5HVF
Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory Nanobody (VHH-i83)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Carboxypeptidase B2 | polymer | 401 | 46080.2 | 1 | UniProt (Q96IY4) Pfam (PF02244) Pfam (PF00246) | Homo sapiens (Human) | Carboxypeptidase U,CPU,Plasma carboxypeptidase B,pCPB,Thrombin-activable fibrinolysis inhibitor,TAFI |
| 2 | B (B) | VHH-i83 | polymer | 119 | 12877.1 | 1 | Vicugna pacos (Alpaca) | ||
| 3 | C (C) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 4 | D, E, F (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 5 | G (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | H (A) | CITRATE ANION | non-polymer | 189.1 | 1 | Chemie (FLC) | |||
| 7 | I, J (A, B) | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
A: 1 - 401 (UniProt: Q96IY4)
| PDB | External Database | Details |
|---|---|---|
| Cys 305 | Ser 327 | engineered mutation |
| Ile 329 | Thr 351 | engineered mutation |
| Tyr 333 | His 355 | engineered mutation |
| Gln 335 | His 357 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58957.3 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 748.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 918.1 | |
| All* | Total formula weight | 60624.1 |
