8ESV
Structure of human ADAM10-Tspan15 complex bound to 11G2 vFab
Summary for 8ESV
Entry DOI | 10.2210/pdb8esv/pdb |
EMDB information | 28580 |
Descriptor | Disintegrin and metalloproteinase domain-containing protein 10, 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE, CHOLESTEROL HEMISUCCINATE, ... (11 entities in total) |
Functional Keywords | protease, metalloprotease, tetraspanin, sheddase, adhesion, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 146651.73 |
Authors | Lipper, C.H.,Blacklow, S.C. (deposition date: 2022-10-14, release date: 2023-06-14, Last modification date: 2023-08-30) |
Primary citation | Lipper, C.H.,Egan, E.D.,Gabriel, K.H.,Blacklow, S.C. Structural basis for membrane-proximal proteolysis of substrates by ADAM10. Cell, 186:3632-3641.e10, 2023 Cited by PubMed: 37516108DOI: 10.1016/j.cell.2023.06.026 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
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