5HGG
Crystal structure of uPA in complex with a camelid-derived antibody fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Urokinase-type plasminogen activator | polymer | 246 | 27715.6 | 2 | UniProt (P00749) Pfam (PF00089) | Homo sapiens (Human) | uPA |
| 2 | C, D (S, T) | Camelid Derived Antibody Fragment, Nb4 | polymer | 128 | 13598.0 | 2 | Vicugna pacos | ||
| 3 | E, F, G, N, O (A, B, T) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 4 | H, K (B, S) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | I, J, M (S, T) | (3S)-3-[(2S,3S,4R)-3,4-DIMETHYLTETRAHYDROFURAN-2-YL]BUTYL LAURATE | non-polymer | 354.6 | 3 | Chemie (TWN) | |||
| 6 | L (S) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 7 | P, Q, R, S (A, B, S, T) | water | water | 18.0 | 287 | Chemie (HOH) |
Sequence modifications
A, B: 16 - 243 (UniProt: P00749)
| PDB | External Database | Details |
|---|---|---|
| Ala 122 | Cys 299 | engineered mutation |
| Gln 145 | Asn 322 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 82627.1 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1911.5 | |
| All* | Total formula weight | 84538.7 |
