE UROKINASE-TYPE PLASMINOGEN ACTIVATOR
Descriptor:Urokinase-type plasminogen activator, SULFATE ION, NICKEL (II) ION
Authors:Kromann-Hansen, T., Lange, E.L., Sorensen, H.P., Ghassabeh, G.H., Huang, M., Jensen, J.K., Muyldermans, S., Declerck, P.J., Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Method:X-RAY DIFFRACTION (3.047 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
9PAI
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CLEAVED SUBSTRATE VARIANT OF PLASMINOGEN ACTIVATOR INHIBITOR-1
Descriptor:PROTEIN (PLASMINOGEN ACTIVATOR INHIBITOR-1) residues 19-364, PROTEIN (PLASMINOGEN ACTIVATOR INHIBITOR-1) residues 365-397
Authors:Aertgeerts, K., De Bondt, H.L., De Ranter, C.J., Declerck, P.J.
Deposit date:1999-03-11
Release date:1999-03-19
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1.
Nat.Struct.Biol., 2, 1995
1DB2
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CRYSTAL STRUCTURE OF NATIVE PLASMINOGEN ACTIVATOR INHIBITOR-1
Descriptor:PLASMINOGEN ACTIVATOR INHIBITOR-1
Authors:Nar, H., Bauer, M., Stassen, J.M., Lang, D., Gils, A., Declerck, P.
Deposit date:1999-11-02
Release date:1999-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation.
J.Mol.Biol., 297, 2000
5LHN
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THE CATALYTIC DOMAIN OF MURINE UROKINASE-TYPE PLASMINOGEN ACTIVATOR IN COMPLEX WITH THE ALLOSTERIC INHIBITORY NANOBODY NB7
Descriptor:Urokinase-type plasminogen activator, Camelid-Derived Antibody Fragment Nb7, SULFATE ION, ...
Authors:Kromann-Hansen, T., Lange, E.L., Sorensen, H.P., Ghassabeh, G.H., Huang, M., Jensen, J.K., Muyldermans, S., Declerck, P., Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5HDO
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CRYSTAL STRUCTURE OF A NANOBODY RAISED AGAINST UROKINASE-TYPE PLASMINOGEN ACTIVATOR
Descriptor:Anti-HCV NS3/4A serine protease immoglobulin heavy chain, SULFATE ION, CHLORIDE ION
Authors:Kromann-Hansen, T.
Deposit date:2016-01-05
Release date:2016-06-01
Last modified:2016-07-27
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior.
J.Biol.Chem., 291, 2016
5HGG
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CRYSTAL STRUCTURE OF UPA IN COMPLEX WITH A CAMELID-DERIVED ANTIBODY FRAGMENT
Descriptor:Urokinase-type plasminogen activator, Camelid Derived Antibody Fragment, Nb4, ...
Authors:Yung, K.W.Y., Kromann-Hansen, T., Andreasen, P.A., Ngo, J.C.K.
Deposit date:2016-01-08
Release date:2016-06-01
Last modified:2016-08-10
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior
J.Biol.Chem., 291, 2016