Author results

5IBM
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STRUCTURE OF S502P, A CANCER-ASSOCIATED MUTATION OF THE ONCOGENIC PHOSPHATASE SHP2
Descriptor:Tyrosine-protein phosphatase non-receptor type 11
Authors:Blacklow, S.C., Stams, T., Fodor, M., LaRochelle, J.R.
Deposit date:2016-02-22
Release date:2016-04-13
Last modified:2016-05-04
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.
Biochemistry, 55, 2016
5IBS
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STRUCTURE OF E76Q, A CANCER-ASSOCIATED MUTATION OF THE ONCOGENIC PHOSPHATASE SHP2
Descriptor:Tyrosine-protein phosphatase non-receptor type 11
Authors:Blacklow, S.C., Stams, T., Fodor, M., LaRochelle, J.R.
Deposit date:2016-02-22
Release date:2016-04-13
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.
Biochemistry, 55, 2016
6BN5
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NON-RECEPTOR PROTEIN TYROSINE PHOSPHATASE SHP2 F285S IN COMPLEX WITH ALLOSTERIC INHIBITOR JLR-2
Descriptor:Tyrosine-protein phosphatase non-receptor type 11, 3-benzyl-8-chloro-2-hydroxy-4H-pyrimido[2,1-b][1,3]benzothiazol-4-one
Authors:Blacklow, S.C., Stams, T., Fodor, M., LaRochelle, J.R.
Deposit date:2017-11-16
Release date:2017-12-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.
Bioorg. Med. Chem., 25, 2017
1D2J
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LDL RECEPTOR LIGAND-BINDING MODULE 6
Descriptor:LOW-DENSITY LIPOPROTEIN RECEPTOR, CALCIUM ION
Authors:North, C.L., Blacklow, S.C.
Deposit date:1999-09-23
Release date:2000-03-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the sixth LDL-A module of the LDL receptor.
Biochemistry, 39, 2000
1AJJ
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LDL RECEPTOR LIGAND-BINDING MODULE 5, CALCIUM-COORDINATING
Descriptor:LOW-DENSITY LIPOPROTEIN RECEPTOR, SULFATE ION, CALCIUM ION
Authors:Fass, D., Blacklow, S.C., Kim, P.S., Berger, J.M.
Deposit date:1997-05-04
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module.
Nature, 388, 1997
1IJQ
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CRYSTAL STRUCTURE OF THE LDL RECEPTOR YWTD-EGF DOMAIN PAIR
Descriptor:LOW-DENSITY LIPOPROTEIN RECEPTOR
Authors:Jeon, H., Meng, W., Takagi, J., Eck, M.J., Springer, T.A., Blacklow, S.C.
Deposit date:2001-04-27
Release date:2001-05-23
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair.
Nat.Struct.Biol., 8, 2001
1L3Y
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INTEGRIN EGF-LIKE MODULE 3 FROM THE BETA-2 SUBUNIT
Descriptor:Integrin beta-2:CYSTEINE-RICH MODULE 3
Authors:Beglova, N., Blacklow, S.C., Takagi, J., Springer, T.A.
Deposit date:2002-03-03
Release date:2002-04-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation.
Nat.Struct.Biol., 9, 2002
1NTV
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CRYSTAL STRUCTURE OF THE DISABLED-1 (DAB1) PTB DOMAIN-APOER2 PEPTIDE COMPLEX
Descriptor:Disabled homolog 1, Apolipoprotein E Receptor-2 peptide, PHOSPHATE ION
Authors:Stolt, P.C., Jeon, H., Song, H.K., Herz, J., Eck, M.J., Blacklow, S.C.
Deposit date:2003-01-30
Release date:2003-04-15
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Origins of Peptide Selectivity and Phosphoinositide Binding Revealed by Structures of Disabled-1 PTB Domain Complexes
Structure, 11, 2003
1NU2
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CRYSTAL STRUCTURE OF THE MURINE DISABLED-1 (DAB1) PTB DOMAIN-APOER2 PEPTIDE-PI-4,5P2 TERNARY COMPLEX
Descriptor:Disabled homolog 1, peptide derived from murine Apolipoprotein E Receptor-2, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE
Authors:Stolt, P.C., Jeon, H., Song, H.K., Herz, J., Eck, M.J., Blacklow, S.C.
Deposit date:2003-01-30
Release date:2003-04-15
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Origins of Peptide Selectivity and Phosphoinositide Binding Revealed by Structures of Disabled-1 PTB Domain Complexes
Structure, 11, 2003
1PB5
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NMR STRUCTURE OF A PROTOTYPE LNR MODULE FROM HUMAN NOTCH1
Descriptor:Neurogenic locus notch homolog protein 1, CALCIUM ION
Authors:Vardar, D., North, C.L., Sanchez-Irizarry, C., Aster, J.C., Blacklow, S.C.
Deposit date:2003-05-14
Release date:2003-06-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Nuclear Magnetic Resonance Structure of a Prototype Lin12-Notch Repeat Module from Human Notch1
Biochemistry, 42, 2003
1Q68
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SOLUTION STRUCTURE OF T-CELL SURFACE GLYCOPROTEIN CD4 AND PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK FRAGMENTS
Descriptor:T-cell surface glycoprotein CD4, Proto-oncogene tyrosine-protein kinase LCK, ZINC ION
Authors:Kim, P.W., Sun, Z.Y., Blacklow, S.C., Wagner, G., Eck, M.J.
Deposit date:2003-08-12
Release date:2003-11-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.
Science, 301, 2003
1Q69
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SOLUTION STRUCTURE OF T-CELL SURFACE GLYCOPROTEIN CD8 ALPHA CHAIN AND PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK FRAGMENTS
Descriptor:T-cell surface glycoprotein CD8 alpha chain, Proto-oncogene tyrosine-protein kinase LCK, ZINC ION
Authors:Kim, P.W., Sun, Z.Y., Blacklow, S.C., Wagner, G., Eck, M.J.
Deposit date:2003-08-12
Release date:2003-11-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.
Science, 301, 2003
1XFE
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SOLUTION STRUCTURE OF THE LA7-EGFA PAIR FROM THE LDL RECEPTOR
Descriptor:Low-density lipoprotein receptor, CALCIUM ION
Authors:Beglova, N., Jeon, H., Fisher, C., Blacklow, S.C.
Deposit date:2004-09-14
Release date:2004-11-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Cooperation between Fixed and Low pH-Inducible Interfaces Controls Lipoprotein Release by the LDL Receptor
Mol.Cell, 16, 2004
2F8X
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CRYSTAL STRUCTURE OF ACTIVATED NOTCH, CSL AND MAML ON HES-1 PROMOTER DNA SEQUENCE
Descriptor:5'-D(*GP*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*AP*AP*A)-3', 5'-D(*TP*TP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*TP*AP*AP*C)-3', Recombining binding protein suppressor of hairless, ...
Authors:Nam, Y., Sliz, P., Blacklow, S.C.
Deposit date:2005-12-04
Release date:2006-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
Cell(Cambridge,Mass.), 124, 2006
2F8Y
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CRYSTAL STRUCTURE OF HUMAN NOTCH1 ANKYRIN REPEATS TO 1.55A RESOLUTION.
Descriptor:Notch homolog 1, translocation-associated (Drosophila), SULFATE ION
Authors:Nam, Y., Sliz, P., Blacklow, S.C.
Deposit date:2005-12-04
Release date:2006-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
Cell(Cambridge,Mass.), 124, 2006
2FCW
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STRUCTURE OF A COMPLEX BETWEEN THE PAIR OF THE LDL RECEPTOR LIGAND-BINDING MODULES 3-4 AND THE RECEPTOR ASSOCIATED PROTEIN (RAP).
Descriptor:Alpha-2-macroglobulin receptor-associated protein, Low-density lipoprotein receptor, SODIUM ION, ...
Authors:Beglova, N., Fisher, C., Blacklow, S.C.
Deposit date:2005-12-12
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Structure of an LDLR-RAP Complex Reveals a General Mode for Ligand Recognition by Lipoprotein Receptors
Mol.Cell, 22, 2006
2OO4
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STRUCTURE OF LNR-HD (NEGATIVE REGULATORY REGION) FROM HUMAN NOTCH 2
Descriptor:Neurogenic locus notch homolog protein 2, CALCIUM ION, ZINC ION, ...
Authors:Gordon, W.R., Vardar-Ulu, D., Histen, G., Sanchez-Irizarry, C., Aster, J.C., Blacklow, S.C.
Deposit date:2007-01-25
Release date:2007-04-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:Structural basis for autoinhibition of Notch
Nat.Struct.Mol.Biol., 14, 2007
3ETO
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2 ANGSTROM XRAY STRUCTURE OF THE NOTCH1 NEGATIVE REGULATORY REGION (NRR)
Descriptor:Neurogenic locus notch homolog protein 1, CALCIUM ION, CHLORIDE ION, ...
Authors:Gordon, W.R., Blacklow, S.C.
Deposit date:2008-10-08
Release date:2008-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL.
Blood, 113, 2009
3I08
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CRYSTAL STRUCTURE OF THE S1-CLEAVED NOTCH1 NEGATIVE REGULATORY REGION (NRR)
Descriptor:Neurogenic locus notch homolog protein 1, CALCIUM ION, CHLORIDE ION
Authors:Gordon, W.R., Blacklow, S.C.
Deposit date:2009-06-24
Release date:2009-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.
Plos One, 4, 2009
3NBN
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CRYSTAL STRUCTURE OF A DIMER OF NOTCH TRANSCRIPTION COMPLEX TRIMERS ON HES1 DNA
Descriptor:Recombining binding protein suppressor of hairless, Neurogenic locus notch homolog protein 1, Mastermind-like protein 1, ...
Authors:Arnett, K.L., Blacklow, S.C.
Deposit date:2010-06-03
Release date:2010-11-03
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes.
Nat.Struct.Mol.Biol., 17, 2010
4TSE
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CRYSTAL STRUCTURE OF THE MIB REPEAT DOMAIN OF MIND BOMB 1
Descriptor:E3 ubiquitin-protein ligase MIB1
Authors:McMillan, B.J., Blacklow, S.C.
Deposit date:2014-06-18
Release date:2015-03-18
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.057 Å)
Cite:A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases.
Mol.Cell, 57, 2015
4XI6
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CRYSTAL STRUCTURE OF THE MZM-REP DOMAINS OF MIND BOMB 1
Descriptor:E3 ubiquitin-protein ligase MIB1, ZINC ION, SULFATE ION
Authors:McMillan, B.J., Blacklow, S.C.
Deposit date:2015-01-06
Release date:2015-03-18
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases.
Mol.Cell, 57, 2015
4XI7
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CRYSTAL STRUCTURE OF THE MZM-REP DOMAINS OF MIND BOMB 1 IN COMPLEX WITH JAGGED1 N-BOX PEPTIDE
Descriptor:E3 ubiquitin-protein ligase MIB1, Jagged 1 N-box peptide, ZINC ION, ...
Authors:McMillan, B.J., Blacklow, S.C.
Deposit date:2015-01-06
Release date:2015-03-18
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.051 Å)
Cite:A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases.
Mol.Cell, 57, 2015
4XIB
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CRYSTAL STRUCTURE OF THE MZM-REP DOMAINS OF MIND BOMB 1 IN COMPLEX WITH FLY DELTA N-BOX PEPTIDE
Descriptor:E3 ubiquitin-protein ligase MIB1, Delta N-box peptide, ZINC ION, ...
Authors:McMillan, B.J., Blacklow, S.C.
Deposit date:2015-01-06
Release date:2015-03-18
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.147 Å)
Cite:A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases.
Mol.Cell, 57, 2015
4ZLP
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CRYSTAL STRUCTURE OF NOTCH3 NEGATIVE REGULATORY REGION
Descriptor:Neurogenic locus notch homolog protein 3, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xu, X., Blacklow, S.C.
Deposit date:2015-05-01
Release date:2015-08-19
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.479 Å)
Cite:Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region.
Structure, 23, 2015
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