Crystal structure of the human FOXN3 DNA binding domain in complex with a forkhead-like (FHL) DNA sequence

Summary for 6NCM

DescriptorForkhead box protein N3, DNA (5'-D(*AP*TP*AP*GP*CP*GP*TP*CP*TP*TP*AP*GP*CP*AP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*TP*GP*CP*TP*AP*AP*GP*AP*CP*GP*CP*TP*A)-3'), ... (5 entities in total)
Functional Keywordssequence specific dna binding, regulation of transcription dna templated, dna binding transcription factor activity, forkhead, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total molecular weight33199
Rogers, J.M.,Jarrett, S.M.,Seegar, T.C.,Waters, C.T.,Hallworth, A.N.,Blacklow, S.C.,Bulyk, M.L. (deposition date: 2018-12-11, release date: 2019-02-27, Last modification date: 2019-05-01)
Primary citation
Rogers, J.M.,Waters, C.T.,Seegar, T.C.M.,Jarrett, S.M.,Hallworth, A.N.,Blacklow, S.C.,Bulyk, M.L.
Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes.
Mol. Cell, 74:245-, 2019
PubMed: 30826165 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2019.01.019
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.27620 0.6% 3.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6ncm
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Molmil generated image of 6ncm
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Molmil generated image of 6ncm
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