Author results

5UQY
  • Download 5uqy
  • View 5uqy
Molmil generated image of 5uqy
CRYSTAL STRUCTURE OF MARBURG VIRUS GP IN COMPLEX WITH THE HUMAN SURVIVOR ANTIBODY MR78
Descriptor:ENVELOPE GLYCOPROTEIN GP1, ENVELOPE GLYCOPROTEIN GP2, MR78 Fab light chain, ...
Authors:Hashiguchi, T., Fusco, M.L., Hastie, K.M., Bomholdt, Z.A., Lee, J.E., Flyak, A.I., Matsuoka, R., Kohda, D., Yanagi, Y., Hammel, M., Crowe, J.E., Saphire, E.O.
Deposit date:2017-02-08
Release date:2017-03-01
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for Marburg virus neutralization by a cross-reactive human antibody.
Cell, 160, 2015
4HFW
  • Download 4hfw
  • View 4hfw
Molmil generated image of 4hfw
ANTI ROTAVIRUS ANTIBODY
Descriptor:6-26 Fab Light chain, 6-26 Fab Heavy chain, SULFATE ION
Authors:Spiller, B.W., Aiyegbo, M., Crowe, J.E.
Deposit date:2012-10-05
Release date:2013-05-29
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Human Rotavirus VP6-Specific Antibodies Mediate Intracellular Neutralization by Binding to a Quaternary Structure in the Transcriptional Pore.
Plos One, 8, 2013
4UIH
  • Download 4uih
  • View 4uih
Molmil generated image of 4uih
CRYO-EM STRUCTURE OF DENGUE VIRUS SEROTYPE 2 STRAIN NEW GUINEA-C COMPLEXED WITH HUMAN ANTIBODY 2D22 FAB AT 37 DEGREE C. THE FAB MOLECULES WERE ADDED TO THE VIRUS BEFORE 37 DEGREE C INCUBATION.
Descriptor:DENGUE VIRUS SEROTYPE 2 STRAIN NEW GUINEA-C E PROTEIN ECTODOMAIN, ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 -HEAVY CHAIN, ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 -LIGHT CHAIN
Authors:Fibriansah, G., Ibarra, K.D., Ng, T.-S., Smith, S.A., Tan, J.L., Lim, X.N., Ooi, J.S.G., Kostyuchenko, V.A., Wang, J., de Silva, A.M., Harris, E., Crowe, J.E., Lok, S.-M.
Deposit date:2015-03-30
Release date:2015-07-15
Last modified:2018-02-07
Method:ELECTRON MICROSCOPY (20 Å)
Cite:Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers.
Science, 349, 2015
5CGY
  • Download 5cgy
  • View 5cgy
Molmil generated image of 5cgy
FAB FRAGMENT OF CHIKUNGUNYA VIRUS NEUTRALIZING HUMAN MONOCLONAL ANTIBODY 4J21
Descriptor:Heavy Chain of Fab, Light Chain of Fab
Authors:Long, F., Crowe, J.E., Rossmann, M.G.
Deposit date:2015-07-09
Release date:2015-11-11
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity.
Proc.Natl.Acad.Sci.USA, 112, 2015
5CHN
  • Download 5chn
  • View 5chn
Molmil generated image of 5chn
FAB FRAGMENTS OF CHIKUNGUNYA VIRUS NEUTRALIZING HUMAN MONOCLONAL ANTIBODY 5M16
Descriptor:Antibody 5M16 Fab Heavy Chain, Antibody 5M16 Fab Light Chain
Authors:Long, F., Crowe, J.E., Rossmann, M.G.
Deposit date:2015-07-10
Release date:2015-11-11
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.047 Å)
Cite:Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity.
Proc.Natl.Acad.Sci.USA, 112, 2015
5ITB
  • Download 5itb
  • View 5itb
Molmil generated image of 5itb
CRYSTAL STRUCTURE OF THE ANTI-RSV F FAB 14N4
Descriptor:anti-RSV F Fab 14N4 Heavy chain, anti-RSV F Fab 14N4 Light chain
Authors:Mousa, J.J., Crowe, J.E.
Deposit date:2016-03-16
Release date:2016-10-26
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein.
Proc.Natl.Acad.Sci.USA, 113, 2016
5J3D
  • Download 5j3d
  • View 5j3d
Molmil generated image of 5j3d
CRYSTAL STRUCTURE OF HUMAN FAB 14N4 IN COMPLEX WITH POST-FUSION RSV F
Descriptor:14N4 heavy chain, 14N4 light chain, Fusion glycoprotein F0
Authors:Mousa, J.J., Crowe, J.E.
Deposit date:2016-03-30
Release date:2016-10-26
Last modified:2016-11-23
Method:X-RAY DIFFRACTION (4.077 Å)
Cite:Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein.
Proc.Natl.Acad.Sci.USA, 113, 2016
5TPN
  • Download 5tpn
  • View 5tpn
Molmil generated image of 5tpn
CRYSTAL STRUCTURE OF RSV F IN COMPLEX WITH HUMAN ANTIBODY HRSV90
Descriptor:Fusion glycoprotein F0,Fibritin, hRSV90 heavy chain, hRSV0 light chain
Authors:Mousa, J.J., Crowe, J.E.
Deposit date:2016-10-20
Release date:2017-02-01
Method:X-RAY DIFFRACTION (3.141 Å)
Cite:Crystal structure of RSV F in complex with human antibody hRSV90
To Be Published
5WEQ
  • Download 5weq
  • View 5weq
Molmil generated image of 5weq
THE CRYSTAL STRUCTURE OF A MR78 MUTANT
Descriptor:MR78 mutant light chain, MR78 mutant Fab heavy chain
Authors:Dong, J., Williamson, L.E., Crowe, J.E.
Deposit date:2017-07-10
Release date:2018-04-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein.
Structure, 25, 2017
6CHX
  • Download 6chx
  • View 6chx
Molmil generated image of 6chx
HIGH RESOLUTION CRYSTAL STRUCTURE OF THE HEMAGGLUTININ H1 HEAD DOMAIN OF INFLUENZA A VIRUS SOLOMON ISLANDS
Descriptor:Hemagglutinin
Authors:Dong, J., Sevy, A.M., Crowe, J.E.
Deposit date:2018-02-23
Release date:2019-02-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:High Resolution Crystal Structure of the Hemagglutinin H1 Head Domain of Influenza A virus Solomon Islands
To Be Published
6DL8
  • Download 6dl8
  • View 6dl8
Molmil generated image of 6dl8
CRYSTAL STRUCTURE OF AN INFLUENZA A HEMAGGLUTININ ANTIBODY FAB VARIANT CH67:1203D4 CHIMERA
Descriptor:CH67:1203d4 FAB light chain, Ch67:1203d4 FAB heavy chain
Authors:Dong, J., Finn, J.A., Crowe, J.E.
Deposit date:2018-05-31
Release date:2019-06-05
Method:X-RAY DIFFRACTION (3.805 Å)
Cite:Crystal Structure of an influenza A hemagglutinin antibody Fab variant CH67:1203d4 chimera
To Be Published
6DLA
  • Download 6dla
  • View 6dla
Molmil generated image of 6dla
CRYSTAL STRUCTURES OF AN INFLUENZA A HEMAGGLUTININ ANTIBODY FAB CH65:7969D2
Descriptor:CH65:7969d2 Fab heavy chain, CH65:7969d2 Fab light chain, SULFATE ION
Authors:Dong, J., Crowe, J.E., Finn, J.A.
Deposit date:2018-05-31
Release date:2019-06-05
Method:X-RAY DIFFRACTION (2.004 Å)
Cite:Crystal structures of an influenza A hemagglutinin antibody Fab CH65:7969d2
To Be Published
6DLB
  • Download 6dlb
  • View 6dlb
Molmil generated image of 6dlb
CRYSTAL STRUCTURE OF AN INFLUENZA A HEMAGGLUTININ ANTIBODY FAB CH65:1203D4 CHIMERA
Descriptor:CH65:1203d4 Fab heavy chain, CH65:1203d4 Fab light chain, SULFATE ION
Authors:Dong, J., Finn, J.A., Crowe, J.E.
Deposit date:2018-05-31
Release date:2019-06-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of an influenza A hemagglutinin antibody Fab CH65:1203d4 chimera
To Be Published
3J6S
  • Download 3j6s
  • View 3j6s
Molmil generated image of 3j6s
CRYO-EM STRUCTURE OF DENGUE VIRUS SEROTYPE 3 AT 28 DEGREES C
Descriptor:envelope protein, membrane protein
Authors:Fibriansah, G., Tan, J.L., Smith, S.A., de Alwis, R., Ng, T.-S., Kostyuchenko, V.A., Kukkaro, P., de Silva, A.M., Crowe Jr., J.E., Lok, S.-M.
Deposit date:2014-03-24
Release date:2015-03-04
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (6 Å)
Cite:A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins.
Nat Commun, 6, 2015
3J6T
  • Download 3j6t
  • View 3j6t
Molmil generated image of 3j6t
CRYO-EM STRUCTURE OF DENGUE VIRUS SEROTYPE 3 AT 37 DEGREES C
Descriptor:envelope protein, membrane protein
Authors:Fibriansah, G., Tan, J.L., Smith, S.A., de Alwis, R., Ng, T.-S., Kostyuchenko, V.A., Kukkaro, P., de Silva, A.M., Crowe Jr., J.E., Lok, S.-M.
Deposit date:2014-03-25
Release date:2015-03-04
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (7 Å)
Cite:A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins.
Nat Commun, 6, 2015
3J6U
  • Download 3j6u
  • View 3j6u
Molmil generated image of 3j6u
CRYO-EM STRUCTURE OF DENGUE VIRUS SEROTYPE 3 IN COMPLEX WITH HUMAN ANTIBODY 5J7 FAB
Descriptor:envelope protein, membrane protein, Fab 5J7 heavy chain, ...
Authors:Fibriansah, G., Tan, J.L., Smith, S.A., de Alwis, R., Ng, T.-S., Kostyuchenko, V.A., Kukkaro, P., de Silva, A.M., Crowe Jr., J.E., Lok, S.-M.
Deposit date:2014-03-26
Release date:2015-03-04
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (9 Å)
Cite:A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins.
Nat Commun, 6, 2015
4UIF
  • Download 4uif
  • View 4uif
Molmil generated image of 4uif
CRYO-EM STRUCTURE OF DENGUE VIRUS SEROTYPE 2 IN COMPLEX WITH ANTIGEN-BINDING FRAGMENTS OF HUMAN ANTIBODY 2D22
Descriptor:DENGUE VIRUS SEROTYPE 2 STRAIN PVP94 07 - ENVELOPE PROTEIN, DENGUE VIRUS SEROTYPE 2 STRAIN STRAIN PVP94 07 - MEMBRANE PROTEIN, ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 - HEAVY CHAIN, ...
Authors:Fibriansah, G., Ibarra, K.D., Ng, T.-S., Smith, S.A., Tan, J.L., Lim, X.-N., Ooi, J.S.G., Kostyuchenko, V.A., Wang, J., de Silva, A.M., Harris, E., Crowe Junior, J.E., Lok, S.-M.
Deposit date:2015-03-30
Release date:2015-07-15
Last modified:2018-02-07
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers.
Science, 349, 2015
5A1Z
  • Download 5a1z
  • View 5a1z
Molmil generated image of 5a1z
CRYO-EM STRUCTURE OF DENGUE VIRUS SEROTYPE 2 STRAIN PVP94-07 COMPLEXED WITH HUMAN ANTIBODY 2D22 FAB AT 37 DEGREES C
Descriptor:ENVELOPE PROTEIN, MEMBRANE GLYCOPROTEIN, ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 - HEAVY CHAIN, ...
Authors:Fibriansah, G., Ibarra, K.D., Ng, T.S., Smith, S.A., Tan, J.L., Lim, X.N., Ooi, J.S.G., Kostyuchenko, V.A., Wang, J., de Silva, A.M., Harris, E., Crowe Jr, J.E., Lok, S.M.
Deposit date:2015-05-06
Release date:2015-07-15
Last modified:2018-02-07
Method:ELECTRON MICROSCOPY (6.9 Å)
Cite:Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers.
Science, 349, 2015
5KEL
  • Download 5kel
  • View 5kel
Molmil generated image of 5kel
EBOV GP IN COMPLEX WITH VARIABLE FAB DOMAINS OF IGGS C2G4 AND C13C6
Descriptor:Ebola surface glycoprotein, GP1, GP2, ...
Authors:Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B.
Deposit date:2016-06-09
Release date:2016-09-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
Nat Microbiol, 1, 2016
5KEM
  • Download 5kem
  • View 5kem
Molmil generated image of 5kem
EBOV SGP IN COMPLEX WITH VARIABLE FAB DOMAINS OF IGGS C13C6 AND BDBV91
Descriptor:BDBV91 variable Fab domain light chain, BDBV91 variable Fab domain heavy chain, c13C6 variable Fab domain heavy chain, ...
Authors:Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B.
Deposit date:2016-06-09
Release date:2016-09-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
Nat Microbiol, 1, 2016
5KEN
  • Download 5ken
  • View 5ken
Molmil generated image of 5ken
EBOV GP IN COMPLEX WITH VARIABLE FAB DOMAINS OF IGGS C4G7 AND C13C6
Descriptor:Ebola surface glycoprotein, GP1, GP2, ...
Authors:Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B.
Deposit date:2016-06-09
Release date:2016-09-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
Nat Microbiol, 1, 2016
5UHY
  • Download 5uhy
  • View 5uhy
Molmil generated image of 5uhy
A HUMAN ANTIBODY AGAINST ZIKA VIRUS CROSSLINKS THE E PROTEIN TO PREVENT INFECTION
Descriptor:ZV67 Fab chain 1, ZV67 Fab chain 2, envelope protein
Authors:Hasan, S.S., Miller, A., Sapparapu, G., Fernandez, E., Klose, T., Long, F., Fokine, A., Porta, J.C., Jiang, W., Diamond, M.S., Crowe Jr., J.E., Kuhn, R.J., Rossmann, M.G.
Deposit date:2017-01-12
Release date:2017-03-29
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:A human antibody against Zika virus crosslinks the E protein to prevent infection.
Nat Commun, 8, 2017
6E8V
  • Download 6e8v
  • View 6e8v
Molmil generated image of 6e8v
THE CRYSTAL STRUCTURE OF BOVINE ULTRALONG ANTIBODY BOV-1
Descriptor:Bovine ultralong antibody BOV-1 Heavy chain, Bovine ultralong antibody BOV-1 light chain
Authors:Dong, J., Crowe, J.E.
Deposit date:2018-07-31
Release date:2019-09-04
Method:X-RAY DIFFRACTION (3.79 Å)
Cite:Structural Diversity of Ultralong CDRH3s in Seven Bovine Antibody Heavy Chains.
Front Immunol, 10, 2019
6E9G
  • Download 6e9g
  • View 6e9g
Molmil generated image of 6e9g
THE CRYSTAL STRUCTURE OF BOVINE ULTRALONG ANTIBODY BOV-2
Descriptor:Bovine ultralong antibody BOV-2 heavy chain, Bovine ultralong antibody BOV-2 light chain
Authors:Dong, J., Crowe, J.E.
Deposit date:2018-08-01
Release date:2019-05-01
Method:X-RAY DIFFRACTION (2.904 Å)
Cite:Structural Diversity of Ultralong CDRH3s in Seven Bovine Antibody Heavy Chains.
Front Immunol, 10, 2019
6E9H
  • Download 6e9h
  • View 6e9h
Molmil generated image of 6e9h
THE CRYSTAL STRUCTURE OF BOVINE ULTRALONG ANTIBODY BOV-3
Descriptor:Bovine ultralong antibody BOV-3 heavy chain, Bovine ultralong antibody BOV-3 light chain
Authors:Dong, J., Crowe, J.E.
Deposit date:2018-08-01
Release date:2019-05-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Diversity of Ultralong CDRH3s in Seven Bovine Antibody Heavy Chains.
Front Immunol, 10, 2019
<123>