Author results

6U48
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E. COLI 50S WITH PHAZOLICIN (PHZ) BOUND IN EXIT TUNNEL
Descriptor:23S rRNA, 5S rRNA, 50S ribosomal protein uL2, ...
Authors:Watson, Z.L., Cate, J.H.D., Polikanov, Y.S., Severinov, K.
Deposit date:2019-08-23
Release date:2019-09-18
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (2.87 Å)
Cite:Phazolicin - a Novel Thiazole/Oxazole-Modified Peptide Inhibiting the Bacterial Ribosome in a Species-Specific Way
To be Published
6OM7
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HUMAN RIBOSOME NASCENT CHAIN COMPLEX (PCSK9-RNC) STALLED BY A DRUG-LIKE SMALL MOLECULE WITH AA AND PE TRNAS
Descriptor:18S ribosomal RNA, 40S ribosomal protein SA, 40S ribosomal protein S3a, ...
Authors:Li, W., Cate, J.H.D.
Deposit date:2019-04-18
Release date:2019-06-19
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OM0
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HUMAN RIBOSOME NASCENT CHAIN COMPLEX (PCSK9-RNC) STALLED BY A DRUG-LIKE MOLECULE WITH AP AND PE TRNAS
Descriptor:18S ribosomal RNA, 40S ribosomal protein SA, 40S ribosomal protein S3a, ...
Authors:Li, W., Cate, J.H.D.
Deposit date:2019-04-17
Release date:2019-06-19
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OLZ
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HUMAN RIBOSOME NASCENT CHAIN COMPLEX (PCSK9-RNC) STALLED BY A DRUG-LIKE MOLECULE WITH PP TRNA
Descriptor:60S ribosomal protein L8, 40S ribosomal protein SA, 60S ribosomal protein L3, ...
Authors:Li, W., Cate, J.H.D.
Deposit date:2019-04-17
Release date:2019-06-19
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OLI
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STRUCTURE OF HUMAN RIBOSOME NASCENT CHAIN COMPLEX SELECTIVELY STALLED BY A DRUG-LIKE SMALL MOLECULE (USO1-RNC)
Descriptor:18S ribosomal RNA, 40S ribosomal protein SA, 40S ribosomal protein S3a, ...
Authors:Li, W., Cate, J.H.D.
Deposit date:2019-04-16
Release date:2019-06-19
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OLG
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HUMAN RIBOSOME NASCENT CHAIN COMPLEX STALLED BY A DRUG-LIKE SMALL MOLECULE (CDH1_RNC WITH PP TRNA)
Descriptor:60S ribosomal protein L8, 40S ribosomal protein SA, 60S ribosomal protein L3, ...
Authors:Li, W., Cate, J.H.D.
Deposit date:2019-04-16
Release date:2019-06-19
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OLF
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HUMAN RIBOSOME NASCENT CHAIN COMPLEX (CDH1-RNC) STALLED BY A DRUG-LIKE MOLECULE WITH AA AND PE TRNAS
Descriptor:18S ribosomal RNA, 40S ribosomal protein SA, 40S ribosomal protein S3a, ...
Authors:Li, W., Cate, J.H.D.
Deposit date:2019-04-16
Release date:2019-06-19
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OLE
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HUMAN RIBOSOME NASCENT CHAIN COMPLEX (CDH1-RNC) STALLED BY A DRUG-LIKE MOLECULE WITH AP AND PE TRNAS
Descriptor:18S ribosomal RNA, 40S ribosomal protein SA, 40S ribosomal protein S3a, ...
Authors:Li, W., Cate, J.H.D.
Deposit date:2019-04-16
Release date:2019-06-19
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6I7V
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RIBOSOMAL PROTEIN PARALOGS BL31 AND BL36
Descriptor:16S ribosmal RNA, 16S ribosomal RNA, 23S ribosomal RNA, ...
Authors:Pulk, A., Cate, J.H.D., Remme, J., Lilleorg, S., Reier, K., Peil, L., Liiv, A., Tammsalu, T.
Deposit date:2018-11-19
Release date:2018-12-05
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Bacterial ribosome heterogeneity: Changes in ribosomal protein composition during transition into stationary growth phase.
Biochimie, 156, 2018
5K4D
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STRUCTURE OF EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D (EIF3D) CAP BINDING DOMAIN FROM NASONIA VITRIPENNIS, CRYSTAL FORM 3
Descriptor:Eukaryotic translation initiation factor 3 subunit D
Authors:Kranzusch, P.J., Lee, A.S.Y., Doudna, J.A., Cate, J.H.D.
Deposit date:2016-05-20
Release date:2016-07-27
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.
Nature, 536, 2016
5K4C
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STRUCTURE OF EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D (EIF3D) CAP BINDING DOMAIN FROM NASONIA VITRIPENNIS, CRYSTAL FORM 2
Descriptor:Eukaryotic translation initiation factor 3 subunit D, GLYCEROL
Authors:Kranzusch, P.J., Lee, A.S.Y., Doudna, J.A., Cate, J.H.D.
Deposit date:2016-05-20
Release date:2016-07-27
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.
Nature, 536, 2016
5K4B
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STRUCTURE OF EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D (EIF3D) CAP BINDING DOMAIN FROM NASONIA VITRIPENNIS, CRYSTAL FORM 1
Descriptor:Eukaryotic translation initiation factor 3 subunit D, CHLORIDE ION
Authors:Kranzusch, P.J., Lee, A.S.Y., Doudna, J.A., Cate, J.H.D.
Deposit date:2016-05-20
Release date:2016-07-27
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.399 Å)
Cite:eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.
Nature, 536, 2016
4YBB
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HIGH-RESOLUTION STRUCTURE OF THE ESCHERICHIA COLI RIBOSOME
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Noeske, J., Wasserman, M.R., Terry, D.S., Altman, R.B., Blanchard, S.C., Cate, J.H.D.
Deposit date:2015-02-18
Release date:2015-03-18
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High-resolution structure of the Escherichia coli ribosome.
Nat.Struct.Mol.Biol., 22, 2015
4WWW
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CRYSTAL STRUCTURE OF THE E. COLI RIBOSOME BOUND TO CEM-101
Descriptor:23S rRNA, 5S rRNA, 50S ribosomal protein L2, ...
Authors:Dunkle, J.A., Zhang, W., Cate, J.H.D., Mankin, A.S.
Deposit date:2014-11-12
Release date:2014-12-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis.
Antimicrob. Agents Chemother., 54, 2010
4WOI
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4,5-LINKED AMINOGLYCOSIDE ANTIBIOTICS REGULATE THE BACTERIAL RIBOSOME BY TARGETING DYNAMIC CONFORMATIONAL PROCESSES WITHIN INTERSUBUNIT BRIDGE B2
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Pulk, A., Cate, J.H.D., Blanchard, S., Wasserman, M., Altman, R., Zhou, Z., Zinder, J., Green, K., Garneau-Tsodikova, S.
Deposit date:2014-10-15
Release date:2015-08-05
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions.
Nat Commun, 6, 2015
4WF1
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CRYSTAL STRUCTURE OF THE E. COLI RIBOSOME BOUND TO NEGAMYCIN.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Olivier, N.B., Altman, R.B., Noeske, J., Basarab, G.S., Code, E., Ferguson, A.D., Gao, N., Huang, J., Juette, M.F., Livchak, S., Miller, M.D., Prince, D.B., Cate, J.H.D., Buurman, E.T., Blanchard, S.C.
Deposit date:2014-09-11
Release date:2014-11-05
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.
Proc.Natl.Acad.Sci.USA, 111, 2014
4V9P
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CONTROL OF RIBOSOMAL SUBUNIT ROTATION BY ELONGATION FACTOR G
Descriptor:23S rRNA, 5S rRNA, 50S ribosomal protein L2, ...
Authors:Pulk, A., Cate, J.H.D.
Deposit date:2013-05-03
Release date:2014-07-09
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Control of ribosomal subunit rotation by elongation factor G.
Science, 340, 2013
4V9O
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CONTROL OF RIBOSOMAL SUBUNIT ROTATION BY ELONGATION FACTOR G
Descriptor:5S rRNA, 50S ribosomal protein L2, 23S rRNA, ...
Authors:Pulk, A., Cate, J.H.D.
Deposit date:2013-05-03
Release date:2014-07-09
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Control of ribosomal subunit rotation by elongation factor G.
Science, 340, 2013
4V9D
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STRUCTURES OF THE BACTERIAL RIBOSOME IN CLASSICAL AND HYBRID STATES OF TRNA BINDING
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Dunkle, J.A., Wang, L., Feldman, M.B., Pulk, A., Chen, V.B., Kapral, G.J., Noeske, J., Richardson, J.S., Blanchard, S.C., Cate, J.H.D.
Deposit date:2012-07-31
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of the bacterial ribosome in classical and hybrid states of tRNA binding.
Science, 332, 2011
4V9C
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ALLOSTERIC CONTROL OF THE RIBOSOME BY SMALL-MOLECULE ANTIBIOTICS
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Cate, J.H.D., Pulk, A., Blanchard, S.C., Wang, L., Feldman, M.B., Wasserman, M.R., Altman, R.
Deposit date:2012-07-25
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Allosteric control of the ribosome by small-molecule antibiotics.
Nat.Struct.Mol.Biol., 19, 2012
4V7V
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CRYSTAL STRUCTURE OF THE E. COLI RIBOSOME BOUND TO CLINDAMYCIN.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Dunkle, J.A., Xiong, L., Mankin, A.S., Cate, J.H.D.
Deposit date:2010-08-16
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.2891 Å)
Cite:Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V7U
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CRYSTAL STRUCTURE OF THE E. COLI RIBOSOME BOUND TO ERYTHROMYCIN.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Dunkle, J.A., Xiong, L., Mankin, A.S., Cate, J.H.D.
Deposit date:2010-08-15
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V7T
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CRYSTAL STRUCTURE OF THE E. COLI RIBOSOME BOUND TO CHLORAMPHENICOL.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Dunkle, J.A., Xiong, L., Mankin, A.S., Cate, J.H.D.
Deposit date:2010-08-14
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.1942 Å)
Cite:Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V7S
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CRYSTAL STRUCTURE OF THE E. COLI RIBOSOME BOUND TO TELITHROMYCIN.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Dunkle, J.A., Xiong, L., Mankin, A.S., Cate, J.H.D.
Deposit date:2010-08-05
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.2547 Å)
Cite:Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V6E
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CRYSTAL STRUCTURE OF THE E. COLI 70S RIBOSOME IN AN INTERMEDIATE STATE OF RATCHETING
Descriptor:30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Zhang, W., Dunkle, J.A., Cate, J.H.D.
Deposit date:2009-06-28
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.712 Å)
Cite:Structures of the ribosome in intermediate States of ratcheting.
Science, 325, 2009
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