6NCM

Crystal structure of the human FOXN3 DNA binding domain in complex with a forkhead-like (FHL) DNA sequence

Summary for 6NCM

• Entry DOI: 10.2210/pdb6ncm/pdb
• Related: 6NCE
• Descriptor: Forkhead box protein N3, DNA (5'-D(*AP*TP*AP*GP*CP*GP*TP*CP*TP*TP*AP*GP*CP*AP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*TP*GP*CP*TP*AP*AP*GP*AP*CP*GP*CP*TP*A)-3'), ... (5 entities in total)
• Functional Keywords: sequence specific dna binding, regulation of transcription dna templated, dna binding transcription factor activity, forkhead, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 33199.00

Authors

Rogers, J.M.,Jarrett, S.M.,Seegar, T.C.,Waters, C.T.,Hallworth, A.N.,Blacklow, S.C.,Bulyk, M.L. (deposition date: 2018-12-11, release date: 2019-02-27, Last modification date: 2023-10-11)

• Primary citation: Rogers, J.M.,Waters, C.T.,Seegar, T.C.M.,Jarrett, S.M.,Hallworth, A.N.,Blacklow, S.C.,Bulyk, M.L.; Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes.; Mol. Cell, 74:245-, 2019; PubMed: 30826165; DOI: 10.1016/j.molcel.2019.01.019

Experimental method

X-RAY DIFFRACTION (2.704 Å)