5HVF
Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory Nanobody (VHH-i83)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Carboxypeptidase B2 | polymer | 401 | 46080.2 | 1 | UniProt (Q96IY4) Pfam (PF02244) Pfam (PF00246) In PDB | Homo sapiens (Human) | Carboxypeptidase U,CPU,Plasma carboxypeptidase B,pCPB,Thrombin-activable fibrinolysis inhibitor,TAFI |
2 | B | VHH-i83 | polymer | 119 | 12877.1 | 1 | Vicugna pacos (Alpaca) | ||
3 | C | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
4 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
5 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
6 | A | CITRATE ANION | non-polymer | 189.1 | 1 | Chemie (FLC) | |||
7 | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
A: 1 - 401 (UniProt: Q96IY4)
PDB | External Database | Details |
---|---|---|
Cys 305 | Ser 327 | engineered mutation |
Ile 329 | Thr 351 | engineered mutation |
Tyr 333 | His 355 | engineered mutation |
Gln 335 | His 357 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 58957.3 | |
Branched | Number of molecules | 1 |
Total formula weight | 748.7 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 918.1 | |
All* | Total formula weight | 60624.1 |