5HGG

Crystal structure of uPA in complex with a camelid-derived antibody fragment

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue GOL A 301

Chain	Residue
A	HIS170
A	LYS223
A	ASP223
S	GLY10
S	LEU11
S	GLN122
S	THR124

---

site_id	AC2
Number of Residues	5
Details	binding site for residue GOL A 302

Chain	Residue
A	ASP223
A	HOH404
T	GLN13
A	HIS170
A	LYS223

---

site_id	AC3
Number of Residues	5
Details	binding site for residue GOL B 301

Chain	Residue
B	HIS170
B	TYR171
B	ASP223
B	HOH424
T	GOL202

---

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 B 302

Chain	Residue
B	SER125
B	MET126
B	ARG239

---

site_id	AC5
Number of Residues	9
Details	binding site for residue TWN S 201

Chain	Residue
B	THR147
S	ARG45
S	TYR95
S	TRP117
S	TWN202
T	ARG45
T	TRP117
T	TWN201
T	HOH341

---

site_id	AC6
Number of Residues	9
Details	binding site for residue TWN S 202

Chain	Residue
A	TYR149
B	TYR149
S	ARG45
S	HIS100
S	LEU103
S	GLU115
S	TRP117
S	TWN201
T	GLU44

---

site_id	AC7
Number of Residues	5
Details	binding site for residue SO4 S 203

Chain	Residue
S	SER52
S	SER54
S	GLY56
S	SER57
S	HOH328

---

site_id	AC8
Number of Residues	7
Details	binding site for residue MES S 204

Chain	Residue
A	MET126
A	ARG239
A	HOH403
S	LEU11
S	GLN13
S	SER127
S	HOH317

---

site_id	AC9
Number of Residues	10
Details	binding site for residue TWN T 201

Chain	Residue
A	TYR149
S	GLU44
S	TWN201
T	PHE37
T	ARG45
T	LEU103
T	GLU115
T	TRP117
T	HOH314
T	HOH340

---

site_id	AD1
Number of Residues	9
Details	binding site for residue GOL T 202

Chain	Residue
B	HIS170
B	LYS223
B	ASP223
B	LYS224
B	GOL301
T	GLY10
T	LEU11
T	GLN122
T	THR124

---

site_id	AD2
Number of Residues	4
Details	binding site for residue GOL T 203

Chain	Residue
T	SER7
T	GLY8
T	GLY9
T	THR121

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ISATHC

Chain	Residue	Details
A	ILE53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV

Chain	Residue	Details
A	ASP189-VAL200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	490
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"9151681","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000026"}

Chain

Residue

Details

---