5HGG
Crystal structure of uPA in complex with a camelid-derived antibody fragment
Summary for 5HGG
Entry DOI | 10.2210/pdb5hgg/pdb |
Descriptor | Urokinase-type plasminogen activator, Camelid Derived Antibody Fragment, Nb4, GLYCEROL, ... (7 entities in total) |
Functional Keywords | upa, nanobody, serine protease, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P00749 |
Total number of polymer chains | 4 |
Total formula weight | 84538.65 |
Authors | Yung, K.W.Y.,Kromann-Hansen, T.,Andreasen, P.A.,Ngo, J.C.K. (deposition date: 2016-01-08, release date: 2016-06-01, Last modification date: 2016-08-10) |
Primary citation | Kromann-Hansen, T.,Oldenburg, E.,Yung, K.W.,Ghassabeh, G.H.,Muyldermans, S.,Declerck, P.J.,Huang, M.,Andreasen, P.A.,Ngo, J.C. A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior J.Biol.Chem., 291:15156-15168, 2016 Cited by PubMed: 27226628DOI: 10.1074/jbc.M116.732503 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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