5HVF

Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory Nanobody (VHH-i83)

Summary for 5HVF

• Entry DOI: 10.2210/pdb5hvf/pdb
• Related: 5HVG 5HVH
• Descriptor: Carboxypeptidase B2, VHH-i83, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: procarboxypeptidase u, thrombin-activatable fibrinolysis inhibitor, tafi, procarboxypeptidase r, plasma procarboxypeptidase b, nanobody, antibody fragment, protein complex, hydrolase/hydrolase inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 60624.13

Authors

Zhou, X.,Weeks, S.D.,Strelkov, S.V.,Declerck, P.J. (deposition date: 2016-01-28, release date: 2016-06-22, Last modification date: 2024-01-10)

• Primary citation: Zhou, X.,Weeks, S.D.,Ameloot, P.,Callewaert, N.,Strelkov, S.V.,Declerck, P.J.; Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.; J.Thromb.Haemost., 14:1629-1638, 2016; PubMed: 27279497; DOI: 10.1111/jth.13381

Experimental method

X-RAY DIFFRACTION (2.85 Å)