8ESV
Structure of human ADAM10-Tspan15 complex bound to 11G2 vFab
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Disintegrin and metalloproteinase domain-containing protein 10 | polymer | 543 | 60477.3 | 1 | UniProt (O14672) Pfam (PF13574) Pfam (PF00200) Pfam (PF21299) In PDB | Homo sapiens (human) | ADAM 10,CDw156,Kuzbanian protein homolog,Mammalian disintegrin-metalloprotease |
2 | B | Tetraspanin-15 | polymer | 306 | 34740.5 | 1 | UniProt (O95858) Pfam (PF00335) In PDB | Homo sapiens (human) | Tspan-15,Tetraspan NET-7,Transmembrane 4 superfamily member 15 |
3 | H | 11G2 Fab Heavy Chain | polymer | 225 | 24135.1 | 1 | Mus musculus (house mouse) | ||
4 | L | 11G2 Fab Light Chain | polymer | 221 | 24185.8 | 1 | Mus musculus (house mouse) | ||
5 | C | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G48068RF) | |||
6 | D | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62182OO) | |||
7 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
8 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
9 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
10 | A | 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE | non-polymer | 477.6 | 1 | Chemie (BAT) | |||
11 | B | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 2 | Chemie (Y01) |
Sequence modifications
A: 214 - 748 (UniProt: O14672)
B: 1 - 294 (UniProt: O95858)
PDB | External Database | Details |
---|---|---|
Asp 206 | - | expression tag |
Tyr 207 | - | expression tag |
Lys 208 | - | expression tag |
Asp 209 | - | expression tag |
Asp 210 | - | expression tag |
Asp 211 | - | expression tag |
Asp 212 | - | expression tag |
Lys 213 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -11 | - | initiating methionine |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Lys 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 143538.7 | |
Branched | Number of molecules | 2 |
Total formula weight | 1335.2 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1777.8 | |
All* | Total formula weight | 146651.7 |